Results 1 to 10 of about 89,475 (303)

Cardiac Gene Therapy With Phosphodiesterase 2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure. [PDF]

J Am Heart Assoc
Background PDE2 (phosphodiesterase 2) is upregulated in human heart failure. Cardiac PDE2‐transgenic mice are protected against contractile dysfunction and arrhythmias in heart failure but whether an acute elevation of PDE2 could be of therapeutic value ...
Kamel R, Bourcier A, Margaria JP, Jin V, Varin A, Hivonnait A, Mercier-Nomé F, Mika D, Ghigo A, Charpentier F, Algalarrondo V, Hirsch E, Fischmeister R, Vandecasteele G, Leroy J.   +14 more
europepmc   +2 more sources

Generation and escape of local waves from the boundary of uncoupled cardiac tissue [PDF]

, 2007
We aim to understand the formation of abnormal waves of activity from myocardial regions with diminished cell-to-cell coupling. In route to this goal, we studied the behavior of a heterogeneous myocyte network in which a sharp coupling gradient was ...
Agladze, Ara Arutunyan, Arutunyan, Arutunyan, Arutunyan, Beeler, Bers, Bogdanov, Bub, Carmeliet, Dhamoon, Dhein, Elizari, Entcheva, Entcheva, Entcheva, Iravanian, Karmazyn, Keener, Kies, Kleber, Lakkireddy, Lameris, Laurita, Masuda, Mills, Narine A. Sarvazyan, Pertsov, Peters, Peters, Pumir, Pumir, Rubart, Schlotthauer, Shen, Silva, Stevenson, Ter Keurs, Vadim N. Biktashev, Wahler, Warner, White, Yamada, Zipes   +43 more
core   +4 more sources

Senescence-like Phenotype After Chronic Exposure to Isoproterenol in Primary Quiescent Immune Cells. [PDF]

Biomolecules
Chronic stress is associated with a higher risk for carcinogenesis as well as age-related diseases and immune dysfunction. There is evidence showing that psychological stress can contribute to premature immunosenescence.
Laumann M, Palombo P, Fieres J, Thomas M, Saretzki G, Bürkle A, Moreno-Villanueva M.   +6 more
europepmc   +2 more sources

Transient conduction block of the superior vena cava following pulsed field ablation of the right superior pulmonary vein. [PDF]

J Arrhythm
This case demonstrates that an immediate superior vena cava (SVC) conduction block may occur during pulsed field ablation (PFA) due to anatomical proximity, a positive tissue proximity index, and a narrow SVC diameter. However, lesions not directly influenced by PFA tend to regress and may be reversible, leading to SVC potential reconduction.
Takahashi K, Makita T, Shimoshige S, Kuwahara T.   +3 more
europepmc   +2 more sources

Effects of Intrauterine Isoproterenol Administration on Ovarian Follicular Development in Cows. [PDF]

Vet Med Sci
Background Isoproterenol (ISO) is a nonselective beta‐adrenergic receptor agonist known for its vasodilatory effects. This experiment aims to investigate whether intrauterine ISO administration could alter vascular indices and follicular development in ...
Tohumcu V, Cengiz M, Hayirli A, Altinkaynak K, Arslanbas E, Ciplak AY, Aydın S, Alat O.   +7 more
europepmc   +2 more sources

Exposure to Doxorubicin Modulates the Cardiac Response to Isoproterenol in Male and Female Mice

Pharmaceuticals, 2023
Sex is a salient risk factor in the development of doxorubicin-induced cardiotoxicity. Sex differences in the heart’s ability to respond to hypertrophic stimuli in doxorubicin-exposed animals have not been reported.
Kevin Agostinucci, Marianne K. O. Grant, Wongel Melaku, Chandini Nair, Beshay N. Zordoky   +4 more
doaj   +1 more source

Klotho suppresses cardiomyocyte apoptosis in mice with stress-induced cardiac injury via downregulation of endoplasmic reticulum stress. [PDF]

PLoS ONE, 2013
Cardiomyocyte apoptosis is a common pathological alteration in heart disease which results in systolic dysfunction or sudden death. Klotho is a novel anti-aging hormone.
Shuang Song, Pan Gao, Hang Xiao, Yan Xu, Liang Yi Si   +4 more
doaj   +1 more source

Cardioprotective effects of compound ALM-802 on subendocardial ischemia models

Фармакокинетика и Фармакодинамика, 2021
The investigation purpose. N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine (ALM-802 compounds) cardioprotective effect has been studied in rat models of subendocardial ischemia caused by isoproterenol and ...
I. B. Tsorin, V. V. Barchukov, M. B. Vititnova, A. M. Likhosherstov, G. V. Mokrov, S. A. Kryzhanovskii   +5 more
doaj   +1 more source

Cardiac-directed expression of a catalytically inactive adenylyl cyclase 6 protects the heart from sustained β-adrenergic stimulation. [PDF]

, 2017
ObjectivesIncreased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and cAMP-independent pathways.
Gao, Mei Hua, Giamouridis, Dimosthenis, Guo, Tracy, Hammond, H Kirk, Kim, Young Chul, Lai, N Chin   +5 more
core   +6 more sources

Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. [PDF]

PLoS ONE, 2015
This study evaluated the chronotropic and inotropic responses to glucagon in spontaneously beating isolated right atria of rat heart. For comparison, we also investigated the effects resulting from stimulating β-adrenoceptors with isoproterenol in this ...
Beatriz Merino, Ivan Quesada, Jesús Hernández-Cascales   +2 more
doaj   +1 more source