Results 31 to 40 of about 90,505 (292)

Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors

eLife, 2016
Missense mutations in ATM kinase, a master regulator of DNA damage responses, are found in many cancers, but their impact on ATM function and implications for cancer therapy are largely unknown.
Kenta Yamamoto, Jiguang Wang, Lisa Sprinzen, Jun Xu, Christopher J Haddock, Chen Li, Brian J Lee, Denis G Loredan, Wenxia Jiang, Alessandro Vindigni, Dong Wang, Raul Rabadan, Shan Zha   +12 more
doaj   +1 more source

Screening of Xylanase and Glucose Isomerase Producing Bacteria Isolated from Hot Springs in Turkey

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2018
Theaim of this study was screening of xylanase and glucose isomerase producingthermophilic bacteria isolated from some hot springs located to Aegean Regionof Turkey.
Muslum Tokgoz, Dilsat Nigar Colak, Kadriye Inan Bektas, Sabriye Canakcı, Ali Osman Belduz   +4 more
doaj   +1 more source

Analysis of Chalcone Synthase and Chalcone Isomerase Gene Expression in Pigment Production Pathway at Different Flower Colors of Petunia Hybrida [PDF]

Journal of Cell and Molecular Research, 2016
Variegation in flower color is commonly observed in many plant species and also occurs on petunia (Petunia hybrida) as an ornamental plant. Variegated plants are highly valuable in the floricultural market.
fatemeh keykha, Abdol Reza Bagheri, Nasrin Moshtaghi   +2 more
doaj   +1 more source

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

Molecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul, François Guillonneau, Odile Blanchet, Hamza Lasla, Audrey Rousseau, Catherine Guette, Alice Boissard, Cécile Henry, Morgan Dhondt, Pascal Jézéquel, Philippe Menei, Jean‐Michel Lemée   +11 more
wiley   +1 more source

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

FEBS Open Bio, EarlyView.
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Claudia Valentina Popa, Simona Ghenea, Ileana Cornelia Farcasanu   +4 more
wiley   +1 more source

Metal‐Responsive Up‐Regulation of Bifunctional Disulfides for Suppressing Protein Misfolding and Promoting Oxidative Folding

Angewandte Chemie, EarlyView.
A stress‐responsive folding promotor was developed by conjugating metal‐binding ligands and a redox‐active disulfide. The oxidative strength of the bifunctional disulfide was enhanced by metal coordination, inhibiting protein misfolding and up‐regulating the oxidative folding capacity under metal stress.
Keita Mori, Tsubura Kuramochi, Motonori Matsusaki, Yuki Hashiguchi, Masaki Okumura, Tomohide Saio, Yoshiaki Furukawa, Kenta Arai, Takahiro Muraoka   +8 more
wiley   +2 more sources

Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis

Cells, 2019
Hepatic fibrosis can result as a pathological response to nonalcoholic steatohepatitis (NASH). Cirrhosis, the late stage of fibrosis, has been linked to poor survival and an increased risk of developing hepatocellular carcinoma, with limited treatment ...
Sonia Simón Serrano, Alvar Grönberg, Lisa Longato, Krista Rombouts, Joseph Kuo, Matthew Gregory, Steven Moss, Eskil Elmér, Giuseppe Mazza, Philippe Gallay, Massimo Pinzani, Magnus J. Hansson, Ramin Massoumi   +12 more
doaj   +1 more source

Isolation and Screening of Aspergillus niger and Bacillus coagulans as Potential Candidates for Amylase and Glucose Isomerase Production

UMYU Journal of Microbiology Research, 2022
There is an increasing demand for high fructose corn syrup as an alternative to glucose especially for use by people with diabetes due to its low glycemic index.
Musa, B., Zangina, B. U., Ado, S. A., Hussaini, I. M., Madika, A., Aliyu, M. S.   +5 more
doaj   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

XYLOSE ISOMERASE SYNTHESIS IN ACTINOBACTERIA ARTHROBACTER UREAFACIENS BIM B-6

Mìkrobìologìâ ì Bìotehnologìâ, 2008
The role of different carbon sources in biosynthesis of cell-bound xylose isomerase by Arthrobacter ureafaciens BIM B-6 was investigated. It was found that in this prokaryotic actinobacterium enzyme production is under control of induction and catabolite
Л. І. Сапунова
doaj   +1 more source