Results 1 to 10 of about 90,505 (292)

Ribulose-1,5-bisphosphate regeneration in the Calvin-Benson-Bassham cycle: Focus on the last three enzymatic steps that allow the formation of Rubisco substrate

Frontiers in Plant Science, 2023
The Calvin-Benson-Bassham (CBB) cycle comprises the metabolic phase of photosynthesis and is responsible for carbon fixation and the production of sugar phosphates.
Maria Meloni, Libero Gurrieri, Simona Fermani, Simona Fermani, Lauren Velie, Francesca Sparla, Pierre Crozet, Julien Henri, Mirko Zaffagnini   +8 more
doaj   +1 more source

Aromatic sulphonamides of aziridine-2-carboxylic acid derivatives as novel PDIA1 and PDIA3 inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
In this study, we report a series of newly synthesised sulphonamides of aziridine-2-carboxylic acid (Az-COOH) ester and amide analogues as potent protein disulphide isomerase (PDI, EC 5.3.4.1) inhibitors.
D. Zelencova-Gopejenko, V. Andrianov, I. Domracheva, I. Kanepe-Lapsa, M. Milczarek, M. Stojak, K. Przyborowski, F. A. Fedak, M. Walczak, K. Kramkowski, J. Wietrzyk, S. Chlopicki, I. Kalvins   +12 more
doaj   +1 more source

Biochemical and Structural Characterisation of a Novel D-Lyxose Isomerase From the Hyperthermophilic Archaeon Thermofilum sp.

Frontiers in Bioengineering and Biotechnology, 2021
A novel D-lyxose isomerase has been identified within the genome of a hyperthermophilic archaeon belonging to the Thermofilum species. The enzyme has been cloned and over-expressed in Escherichia coli and biochemically characterised.
Simone Antonio De Rose, Tom Kuprat, Michail N. Isupov, Andreas Reinhardt, Peter Schönheit, Jennifer A. Littlechild   +5 more
doaj   +1 more source

Over-Expression of LcPDS, LcZDS, and LcCRTISO, Genes From Wolfberry for Carotenoid Biosynthesis, Enhanced Carotenoid Accumulation, and Salt Tolerance in Tobacco

Frontiers in Plant Science, 2020
It is of great importance to combine stress tolerance and plant quality for breeding research. In this study, the role of phytoene desaturase (PDS), ζ-carotene desaturase (ZDS) and carotene isomerase (CRTISO) in the carotenoid biosynthesis are correlated
Chen Li, Jing Ji, Gang Wang, Zhaodi Li, Yurong Wang, Yajun Fan   +5 more
doaj   +1 more source

Ribose 5-phosphate isomerase B knockdown compromises Trypanosoma brucei bloodstream form infectivity. [PDF]

PLoS Neglected Tropical Diseases, 2015
Ribose 5-phosphate isomerase is an enzyme involved in the non-oxidative branch of the pentose phosphate pathway, and catalyzes the inter-conversion of D-ribose 5-phosphate and D-ribulose 5-phosphate.
Inês Loureiro, Joana Faria, Christine Clayton, Sandra Macedo-Ribeiro, Nuno Santarém, Nilanjan Roy, Anabela Cordeiro-da-Siva, Joana Tavares   +7 more
doaj   +1 more source

Repurposing of rabeprazole as an anti-Trypanosoma cruzi drug that targets cellular triosephosphate isomerase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Trypanosoma cruzi is the causative agent of American trypanosomiasis, which mainly affects populations in Latin America. Benznidazole is used to control the disease, with severe effects in patients receiving this chemotherapy.
Itzhel García-Torres, Ignacio De la Mora-De la Mora, Gabriel López-Velázquez, Nallely Cabrera, Luis Antonio Flores-López, Ingeborg Becker, Juliana Herrera-López, Roberto Hernández, Ruy Pérez-Montfort, Sergio Enríquez-Flores   +9 more
doaj   +1 more source

Exploring Castellaniella defragrans Linalool (De)hydratase-Isomerase for Enzymatic Hydration of Alkenes

Molecules, 2019
Acyclic monoterpenes constitute a large and highly abundant class of secondary plant metabolites and are, therefore, attractive low-cost raw materials for the chemical industry.
Matthias Engleder, Monika Müller, Iwona Kaluzna, Daniel Mink, Martin Schürmann, Erich Leitner, Harald Pichler, Anita Emmerstorfer-Augustin   +7 more
doaj   +1 more source

A Role of a Newly Identified Isomerase From Yarrowia lipolytica in Erythritol Catabolism

Frontiers in Microbiology, 2018
Erythritol is a natural sweetener produced by microorganisms as an osmoprotectant. It belongs to the group of polyols and it can be utilized by the oleaginous yeast Yarrowia lipolytica.
Aleksandra M. Mirończuk, Anna Biegalska, Karolina Zugaj, Dorota A. Rzechonek, Adam Dobrowolski   +4 more
doaj   +1 more source

Diversity oriented biosynthesis via accelerated evolution of modular gene clusters

Nature Communications, 2017
Reengineering polyketide synthase encoding genes to produce analogues of natural products can be slow and low-yielding. Here the authors use accelerated evolution to recombine the gene cluster for rapid production of rapamycin-related products.
Aleksandra Wlodek, Steve G. Kendrew, Nigel J. Coates, Adam Hold, Joanna Pogwizd, Steven Rudder, Lesley S. Sheehan, Sarah J. Higginbotham, Anna E. Stanley-Smith, Tony Warneck, Mohammad Nur-E-Alam, Markus Radzom, Christine J. Martin, Lois Overvoorde, Markiyan Samborskyy, Silke Alt, Daniel Heine, Guy T. Carter, Edmund I. Graziani, Frank E. Koehn, Leonard McDonald, Alexander Alanine, Rosa María Rodríguez Sarmiento, Suzan Keen Chao, Hasane Ratni, Lucinda Steward, Isobel H. Norville, Mitali Sarkar-Tyson, Steven J. Moss, Peter F. Leadlay, Barrie Wilkinson, Matthew A. Gregory   +31 more
doaj   +1 more source

Structural and Functional Insights into Human Nuclear Cyclophilins

Biomolecules, 2018
The peptidyl prolyl isomerases (PPI) of the cyclophilin type are distributed throughout human cells, including eight found solely in the nucleus. Nuclear cyclophilins are involved in complexes that regulate chromatin modification, transcription, and pre ...
Caroline Rajiv, Tara L. Davis
doaj   +1 more source