Results 1 to 10 of about 56,118 (235)

Exposure to Doxorubicin Modulates the Cardiac Response to Isoproterenol in Male and Female Mice

Pharmaceuticals, 2023
Sex is a salient risk factor in the development of doxorubicin-induced cardiotoxicity. Sex differences in the heart’s ability to respond to hypertrophic stimuli in doxorubicin-exposed animals have not been reported.
Kevin Agostinucci, Marianne K. O. Grant, Wongel Melaku, Chandini Nair, Beshay N. Zordoky   +4 more
doaj   +1 more source

The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist [PDF]

, 2013
Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the ...
Andresen, Bradley T., Bastepe, Murat, Blessing, Christopher P., Erickson, Catherine E., Gul, Rukhsana, Holowka, David, Jackson, Edwin K., Liu, Tammy, Nguyen, Jenny, Pulakat, Lakshmi   +9 more
core   +10 more sources

Klotho suppresses cardiomyocyte apoptosis in mice with stress-induced cardiac injury via downregulation of endoplasmic reticulum stress. [PDF]

PLoS ONE, 2013
Cardiomyocyte apoptosis is a common pathological alteration in heart disease which results in systolic dysfunction or sudden death. Klotho is a novel anti-aging hormone.
Shuang Song, Pan Gao, Hang Xiao, Yan Xu, Liang Yi Si   +4 more
doaj   +1 more source

Cardioprotective effects of compound ALM-802 on subendocardial ischemia models

Фармакокинетика и Фармакодинамика, 2021
The investigation purpose. N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine (ALM-802 compounds) cardioprotective effect has been studied in rat models of subendocardial ischemia caused by isoproterenol and ...
I. B. Tsorin, V. V. Barchukov, M. B. Vititnova, A. M. Likhosherstov, G. V. Mokrov, S. A. Kryzhanovskii   +5 more
doaj   +1 more source

Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. [PDF]

PLoS ONE, 2015
This study evaluated the chronotropic and inotropic responses to glucagon in spontaneously beating isolated right atria of rat heart. For comparison, we also investigated the effects resulting from stimulating β-adrenoceptors with isoproterenol in this ...
Beatriz Merino, Ivan Quesada, Jesús Hernández-Cascales   +2 more
doaj   +1 more source

Effects of Isoproterenol and Melatonin Supplementation on In vitro Development of Parthenogenetic Activated Oocytes in Pig

Journal of Animal Reproduction and Biotechnology, 2016
In this study, to improve the in vitro development of various cells including cloned embryos, the effects that isoproterenol and melatonin have on in vitro development of porcine parthenogenetic oocytes were investigated.
Da-Un Jeong, Yun-Jin Yun, Hee-Sung Park
doaj   +1 more source

Transcriptional changes during isoproterenol-induced cardiac fibrosis in mice

Frontiers in Molecular Biosciences, 2023
Introduction: β-adrenergic stimulation using β-agonists such as isoproterenol has been routinely used to induce cardiac fibrosis in experimental animal models.
Disha Nanda, Disha Nanda, Priyanka Pant, Priyanka Pant, Pratheusa Machha, Pratheusa Machha, Divya Tej Sowpati, Divya Tej Sowpati, Regalla Kumarswamy, Regalla Kumarswamy   +9 more
doaj   +1 more source

Arrhythmia induction using isoproterenol or epinephrine during electrophysiology study for supraventricular tachycardia [PDF]

, 2018
Background Electrophysiology study (EPS) is an important part of the diagnosis and workup for supraventricular tachycardia (SVT). Provocative medications are used to induce arrhythmias, when they are not inducible at baseline. The most common medication
Padanilam, Benzy J., Patel, Jyoti Kandlikar, Patel, Parin J., Prystowsky, Eric N., Segar, Rachel   +4 more
core   +1 more source

Low-dose l-isoproterenol versus salbutamol in hospitalized pediatric patients with severe acute exacerbation of asthma: A double-blind, randomized controlled trial

Allergology International, 2019
Background: Although the guidelines in most countries do not recommend continuous inhalation of l-isoproterenol to treat pediatric patients with acute severe exacerbation of asthma, lower dose of l-isoproterenol has been widely used in Japan.
Toshio Katsunuma, Takao Fujisawa, Takanobu Maekawa, Kenichi Akashi, Yukihiro Ohya, Yuichi Adachi, Koji Hashimoto, Mihoko Mizuno, Takanori Imai, Mari S. Oba, Mayumi Sako, Yasuo Ohashi, Hidefumi Nakamura   +12 more
doaj   +1 more source

The conventional isoproterenol-induced heart failure model does not consistently mimic the diaphragmatic dysfunction observed in patients.

PLoS ONE, 2020
Heart failure (HF) impairs diaphragm function. Animal models realistically mimicking HF should feature both the cardiac alterations and the diaphragmatic dysfunction characterizing this disease.
Ignacio Cabrera-Aguilera, Bryan Falcones, Alicia Calvo-Fernández, Begoña Benito, Esther Barreiro, Joaquim Gea, Ramon Farré, Isaac Almendros, Núria Farré   +8 more
doaj   +1 more source