Results 101 to 110 of about 774,918 (251)

Exploring the relationship between cue-induced craving and withdrawal craving in MUD individuals based on a virtual-reality cue exposure paradigm

BMC Psychiatry
Background This study developed a virtual reality (VR) drug cue exposure paradigm for individuals with methamphetamine use disorder (MUD) to investigate the characteristics of withdrawal craving and cue-induced craving and their relationship.
Qiuping Huang, Xinxin Chen, Ying Tang, Xuhao Wang, Wenwu Wang, Li Chao, Yiqi Nie, Shihua Peng, Lin Zhao, Hongxian Shen, Zhenjiang Liao   +10 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Shock isolation systems incorporating Coulomb friction

, 2012
This study investigates a novel approach to the problem of shock isolation. The questions considered are whether friction produces a better performance in terms of reduced response during a shock compared to viscous damping and a lower residual response ...
Ismail, Mohd
core   +1 more source

HIVGenoPipe: a nextflow pipeline for the detection of HIV-1 drug resistance using a real-time sample-specific reference sequence

BMC Bioinformatics
Background The emergence of HIV drug resistance is a challenge in controlling the acquired immunodeficiency syndrome (AIDS) pandemic caused by human immunodeficiency virus-1 (HIV-1) infection.
Thoai Dotrang, Brad T. Sherman, Lisheng Dai, Muhammad Ayub Khan, Helene C. Highbarger, Whitney Bruchey, Sylvain Laverdure, Michael W. Baseler, Tomozumi Imamichi, Robin L. Dewar, Weizhong Chang   +10 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Virtual reality-based cue exposure therapy reduces psychological craving in men with methamphetamine use disorder: a randomized controlled trial

Translational Psychiatry
Reducing psychological craving is critical for preventing relapse in methamphetamine use disorder (MUD). This study aimed to evaluate the efficacy of virtual reality (VR)-based cue exposure therapy (CET) and cue exposure with aversion therapy (CETA) in ...
Qiuping Huang, Xinxin Chen, Xuhao Wang, Ying Tang, Wenwu Wang, Li Chao, Yiqi Nie, Shihua Peng, Lin Zhao, Hongxian Shen, Zhenjiang Liao   +10 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Comparative effects of Health Qigong and closed motor exercise on the physical and mental health of female drug rehabilitation participants: a randomized controlled trial

BMC Complementary Medicine and Therapies
Background Drug rehabilitation is a challenging process that impacts both the physical and mental health of individuals. Traditional martial arts, such as Health Qigong, and closed motor exercises, such as power cycling, have shown potential benefits in ...
Guang Yang, Deyu Meng, Shichun He, Meiqi Wei, Man Li, Lu Zhang, Zhendong Pan, Ziheng Wang   +7 more
doaj   +1 more source