Results 311 to 320 of about 197,005 (375)

The toxic effects of meta‐tyrosine are related to its misincorporation into the proteome and to altered metabolism in cyanobacteria

The FEBS Journal, EarlyView.
This study reveals that meta‐tyrosine (m‐Tyr), a nonproteinogenic analog of aromatic amino acids, disrupts protein synthesis and photosynthesis in cyanobacteria by being misincorporated by Phenylalanyl‐tRNA synthetase (PheRS) into essential proteins. Through molecular, biochemical, and proteomic analyses in Synechocystis, the research shows that m‐Tyr ...
Hagit Zer, Roei Matan, David Rasin, Yoram Soroka, Noa Carmi, Hanan Schoffman, Nir Keren, Jörg Nickelsen, Oren Ostersetzer‐Biran   +8 more
wiley   +1 more source

The molecular mechanisms of defensive‐grade organic acid biosynthesis in ground beetles

Insect Molecular Biology, EarlyView.
Formic acid and methacrylic acid are the primary defensive chemicals in the pygidial gland secretions of Platynus angustatus and Pterostichus moestus, respectively. Comparative transcriptomics suggests the folate cycle and valine catabolism may be involved in the biosynthesis of formic acid and methacrylic acid, respectively.
Adam M. Rork, Sihang Xu, Athula Attygalle, Tanya Renner   +3 more
wiley   +1 more source

High yield purification of an isoleucine zipper-modified CD95 ligand for efficient cell apoptosis initiation and with biotin or DNA-oligomer binding domain to probe ligand functionalization effects. [PDF]

BMC Biotechnol
Shang X, Bartels N, Weck JM, Suppmann S, Basquin J, Thaventhiran G, Heuer-Jungemann A, Monzel C.   +7 more
europepmc   +1 more source

Serum proteomic and metabolomic analyses from patients with IBD identify biological pathways associated with treatment success with anti‐integrin therapy

Immunology &Cell Biology, EarlyView.
In this article, we have analyzed the serum proteome and metabolome in inflammatory bowel disease patients being treated with the anti‐α4β7 integrin therapeutic agent vedolizumab. The pretreatment biomarker profiles, as well as changes in biomarker profiles during treatment, identified likely pro‐inflammatory pathways associated with treatment response.
John D Rioux, Gabrielle Boucher, Anik Forest, Bertrand Bouchard, Lise Coderre, Caroline Daneault, Isabelle Robillard Frayne, Julie Thompson Legault, Alain Bitton, Ashwin Ananthakrishnan, Sylvie Lesage, Ramnik J Xavier, Christine Des Rosiers, iGenoMed Consortium, Alain Bitton, Gabrielle Boucher, Guy Charron, Christine Des Rosiers, Anik Forest, Philippe Goyette, Sabine Ivison, Lawrence Joseph, Rita Kohen, Jean Lachaine, Sylvie Lesage, Megan Levings, John D. Rioux, Julie Thompson Legault, Luc Vachon, Sophie Veilleux, Brian White‐Guay   +30 more
wiley   +1 more source

Association of metabolic dysregulation with treatment response in rectal cancer patients undergoing chemoradiotherapy. [PDF]

BMC Med Genomics
Peng Q, Shen Y, Xu Y, Feng Z, Xu Y, Wang Y, Zou L, Zhu Y, Shen Y.   +8 more
europepmc   +1 more source

Solanum bulbocastanum nucleotide‐binding leucine‐rich repeat receptor evolution reveals functional variants and critical residues in Rpi‐blb1/RB

Journal of Integrative Plant Biology, EarlyView.
Natural variants of the nucleotide‐binding leucine‐rich repeat protein Rpi‐blb1/RB in Solanum bulbocastanum recognize the Phytophthora infestans effector IPI‐O4, as well as two non‐functional variants. The S347N mutation disrupts IPI‐O1 recognition, Rpi‐blb1/RB self‐association and subcellular relocalisation, thereby compromising resistance.
Jie Li, Sophie Mantelin, Miles Armstrong, Amanpreet Kaur, Sonia Gomez, Jiahan Ying, Xiuli Qin, Kathryn M. Wright, Brian Harrower, Paolo Ribeca, Théo Chaumet, Gaynor McKenzie, Huanting Liu, Malcolm F White, Thomas Adams, Stuart Ronan Fisher, Daolong Dou, Xiaodan Wang, Ingo Hein   +18 more
wiley   +1 more source

Distinct phylogeographic distributions and frequencies of precore and basal core promoter mutations between HBV subgenotype C1 rt269L and rt269I types. [PDF]

Sci Rep
Kim DH, Choi YM, Jang J, Kim Z, Kim BJ.
europepmc   +1 more source

Metabolomic Profiles of Oral Rinse Samples to Distinguish Severe Periodontitis Patients From Non‐Periodontitis Controls

Journal of Periodontal Research, EarlyView.
Metabolomic fingerprints analyzed from oral rinses are able to distinguish between severe periodontitis (stage III/IV) patients and non‐periodontitis controls. ABSTRACT Aims To explore the potential of metabolomic profiles of oral rinse samples to distinguish between patients with severe periodontitis (stage III/IV) and non‐periodontitis controls. This
Madeline X. F. Kosho, Alessio Ciurli, Martin Giera, Jacques Neefjes, Bruno G. Loos   +4 more
wiley   +1 more source

Circulating amino acids and cardiometabolic risk profile in offspring of women with type 1 diabetes: cross-sectional case-control study. [PDF]

Sci Rep
Somersalo E, Kautiainen H, Klemetti MM, Eriksson JG, Laine MK.   +4 more
europepmc   +1 more source

Evidence of Intraspecific Adaptive Variation in the American Pika (Ochotona princeps) on a Continental Scale Using a Target Enrichment and Mitochondrial Genome Skimming Approach

Molecular Ecology, EarlyView.
ABSTRACT Montane landscapes present an array of abiotic challenges that drive adaptive evolution amongst organisms. These adaptations can promote habitat specialisation, which may heighten the risk of extirpation from environmental change. For example, higher metabolic rates in an endothermic species may contribute to heightened cold tolerance, whilst ...
Zachery M. Farrand, Kurt E. Galbreath, Katherine C. Teeter   +2 more
wiley   +1 more source