Results 51 to 60 of about 56,897 (225)
Advanced Science, EarlyView.The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu +10 more
wiley +1 more source
Cardioprotective effect of Resveratrol on Isoproterenol-induced experimental myocardial infarction in rat [PDF]
Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, 2014 Myocardial infarction affecting the mechanical, electrical, structural and biochemical properties of the heart, accounts for one of the causes of death in developed countries. The aim of this study was to evaluate the protective effects of resveratrol on
daryoush mohajeri +3 more
doaj
In preeclampsia, maternal third trimester subcutaneous adipocyte lipolysis is more resistant to suppression by insulin than in healthy pregnancy [PDF]
, 2014 Obesity increases preeclampsia risk, and maternal dyslipidemia may result from exaggerated adipocyte lipolysis. We compared adipocyte function in preeclampsia with healthy pregnancy to establish whether there is increased lipolysis.
Forrest, Rachel. +5 more
core +1 more source
Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk
Advanced Science, EarlyView.Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu +10 more
wiley +1 more source
Gel‐Amin for Improving Extracellular Recordings of Cardiomyocytes in a 3D Microphysiological System
Advanced Electronic Materials, EarlyView.This work combines a conductive collagen‐based hydrogel with a laser‐cut and assembly technique to fabricate microphysiological systems that improve extracellular recordings of cardiomyocytes in 3D on microelectrode arrays. The inclusion of choline acrylate into GelMA imparts a higher electrical conductivity and improves the signal‐to‐noise ratio of on‐
Dominic Pizzarella +4 more
wiley +1 more source
Zinc and water intake in rats: investigation of adrenergic and opiatergic central mechanisms
Brazilian Journal of Medical and Biological Research, 1999 We have demonstrated that central administration of zinc in minute amounts induces a significant antidipsogenic action in dehydrated rats as well as in rats under central cholinergic and angiotensinergic stimulation.
J.B. Fregoneze +12 more
doaj +1 more source
Protein kinase A (PKA) phosphorylation of Shp2 inhibits its phosphatase activity and modulates ligand specificity. [PDF]
, 2015 Pathological cardiac hypertrophy (an increase in cardiac mass resulting from stress-induced cardiac myocyte growth) is a major factor underlying heart failure.
Burmeister, BT +5 more
core +1 more source
Advanced NanoBiomed Research, EarlyView.A 3D adipose tissue model is fabricated by combining melt electrowritten scaffolds with multicellular adipose‐derived stromal cell spheroids. The resulting constructs are characterized by a coherent, tissue‐like matrix. The lipid droplet size is tunable by oleic acid supplementation, reaching native‐like diameters.
Franziska Dusi +10 more
wiley +1 more source
The beneficial effects of ivabradine against myocardial damage induced by isoproterenol in rats
Medicine Science, 2023 We aimed to investigate the potential benefits of two doses of ivabradine (IVA)-an If sodium channel blocker against isoproterenol (ISO)-induced myocardial damage in rats.The rats were randomly divided into 4 groups: Control group (n=8); Saline was ...
Seyhan Polat +10 more
doaj +1 more source
The adenylate cyclase receptor complex and aqueous humor formation. [PDF]
, 1984 The secretory tissue of the eye, the ciliary processes, contains an enzyme receptor complex, composed of membrane proteins, the catalytic moiety of the enzyme adenylate cyclase, a guanyl nucleotide regulatory protein (or N protein), and other features ...
Caprioli, J, Sears, M
core +1 more source