Results 51 to 60 of about 90,505 (292)

Phytophthora Disrupts Plant Immunity by Manipulating Nitric Oxide Homeostasis Through GSNOR Inhibition

Advanced Science, EarlyView.
Phytophthora capsici effector PcRD18 targets tomato GSNOR to disrupt NO homeostasis, promoting S‐nitrosylation of immune proteins like RBOHD. This suppresses ROS bursts and promotes pathogen infection. Mutation of the PcRD18‐binding sites of GSNOR avoids pathogen manipulation and offers a strategy to enhance crop resistance. Abstract Nitric oxide (NO),
Tingting Li, Jing Kang, Haizhu Zhang, Lina Wang, Minghui Lu, Lin Cai, Jianming Li, Matthieu H. A. J. Joosten, Yu Du   +8 more
wiley   +1 more source

Isomerisasi 1-buten Menggunakan Zeolit Alam asal Malang, Jawa Timur, sebagai Katalis

Journal of Mathematical and Fundamental Sciences, 2019
Sari. Isomerisasi l-buten dengan katalis zeolit alam asal Malang, Jawa Timur, dilangsungkan dalam reaktor isotermal unggun tetap dengar suhu divariasikan antara 300° dan 550°C.
Melia Laniwati
doaj  

rapid detection for the inhibition of phosphoglucose isomerase from Escherichia coli by mercury(II) chloride based on TLC-autographic analysis – preliminary studies

Current Issues in Pharmacy and Medical Sciences, 2014
The quest for new techniques for screening inhibitors of phosphoglucose isomerase is crucially important owing to therapeutic control of chronic bacterial infections associated with the biosynthesis of bacterial biofilm.
Paradowska Katarzyna, Lutek Joanna, Ginalska Grazyna   +2 more
doaj   +1 more source

HPD is an RNA‐Binding Protein Sustaining Ovarian Cancer Cell Glycolysis, Tumor Growth, and Drug Resistance

Advanced Science, EarlyView.
HPD is identified as an RNA‐binding protein that promotes mRNA translation by binding to RRACH motifs via its double‐stranded RNA‐binding domains. This RNA‐binding activity critically sustains glycolysis in ovarian cancer cells. Disrupting HPD's RNA‐binding function effectively suppresses tumor growth and enhances therapeutic sensitivity, highlighting ...
Fei Xie, Han Zhang, Xintong Dai, Mengxin Tu, Chenxi Yu, Lumeng Liu, Yajuan Guo, Huanran Sun, Qingle Gao, Jiyan Wang, Mingming Sun, Qijun Zhang, Taoyuan Wang, Tao He, Zhen Li, Yanping Li, Tao Wang, Jianguo Zhao, Zhongjie Chen, Chunze Zhang, Shuai Zhang, Changliang Shan   +21 more
wiley   +1 more source

Crystal structure and substrate specificity of D-galactose-6-phosphate isomerase complexed with substrates. [PDF]

PLoS ONE, 2013
D-Galactose-6-phosphate isomerase from Lactobacillus rhamnosus (LacAB; EC 5.3.1.26), which is encoded by the tagatose-6-phosphate pathway gene cluster (lacABCD), catalyzes the isomerization of D-galactose-6-phosphate to D-tagatose-6-phosphate during ...
Woo-Suk Jung, Raushan Kumar Singh, Jung-Kul Lee, Cheol-Ho Pan   +3 more
doaj   +1 more source

WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang, Qi You, Jiawei Liu, Xuguang Shen, Dengjun Huang, Xinlu Tao, Zhijie He, Chengwei Wu, Xinran Xi, Shouqiang Yu, Feng Liu, Zhihao Wu, Wenjun Mao, Shaojin Zhu   +13 more
wiley   +1 more source

The peptidyl prolyl cis/trans isomerase Pin1/Ess1 inhibits phosphorylation and toxicity of tau in a yeast model for Alzheimer’s disease

AIMS Molecular Science, 2015
Since hyperphosphorylation of protein tau is a crucial event in Alzheimer’s disease, additional mechanisms besides the interplay of kinase and phosphatase activities are investigated, such as the effect of the peptidyl prolyl cis/trans isomerase Pin1 ...
Ann De Vos, Tine Bynens, Joëlle Rosseels, Catherina Coun, Julia Ring, Frank Madeo, Marie-Christine Galas, Joris Winderickx, Vanessa Franssens   +8 more
doaj   +1 more source

Biosynthese des Rotalgen‐Diterpens Peyssonnosol in Bakterien

Angewandte Chemie, EarlyView.
Zwei Terpensynthasen aus Anaerolineae‐Bakterien katalysieren die Biosynthese von Peyssonnosen‐artigen Diterpenen aus Rotalgen. Ortsgerichtete Mutagenese ermöglichte einen partiellen Funktionswechsel, der zur Bildung zusätzlicher Nebenprodukte führte.
Zhiyong Yin, Zhehui Hu, Kexin Yang, Guihu Lu, Georges B. Tabekoueng, Pingping Wu, Qi Luo, Juan Xu, Bernd Goldfuss, Jeroen S. Dickschat, Guangkai Bian   +10 more
wiley   +1 more source

Protein disulfide isomerase a multifunctional protein with multiple physiological roles

Frontiers in Chemistry, 2014
Protein disulfide isomerase (PDI), is a member of the thioredoxin superfamily of redox proteins. PDI has three catalytic activities including, thiol-disulfide oxireductase, disulfide isomerase and redox-dependent chaperone.
Hyder eAli Khan, Bulent eMutus
doaj   +1 more source

Basic surface features of nuclear FKBPs facilitate chromatin binding

Scientific Reports, 2017
The nucleoplasmin family of histone chaperones is identified by a pentamer-forming domain and multiple acidic tracts that mediate histone binding and chaperone activity.
Andrew Leung, Francy-Pesek Jardim, Neda Savic, Yoan R. Monneau, Rodrigo González-Romero, Geoff Gudavicius, Jose M. Eirin-Lopez, Till Bartke, Cameron D. Mackereth, Juan Ausió, Christopher J. Nelson   +10 more
doaj   +1 more source