Results 21 to 30 of about 29,381 (199)

A Possible Novel Protective Effect of Piceatannol against Isoproterenol (ISO)-Induced Histopathological, Histochemical, and Immunohistochemical Changes in Male Wistar Rats

Current Issues in Molecular Biology, 2022
Dry mouth is characterized by lower saliva production and changes in saliva composition. In patients with some salivary gland function remaining, pharmaceutical treatments are not recommended; therefore, new, more effective methods of promoting saliva ...
Samar A. Alghamdi, Maryam H. Mugri, Nahid M. H. Elamin, Mona Awad Kamil, Hind Osman, Basma G. Eid, Rasheed A. Shaik, Soad S. Shaker, Aziza Alrafiah   +8 more
doaj   +1 more source

Impairment of β-adrenergic regulation and exacerbation of pressure-induced heart failure in mice with mutations in phosphoregulatory sites in the cardiac CaV1.2 calcium channel

Frontiers in Physiology, 2023
The cardiac calcium channel CaV1.2 conducts L-type calcium currents that initiate excitation-contraction coupling and serves as a crucial mediator of β-adrenergic regulation of the heart.
Liam Hovey, Liam Hovey, Xiaoyun Guo, Yi Chen, Qinghang Liu, William A. Catterall   +5 more
doaj   +1 more source

Pengaruh Ramipril terhadap Gambaran Mikroskopis Sel Neuron Otak Tikus Wistar yang Mengalami Edema Otak

Jurnal Ilmu Kesehatan Indonesia, 2022
Background. Brain edema is swelling in the brain due to excessive accumulation of fluid in the brain. This condition is triggered by a decrease in cerebral blood flow (CBF) due to heart damage or isoproterenol administraion.
Muhammad Arief Ansyar, Nita Afriani, Aisyah Ellyanti   +2 more
doaj   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Sulfated polysaccharides of Turbinaria conoides dose-dependently mitigate oxidative stress by ameliorating antioxidants in isoproterenol induced myocardial injured rats: Evidence from histopathological study

The Egyptian Heart Journal, 2012
Objectives: In recent years, fucoidan is being marketed as a nutraceutical and food supplement because of its various pharmacological activity.
Krishnamoorthy Mohankumar, Selvaraju Meenakshi, Thangavel Balasubramanian, Tamilarasan Manivasagam   +3 more
doaj   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Juglone from Walnut Produces Cardioprotective Effects against Isoproterenol-Induced Myocardial Injury in SD Rats

Current Issues in Molecular Biology, 2022
Therapeutic and/or preventive interventions using phytochemical constituents for ischemic heart disease have gained considerable attention worldwide, mainly due to their antioxidant activity.
Taseer Ahmad, Taous Khan, Tahira Tabassum, Yahya S. Alqahtani, Mater H. Mahnashi, Bandar A. Alyami, Ali O. Alqarni, Mohammed Y. Alasmary, Sultan A. Almedhesh, Abdul Jabbar Shah   +9 more
doaj   +1 more source

Developmentally Inspired Bioprinting of Nascent Multicellular Human Heart Tissue Through in Situ Differentiation and Morphogenesis of iPSCs

Advanced Science, EarlyView.
A developmentally inspired bioprinting approach enables the fabrication of pluripotent tissues that undergo shape‐morphing and in situ cardiac lineage specification. This method employs embedded bioprinting to deposit iPSCs within soft granular hydrogels to create pluripotent tissue constructs that undergo cell‐mediated shape morphogenesis.
Ankita Pramanick, Juhi Chakraborty, Orlaith Kennedy, Hey Wei Wong, Sogol Kianersi, Daniel Kelly, Vasileios Sergis, Abhay Pandit, Andrew C. Daly   +8 more
wiley   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

A Comparative Study of Rat Urine ¹H-NMR Metabolome Changes Presumably Arising from Isoproterenol-Induced Heart Necrosis Versus Clarithromycin-Induced QT Interval Prolongation

Biology, 2020
Cardiotoxicity remains a challenging concern both in drug development and in the management of various clinical situations. There are a lot of examples of drugs withdrawn from the market or stopped during clinical trials due to unpredicted cardiac ...
Matthieu Dallons, Manon Delcourt, Corentin Schepkens, Manuel Podrecca, Jean-Marie Colet   +4 more
doaj   +1 more source