Journal of the agricultural chemical society of Japan, 1962 不飽和カルボン酸に対するグリニヤール試薬の1, 4付加反応をイソロイシンの合成に応用し,新合成法を確立した.すなわち,クロトン酸およびそのsec-ブチルエステルにエチルマグネシウムブロミドを作用せしめた後,その反応コンプレックスにハロゲンを付加し,得られたα-ハロゲンカルボン酸をアミノ化してイソロイシンを合成した.なお,この際グリニヤールコンプレックスへのヨウ素付加においてスレオ型が優先して生ずることより,その付加が隣接基の立体効果をうける現象を認めた.
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Acetylation‐Deacetylation‐Driven Natural Product Biosynthesis
ChemistryEurope, EarlyView.This review summarizes the role of acetylation‐deacetylation in natural product biosynthesis, including acetylation followed by deacetylation after several biosynthetic steps, acetylation‐mediated rearrangement, acetylation‐triggered elimination, and the acetylation cycle as a regulatory mechanism. These processes are vital for the formation of complex
Huibin Wang, Ikuro Abe
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Electromigration dispersion in Capillary Electrophoresis
, 2011 In a previous paper (S. Ghosal and Z. Chen Bull. Math. Biol. 2010, vol. 72, pg. 2047) it was shown that the evolution of the solute concentration in capillary electrophoresis is described by a nonlinear wave equation that reduced to Burger's equation if ...
Chen, Zhen, Ghosal, Sandip
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ChemistryEurope, EarlyView.A standalone enzyme, derived from the reductase domain of a polyketide synthase‐nonribosomal peptide synthetase hybrid enzyme, is identified as a pyrroline carboxylate reductase. This enzyme is involved in the biosynthesis of 3‐methylproline, an amino acid building block of a unique tricyclic pyrrolizidinone structure of a fungal metabolite ...
Naoki Kato +6 more
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THREONINE, ISOLEUCINE, AND ISOLEUCINE-VALINE MUTANTS OF SALMONELLA TYPHIMURIUM [PDF]
Genetics, 1960 Milislav Demerec, E. V. Glanville
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Identification of a New Interesting BAG3 Modulator Able to Disrupt Cancer‐Related Pathways
ChemMedChem, Accepted Article.Continuing our research aimed at discovering new BAG3 modulators as attractive anticancer drug candidates, we performed a screening campaign on an in‐house library, including compounds featuring a large variety of scaffolds. The obtained results induced us to focus on the triazole moiety and, following a stepwise structural refinement of the scaffold ...
Dafne Ruggiero +10 more
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Vibrational Partition Functions from Bond Order and Populations Relationships
ChemPhysChem, EarlyView.A new computational model is presented that predicts vibrational partition functions using bond orders and populations relationships (QBOP). This model demonstrates that thermochemical energy contributions can be reasonably approximated based on well‐conditioned orbital populations without the need for a costly Hessian calculation.
Barbaro Zulueta, John A. Keith
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Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study. [PDF]
, 2015 Aims/hypothesis: South Asian individuals have an increased risk of diabetes compared with Europeans that is unexplained by obesity and traditional or established metabolic measures.
Ala-Korpela, M +10 more
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Advances in Isotope Labeling for Solution Nucleic Acid Nuclear Magnetic Resonance Spectroscopy
ChemPlusChem, EarlyView.Recent advances in the field of nucleic acid nuclear magnetic resonance (NMR) are presented. Stable isotope labeling protocols and new approaches to segmentally label nucleic acid with NMR‐active residues are summarized. The novel methods will have a strong impact on the future of nucleic acid NMR and the characterization of structure and dynamics of ...
Stefan Hilber +3 more
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Incorporation spécifique de la L‐[U‐14C] isoleucine dans le groupement hydroxy‐2 méthyl‐2 butyroyle de la glaucarubinone [PDF]
, 1968 Jacqueline Moron, Judith Polonsky
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