Results 91 to 100 of about 403,555 (400)

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Roles of the tyrosine isomers meta-tyrosine and ortho-tyrosine in oxidative stress

Ageing Research Reviews, 2016
The damage to cellular components by reactive oxygen species, termed oxidative stress, both increases with age and likely contributes to age-related diseases including Alzheimer’s disease, atherosclerosis, diabetes, and cataract formation. In the setting
Brett R. Ipson, Alfred L. Fisher
semanticscholar   +1 more source

Effect of Alkyl Chain Length on the Bandgap, Ferroelectric, and Photoelectric Properties of Lead‐Based Molecular Ferroelectrics

Advanced Science, EarlyView.
This study develops a novel 2D molecular ferroelectric [C6N2H18]PbI4 with polarization enhanced photovoltaics. It systematically investigates the effect of alkylamine spacer cation chain lengths on the band gap, ferroelectric, and photoelectric properties, offering new design strategies.
Ganghua Zhang, Jinrong Wen, Ping Chen, Zhibo Chen, Pingying Tang, Dezeng Li, Jingshan Hou, Yongzheng Fang   +7 more
wiley   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

A Mass Spectrometry Approach Reveals Fatty Acid Isomerism in Tomato Cold Tolerance

Advanced Science
Plants can adapt to environmental fluctuations through modulating their fatty acids (FAs) dynamically. In this study, an enhanced mass spectrometry approach is utilized to uncover an unexplored landscape of FAs and FA isomers that are critical for cold ...
Leelyn Chong, Hengxue Shi, Qirui Yu, Xiaoning Shi, Zhaoxing Jia, Ziyun Dong, Yu Xia, Yingfang Zhu   +7 more
doaj   +1 more source

Icosahedral metallic nanoclusters: low-temperature structures or pre-melting ones?

Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов
Melting of cuboctahedral nanoclusters of fcc metals (Ag, Au, Cu, Ni, Pd и Pt) containing 561 atoms and a transition to icosahedral isomers preceding their melting were simulated using the isothermal molecular dynamics.
I.V. Karakeyan, V.V. Puitov, I.V. Talyzin, V.M. Samsonov   +3 more
doaj   +1 more source

Biological Activities of a-Pinene and β-Pinene Enantiomers

Molecules, 2012
The antimicrobial activities of the isomers and enantiomers of pinene were evaluated against bacterial and fungal cells. The agar diffusion test showed that only the positive enantiomers of the a- and β-isomers of pinene were active.
Danielle Cristina Machado Costa, Daniela Sales Alviano, Celuta Sales Alviano, Mariana Maria Barros de Azevedo, Paula Monteiro Lopes, Ana Cristina Rivas da Silva   +5 more
doaj   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Characterization of Crocetin Isomers in Serum Samples via UHPLC-DAD-MS/MS and NMR after Saffron Extract (Safr’Inside™) Consumption

Metabolites
The therapeutic effects of saffron have been reported and described in relation to its major derivatives. Among them, in terms of saffron’s properties, crocin and crocetin absorption and bioavailability have been the most studied.
Adeline Vignault, Carole Vaysse, Karène Bertand, Stéphanie Krisa, Arnaud Courtois, Benjamin Moras, Tristan Richard, David Gaudout, Line Pourtau   +8 more
doaj   +1 more source

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source