Results 21 to 30 of about 54 (48)

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Haloalkalitolerant Nitrile‐Utilizing Rhodococcus Strains Promote the Biodegradation of Nitrile‐Butadiene Rubber

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Environmental pollution from polymers is reaching alarming levels. Nitrile‐butadiene rubber (NBR), widely used in medical glove manufacturing, contributes significantly to plastic and microplastic pollution. Nitrile gloves have become a major component of COVID‐19 pandemic‐related waste. In this study, we demonstrated the ability of haloalkalitolerant,
G. A. Syrovatskaya, A. Yu. Maksimov, O. V. Korotchenkova, Yu. G. Maksimova, Swaran J. S. Flora   +4 more
wiley   +1 more source

Homoterpene Biosynthesis in Fungi

Angewandte Chemie International Edition, Volume 64, Issue 52, December 22, 2025.
The first homoterpene biosynthetic pathway in the fungal kingdom is reported. A methyltransferase–terpene cyclase pair produces a unique heptamethyl bicyclo[3.3.1]nonane homoterpene via presodorifen, demonstrating that homoterpene biosynthesis via the addition of a C1 unit to terpene diphosphate precursors prior to scaffold formation extends beyond the
Lin Zhou, Tatjana Reuter, Kiara Schumann, Markus Mayer, Dominik Matthias Hanauska, Lena Barra   +5 more
wiley   +1 more source

Anaerobic Limonene Metabolism in a Methanogenic Enrichment Involves a Glycine Radical Enzyme

Environmental Microbiology, Volume 27, Issue 11, November 2025.
A methanogenic enrichment culture on the natural monoterpene limonene is characterised by a novel glycine radical enzyme for anaerobic hydrocarbon activation, the presence of a microbial loop for necromass utilisation and the presence of a predator of Bacteria and Archaea. ABSTRACT Limonene is a natural monoterpene omnipresent in human environments. It
Almud Lonsing, Gerrit Alexander Martens, Anastasia Resteu, Jana Kizina, Isabella Wilkie, Alexandra Bahr, Jens Harder   +6 more
wiley   +1 more source

Remodeling of the terpenoid metabolism during prolonged phosphate depletion in the marine diatom Phaeodactylum tricornutum

Journal of Phycology, Volume 61, Issue 3, Page 512-528, June 2025.
Abstract Terpenoids are a diverse class of naturally occurring organic compounds, which derive from five‐carbon isoprene units and play crucial roles in physiology, ecological interactions such as defense mechanisms, or adaptation to environmental stresses.
Florian Pruckner, Luca Morelli, Payal Patwari, Michele Fabris   +3 more
wiley   +1 more source

Recent Advances in Functionalized Isocyanide Synthesis and Natural Products Containing the Isocyano Functional Group and Their Biological Properties

ChemistrySelect, Volume 10, Issue 16, April 25, 2025.
One important strategy to increase the versatility of isocyanides is to employ functionalized isocyanides. It should be mentioned that after being functionalized, isocyanides can precisely regulate their reactivity during a chemical reaction. Natural occurring isocyanides exhibit distinct biosynthetic pathways, and understanding these pathways sheds ...
Sodeeq Aderotimi Salami, Dele Abdissa, Simnikiwe Nogqala, Omotayo Esther Adeyanju, Shubham Sharma, Xavier Siwe‐Noundou, Rui W. M. Krause   +6 more
wiley   +1 more source

Compartmentalized Sesquiterpenoid Biosynthesis and Functionalization in the Chlamydomonas reinhardtii Plastid

ChemBioChem, Volume 26, Issue 5, March 3, 2025.
Photosynthetic microalgae were engineered for compartmentalized sesquiterpenoid biosynthesis by targeting synthases and cytochrome P450s to the chloroplast. The plastid's electron transport chain drives P450‐mediated oxidation without reductase partners, enabling production of complex functionalized terpenes.
Sergio Gutiérrez, Sebastian Overmans, Gordon B. Wellman, Kyle J. Lauersen   +3 more
wiley   +1 more source

Phylogenetic and Functional Diversity of Soluble Di‐Iron Monooxygenases

Environmental Microbiology, Volume 27, Issue 2, February 2025.
Relationships between monooxygenase substrates and products with respect to host cell physiology and biotechnology applications. ABSTRACT Monooxygenase (MO) enzymes are responsible for the oxidation of hydrocarbons and other compounds in the carbon and nitrogen cycles, are important for the biodegradation of pollutants and can act as biocatalysts for ...
Sui Nin Nicholas Yang, Michael A. Kertesz, Nicholas V. Coleman   +2 more
wiley   +1 more source

Natural pigments derived from plants and microorganisms: classification, biosynthesis, and applications

Plant Biotechnology Journal, Volume 23, Issue 2, Page 592-614, February 2025.
Summary Pigments, as coloured secondary metabolites, endow the world with a rich palette of colours. They primarily originate from plants and microorganisms and play crucial roles in their survival and adaptation processes. In this article, we categorize pigments based on their chemical structure into flavonoids, carotenoids, pyrroles, quinones ...
Qian Tang, Zhibo Li, Ningxin Chen, Xiaozhou Luo, Qiao Zhao   +4 more
wiley   +1 more source

Non‐Canonical C16 Homoterpene Biosynthesis Widespread in Actinobacteria

Angewandte Chemie International Edition, Volume 64, Issue 5, January 27, 2025.
The first biosynthetic pathway to C16 homoterpenes in actinobacteria is reported. A novel methyltransferase family mediates methylation and double bond isomerization to produce a modified C16 precursor. Subsequent conversion by a distinct terpene cyclase family yields unprecedented homoterpenes. The findings enable the development of novel biocatalytic
Tatjana Reuter, Lars Dieminger, Sarah Steidle, Katrin Zoller, Maximilian Holocher, Lin Zhou, Dominik Matthias Hanauska, Katharina Racz, Lena Barra   +8 more
wiley   +1 more source