Results 231 to 240 of about 183,864 (337)

Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells. [PDF]

Cancer Metab
Nishikubo K, Ohgaki R, Okanishi H, Xu M, Kanai Y.   +4 more
europepmc   +1 more source

Amino Acid Imbalance Is an Independent Factor for Mortality in Patients With Liver Cirrhosis

Alimentary Pharmacology &Therapeutics, EarlyView.
Amino acid imbalance, reflected by a low branched‐chain amino acids (BCAA)‐to‐tyrosine ratio (BTR), independently predicts mortality in patients with cirrhosis. Both decreased serum BCAA and increased tyrosine levels are significant and independent prognostic markers.
Yuki Utakata, Takao Miwa, Shinji Unome, Naoya Masuda, Mikita Oi, Masashi Aiba, Kenji Imai, Koji Takai, Makoto Shiraki, Naoki Katsumura, Masahito Shimizu   +10 more
wiley   +1 more source

Additional Valine and Isoleucine Impact Growth Performance, Intestinal Health, and Muscle Growth in Broilers Under Necrotic Enteritis Challenges. [PDF]

Animals (Basel)
Goo D, Kim WK.
europepmc   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Impact of High-Fat Diet and Aflatoxin B1 on Immunometabolic Dysfunction and the Dose-Responsive Modulation by Isoleucine Supplementation. [PDF]

Nutrients
Wang R, Wang J, Lan M, Wang X.
europepmc   +1 more source

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

LAT1/SLC7A5‐mediated amino acid uptake is regulated by redox signals triggered by formyl‐peptide receptor 2

The FEBS Journal, EarlyView.
FPR2 activation mediates NOX‐dependent LAT1 expression and, in turn, promotes mTORC1 signaling. Upon stimulation with WKYMVm, the FPR2‐NOX2‐ROS axis upregulates LAT1 via increased c‐Myc phosphorylation and decreased miR‐126. Additionally, it promotes CD98 translocation to the plasma membrane.
Myrhiam Cassese, Chiara Brignola, Stefano Marrone, Gabriella Esposito, Rosario Ammendola, Fabio Cattaneo   +5 more
wiley   +1 more source

Effect of High-Temperature Stress on Fatty Acid Composition and Undecylprodiginine Biosynthesis in <i>Streptomyces coelicolor</i> M511. [PDF]

Microorganisms
Han Y, Park Y, Han K, Mo S.
europepmc   +1 more source

Excitatory actions of peptide histidine isoleucine on thalamic relay neurons

, 2008
Sang‐Hun Lee, Charles L. Cox
openalex   +2 more sources

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source