Results 281 to 290 of about 197,005 (375)

Senescence Cell Induction Methods Display Diverse Metabolic Reprogramming and Reveal an Underpinning Serine/Taurine Reductive Metabolic Phenotype

Aging Cell, EarlyView.
This study reveals that in vitro senescence induction methods significantly influence intracellular biomolecular profiles, showing both shared and unique metabolic responses. A novel bioanalytical pipeline was developed to explore these subphenotypes, highlighting the importance of targeting metabolic redox circuits and serine/taurine pathways for ...
Domenica Berardi, Gillian Farrell, Abdullah AlSultan, Ashley McCulloch, Nicole M. Hall, Rui Pedro Pereira Sousa, Melanie Jimenez, Colin Selman, Ilaria Bellantuono, Caroline H. Johnson, Zahra Rattray, Nicholas J. W. Rattray   +11 more
wiley   +1 more source

Dietary lipids are largely deposited in skin and rapidly affect insulating properties. [PDF]

Nat Commun
Riley N, Kasza I, Hermsmeyer IDK, Trautman ME, Barrett-Wilt G, Jain R, Simcox JA, Yen CE, MacDougald OA, Lamming DW, Alexander CM.   +10 more
europepmc   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

Amino Acids From Root Exudates Induce Bacillus Spore Germination to Enhance Root Colonisation and Plant Growth Promotion. [PDF]

Microb Biotechnol
Tao L, Sun X, Beauregard PB, Tan T, Zhang Y, Xie J, Huang G, Zhang N, Miao Y, Shen Q, Xu Z, Zhang R.   +11 more
europepmc   +1 more source

L-Isoleucine production by analog-resistant mutants derived from threonine-producing strain of Corynebacterium glutamicum.

, 1977
Hiroshi Kase, Kiyoshi Nakayama
openalex   +2 more sources

Defining the polycystin pharmacophore through high‐throughput screening and computational biophysics

British Journal of Pharmacology, EarlyView.
An unbiased high throughput electrophysiology screen identifies potent PKD2L1 channel inhibitors with divergent chemical composition that bind to pore fenestration receptors and stabilise their inactivated state. Abstract Background and Purpose Polycystins (PKD2, PKD2L1) are voltage‐gated and Ca2+‐modulated members of the TRP family of ion channels ...
Eduardo Guadarrama, Carlos G. Vanoye, Paul G. DeCaen   +2 more
wiley   +1 more source

Apparent Saturation of Branched-Chain Amino Acid Catabolism After High Dietary Milk Protein Intake in Healthy Adults.

J Clin Endocrinol Metab
Newton-Tanzer E, Can SN, Demmelmair H, Horak J, Holdt L, Koletzko B, Grote V.   +6 more
europepmc   +1 more source

Effects of an angiotensin II antagonist; [sarcosine, isoleucine] angiotensin II, on blood pressure, plasma renin activity and plasma aldosterone concentration in hypertensive and normotensive subjects taking oral contraceptives.

, 1979
Toshio Ogihara, Takeshi Hata, Anna Maruyama, Mitsuaki Nakamaru, Hiroshi Mikami, Y Kumahara   +5 more
openalex   +2 more sources

Multi‐Omics Reveal the Metabolic Changes in Cumulus Cells During Aging

Cell Proliferation, EarlyView.
Fatty acid β‐oxidation was elevated in cumulus cells from older mice. Tryptophan metabolism in aged cumulus cells was active. Supplementing with 5‐HT could mitigate aging damage in oocytes. ABSTRACT Maternal age has been reported to impair oocyte quality.
Liangyue Shi, Hengjie Wang, Shuai Zhu, Minjian Chen, Xuejiang Guo, Qiang Wang, Ling Gu   +6 more
wiley   +1 more source