Results 1 to 10 of about 91,861 (319)
Lack of sexual dimorphism in a mouse model of isoproterenol-induced cardiac dysfunction.
PLoS ONE, 2020 Sex-related differences in cardiovascular diseases are highly complex in humans and model-dependent in experimental laboratory animals. The objective of this work was to comprehensively investigate key sex differences in the response to acute and ...
Marianne K O Grant +4 more
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Evaluation of Antioxidant and Immunity Activities of Quercetin in Isoproterenol-Treated Rats
Molecules, 2012 The present study was designed to evaluate the effect of quercetin on myocardial oxidative stress and immunity function impairment induced by isoproterenol in rats.
Shaoping Lu, Lei Zhang, Hui Liu
doaj +2 more sources
Cardiac Gene Therapy With Phosphodiesterase 2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground PDE2 (phosphodiesterase 2) is upregulated in human heart failure. Cardiac PDE2‐transgenic mice are protected against contractile dysfunction and arrhythmias in heart failure but whether an acute elevation of PDE2 could be of therapeutic value ...
Rima Kamel +14 more
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BMC Cardiovascular Disorders, 2011 Background Cardiomyopathy in Duchenne muscular dystrophy (DMD) is an increasing cause of death in patients. The absence of dystrophin leads to loss of membrane integrity, cell death and fibrosis in cardiac muscle.
Sali Arpana +6 more
doaj +2 more sources
Frontiers in Pharmacology, 2021 Histone deacetylase (HDAC) expression and enzymatic activity are dysregulated in cardiovascular diseases. Among Class I HDACs, HDAC2 has been reported to play a key role in cardiac hypertrophy; however, the exact function of HDAC8 remains unknown.
Tingwei Zhao +5 more
semanticscholar +1 more source
Exposure to Doxorubicin Modulates the Cardiac Response to Isoproterenol in Male and Female Mice
Pharmaceuticals, 2023 Sex is a salient risk factor in the development of doxorubicin-induced cardiotoxicity. Sex differences in the heart’s ability to respond to hypertrophic stimuli in doxorubicin-exposed animals have not been reported.
Kevin Agostinucci +4 more
doaj +1 more source
The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist [PDF]
, 2013 Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the ...
Andresen, Bradley T. +9 more
core +10 more sources
Klotho suppresses cardiomyocyte apoptosis in mice with stress-induced cardiac injury via downregulation of endoplasmic reticulum stress. [PDF]
PLoS ONE, 2013 Cardiomyocyte apoptosis is a common pathological alteration in heart disease which results in systolic dysfunction or sudden death. Klotho is a novel anti-aging hormone.
Shuang Song +4 more
doaj +1 more source