Results 1 to 10 of about 98,929 (291)

Inhibition of protein disulfide isomerase induces differentiation of acute myeloid leukemia cells [PDF]

Haematologica, 2018
A cute myeloid leukemia is a malignant disease of immature myeloid cells. Despite significant therapeutic effects of differentiation-inducing agents in some acute myeloid leukemia subtypes, the disease remains incurable in a large fraction of patients ...
Justyna Chlebowska-Tuz, Olga Sokolowska, Pawel Gaj, Michal Lazniewski, Malgorzata Firczuk, Karolina Borowiec, Hanna Sas-Nowosielska, Malgorzata Bajor, Agata Malinowska, Angelika Muchowicz, Kavita Ramji, Piotr Stawinski, Mateusz Sobczak, Zofia Pilch, Anna Rodziewicz-Lurzynska, Malgorzata Zajac, Krzysztof Giannopoulos, Przemyslaw Juszczynski, Grzegorz W. Basak, Dariusz Plewczynski, Rafal Ploski, Jakub Golab, Dominika Nowis   +22 more
doaj   +2 more sources

Thiol Isomerases: Enzymatic Mechanisms, Models of Oxidation, and Antagonism by Galloylated Polyphenols [PDF]

Antioxidants
Thiol isomerases are a family of enzymes that participate in oxidative protein folding. They contain highly reactive vicinal thiols in a CXXC motif within their catalytic domains to mediate thiol-disulfide switching as part of their reductase, oxidase ...
Osamede C. Owegie, Quinn P. Kennedy, Pavel Davizon-Castillo, Moua Yang   +3 more
doaj   +2 more sources

Ribulose-1,5-bisphosphate regeneration in the Calvin-Benson-Bassham cycle: Focus on the last three enzymatic steps that allow the formation of Rubisco substrate

Frontiers in Plant Science, 2023
The Calvin-Benson-Bassham (CBB) cycle comprises the metabolic phase of photosynthesis and is responsible for carbon fixation and the production of sugar phosphates.
Maria Meloni, Libero Gurrieri, Simona Fermani, Simona Fermani, Lauren Velie, Francesca Sparla, Pierre Crozet, Julien Henri, Mirko Zaffagnini   +8 more
doaj   +1 more source

First Reported Case of Glucose-6-Phosphate Isomerase Deficiency in a Saudi Child With Hemolytic Anemia. [PDF]

Cureus
Alotaibi W, Wafa S, Elzubair L, Abualama A, Alasmari BG.   +4 more
europepmc   +3 more sources

Aromatic sulphonamides of aziridine-2-carboxylic acid derivatives as novel PDIA1 and PDIA3 inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
In this study, we report a series of newly synthesised sulphonamides of aziridine-2-carboxylic acid (Az-COOH) ester and amide analogues as potent protein disulphide isomerase (PDI, EC 5.3.4.1) inhibitors.
D. Zelencova-Gopejenko, V. Andrianov, I. Domracheva, I. Kanepe-Lapsa, M. Milczarek, M. Stojak, K. Przyborowski, F. A. Fedak, M. Walczak, K. Kramkowski, J. Wietrzyk, S. Chlopicki, I. Kalvins   +12 more
doaj   +1 more source

Mutasynthesis of C17- and C21-Substituted Ansamitocins for Use as ADC Payloads [PDF]

ACS Omega
Anna E. Stanley-Smith, Nigel Coates, James C. Fox, Frank Delfino, Sylvia Degrado, Arthur Kunz, Shu Mao, Feng Zhao, Ben Garforth, Adam Hold, Hui Hong, John Kendall, Jessica Lane, Coline Meï, Annabel Murphy, Joanna Pogwizd, Celia Ruiz Escobar, Benjamin Wertz, Steven J. Moss, Matthew A. Gregory, Thomas Nittoli   +20 more
doaj   +2 more sources

Biochemical and Structural Characterisation of a Novel D-Lyxose Isomerase From the Hyperthermophilic Archaeon Thermofilum sp.

Frontiers in Bioengineering and Biotechnology, 2021
A novel D-lyxose isomerase has been identified within the genome of a hyperthermophilic archaeon belonging to the Thermofilum species. The enzyme has been cloned and over-expressed in Escherichia coli and biochemically characterised.
Simone Antonio De Rose, Tom Kuprat, Michail N. Isupov, Andreas Reinhardt, Peter Schönheit, Jennifer A. Littlechild   +5 more
doaj   +1 more source

Over-Expression of LcPDS, LcZDS, and LcCRTISO, Genes From Wolfberry for Carotenoid Biosynthesis, Enhanced Carotenoid Accumulation, and Salt Tolerance in Tobacco

Frontiers in Plant Science, 2020
It is of great importance to combine stress tolerance and plant quality for breeding research. In this study, the role of phytoene desaturase (PDS), ζ-carotene desaturase (ZDS) and carotene isomerase (CRTISO) in the carotenoid biosynthesis are correlated
Chen Li, Jing Ji, Gang Wang, Zhaodi Li, Yurong Wang, Yajun Fan   +5 more
doaj   +1 more source

Ribose 5-phosphate isomerase B knockdown compromises Trypanosoma brucei bloodstream form infectivity. [PDF]

PLoS Neglected Tropical Diseases, 2015
Ribose 5-phosphate isomerase is an enzyme involved in the non-oxidative branch of the pentose phosphate pathway, and catalyzes the inter-conversion of D-ribose 5-phosphate and D-ribulose 5-phosphate.
Inês Loureiro, Joana Faria, Christine Clayton, Sandra Macedo-Ribeiro, Nuno Santarém, Nilanjan Roy, Anabela Cordeiro-da-Siva, Joana Tavares   +7 more
doaj   +1 more source

A Role of a Newly Identified Isomerase From Yarrowia lipolytica in Erythritol Catabolism

Frontiers in Microbiology, 2018
Erythritol is a natural sweetener produced by microorganisms as an osmoprotectant. It belongs to the group of polyols and it can be utilized by the oleaginous yeast Yarrowia lipolytica.
Aleksandra M. Mirończuk, Anna Biegalska, Karolina Zugaj, Dorota A. Rzechonek, Adam Dobrowolski   +4 more
doaj   +1 more source