Results 41 to 50 of about 45,359 (121)

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Global and regional impacts of land cover changes on isoprene emissions derived from spaceborne data and the MEGAN model

, 2021
. Among the biogenic volatile organic compounds (BVOCs) emitted by plant foliage, isoprene is by far the most important in terms of both global emission and atmospheric impact.
Beata Opacka, J. Müller, T. Stavrakou, M. Bauwens, K. Šindelářová, Jana Marková, A. Guenther   +6 more
semanticscholar   +1 more source

Remodeling of the terpenoid metabolism during prolonged phosphate depletion in the marine diatom Phaeodactylum tricornutum

Journal of Phycology, Volume 61, Issue 3, Page 512-528, June 2025.
Abstract Terpenoids are a diverse class of naturally occurring organic compounds, which derive from five‐carbon isoprene units and play crucial roles in physiology, ecological interactions such as defense mechanisms, or adaptation to environmental stresses.
Florian Pruckner, Luca Morelli, Payal Patwari, Michele Fabris   +3 more
wiley   +1 more source

Recent Advances in Functionalized Isocyanide Synthesis and Natural Products Containing the Isocyano Functional Group and Their Biological Properties

ChemistrySelect, Volume 10, Issue 16, April 25, 2025.
One important strategy to increase the versatility of isocyanides is to employ functionalized isocyanides. It should be mentioned that after being functionalized, isocyanides can precisely regulate their reactivity during a chemical reaction. Natural occurring isocyanides exhibit distinct biosynthetic pathways, and understanding these pathways sheds ...
Sodeeq Aderotimi Salami, Dele Abdissa, Simnikiwe Nogqala, Omotayo Esther Adeyanju, Shubham Sharma, Xavier Siwe‐Noundou, Rui W. M. Krause   +6 more
wiley   +1 more source

Compartmentalized Sesquiterpenoid Biosynthesis and Functionalization in the Chlamydomonas reinhardtii Plastid

ChemBioChem, Volume 26, Issue 5, March 3, 2025.
Photosynthetic microalgae were engineered for compartmentalized sesquiterpenoid biosynthesis by targeting synthases and cytochrome P450s to the chloroplast. The plastid's electron transport chain drives P450‐mediated oxidation without reductase partners, enabling production of complex functionalized terpenes.
Sergio Gutiérrez, Sebastian Overmans, Gordon B. Wellman, Kyle J. Lauersen   +3 more
wiley   +1 more source

Natural pigments derived from plants and microorganisms: classification, biosynthesis, and applications

Plant Biotechnology Journal, Volume 23, Issue 2, Page 592-614, February 2025.
Summary Pigments, as coloured secondary metabolites, endow the world with a rich palette of colours. They primarily originate from plants and microorganisms and play crucial roles in their survival and adaptation processes. In this article, we categorize pigments based on their chemical structure into flavonoids, carotenoids, pyrroles, quinones ...
Qian Tang, Zhibo Li, Ningxin Chen, Xiaozhou Luo, Qiao Zhao   +4 more
wiley   +1 more source

Non‐Canonical C16 Homoterpene Biosynthesis Widespread in Actinobacteria

Angewandte Chemie International Edition, Volume 64, Issue 5, January 27, 2025.
The first biosynthetic pathway to C16 homoterpenes in actinobacteria is reported. A novel methyltransferase family mediates methylation and double bond isomerization to produce a modified C16 precursor. Subsequent conversion by a distinct terpene cyclase family yields unprecedented homoterpenes. The findings enable the development of novel biocatalytic
Tatjana Reuter, Lars Dieminger, Sarah Steidle, Katrin Zoller, Maximilian Holocher, Lin Zhou, Dominik Matthias Hanauska, Katharina Racz, Lena Barra   +8 more
wiley   +1 more source

Inhibition of Ammonia Monooxygenase from Ammonia-Oxidizing Archaea by Linear and Aromatic Alkynes

Applied and Environmental Microbiology, 2020
Archaeal and bacterial ammonia oxidizers (AOA and AOB, respectively) initiate nitrification by oxidizing ammonia to hydroxylamine, a reaction catalyzed by ammonia monooxygenase (AMO).
Chloë L. Wright, Arne Schatteman, A. Crombie, J. Murrell, L. Lehtovirta-Morley   +4 more
semanticscholar   +1 more source

Antarctic Geothermal Soils Exhibit an Absence of Regional Habitat Generalist Microorganisms

Environmental Microbiology, Volume 27, Issue 1, January 2025.
Antarctic geothermal sites are highly isolated islands of warmth and moisture. We studied the community structure, predicted functions and ecology of the microorganisms inhabiting these sites, with the finding that high dispersal rates have resulted in an absence of regional habitat generalists between these sites.
Stephen E. Noell, Jaber Abbaszadeh, Huw Richards, Marie Labat Saint Vincent, Charles K. Lee, Craig W. Herbold, Matthew B. Stott, S. Craig Cary, Ian R. McDonald   +8 more
wiley   +1 more source

Particulate methane monooxygenase contains only mononuclear copper centers

Science, 2019
How many metals to oxidize methane? Methane is an important fuel, but there are few direct transformations to partially oxidized products. Bacteria use metalloenzymes to catalyze methane oxidation to methanol, a reaction of industrial interest ...
Matthew O. Ross, F. MacMillan, Jingzhou Wang, Alex Nisthal, T. Lawton, B. D. Olafson, S. L. Mayo, A. Rosenzweig, B. Hoffman   +8 more
semanticscholar   +1 more source