Results 91 to 100 of about 196,977 (320)
FKBP51 employs both scaffold and isomerase functions to promote NF-κB activation in melanoma
Nucleic Acids Research, 2015 Melanoma is the most aggressive skin cancer; its prognosis, particularly in advanced stages, is disappointing largely due to the resistance to conventional anticancer treatments and high metastatic potential.
S. Romano +10 more
semanticscholar +1 more source
AS‐pHopt: An Optimal pH Prediction Model Enhanced by Active Site of Enzymes
Advanced Intelligent Discovery, EarlyView.To address the low accuracy of enzyme optimal pH (pHopt) prediction, this study develops active site‐based pHopt (AS‐pHopt), a prediction model enhanced by active site information and pseudo‐label prediction. Integrating key structural and physicochemical features affecting enzyme pHopt, AS‐pHopt uses Evolutionary Scale Modeling (ESM)‐2 with active ...
Wenxiang Song +6 more
wiley +1 more source
FK 506 pre-treatment is associated with reduced levels of tumor necrosis factor and interleukin 6 following hepatic ischemia/reperfusion [PDF]
, 1993 Using a rat model, the effect of pre-treatment with FK 506 on hepatic ischemia/reperfusion injury was investigated. All control animals died within 72 h of the ischemia/reperfusion injury.
Aarden +64 more
core +1 more source
Advanced NanoBiomed Research, EarlyView.This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari +5 more
wiley +1 more source
Arginyltransferase, Its Specificity, Putative Substrates, Bidirectional Promoter, and Splicing-derived Isoforms [PDF]
, 2006 Substrates of the N-end rule pathway include proteins with destabilizing N-terminal residues. Three of them, Asp, Glu, and (oxidized) Cys, function through their conjugation to Arg, one of destabilizing N-terminal residues that are recognized directly by
Brower, Christopher S. +7 more
core +2 more sources
Applications in Plant Sciences, EarlyView.Abstract Premise Cell suspension cultures of Douglas‐fir (Pseudotsuga menziesii) nucellus were created to overcome phenological limitations to the in situ study of bioactive proteins within and secreted by nucellar cells. Methods Proteins isolated from the cell suspension culture medium were analyzed using mass spectrometry, as were Douglas‐fir post ...
Andrea Coulter +4 more
wiley +1 more source
Engineering the xylose metabolism in Schizochytrium sp. to improve the utilization of lignocellulose
Biotechnology for Biofuels and Bioproducts, 2022 Background Schizochytrium sp. is a heterotrophic, oil-producing microorganism that can efficiently produce lipids. However, the industrial production of bulk chemicals using Schizochytrium sp.
Ling-Ru Wang +7 more
doaj +1 more source
Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State [PDF]
, 2016 The mitochondrial thioredoxin system (NADPH, thioredoxin reductase, thioredoxin) is a major redox regulator. Here we have investigated the redox correlation between this system and the mitochondrial enzyme cyclophilin D.
Bindoli, Alberto +7 more
core +1 more source
A Metagenome‐Assembled Genome Catalog From the Global Ruminant Microbiomes
Animal Research and One Health, EarlyView.The Ruminant Gastrointestinal MAG Catalog (RGMC) is a comprehensive global resource offering 40,812 strain‐level genomes across 53 bacterial and 4 archaeal classes. It greatly surpasses prior efforts in scale and diversity, serving as an essential foundation for research in ruminant nutrition, microbial function, and methane mitigation.
Shizhe Zhang +8 more
wiley +1 more source
Isomerisasi 1-buten Menggunakan Zeolit Alam asal Malang, Jawa Timur, sebagai Katalis
Journal of Mathematical and Fundamental Sciences, 2019 Sari. Isomerisasi l-buten dengan katalis zeolit alam asal Malang, Jawa Timur, dilangsungkan dalam reaktor isotermal unggun tetap dengar suhu divariasikan antara 300° dan 550°C.
Melia Laniwati
doaj