Results 71 to 80 of about 89,475 (303)

Current and novel biomarkers in cardiogenic shock

European Journal of Heart Failure, EarlyView.
A summary of current and novel biomarkers and their potential stages of release in cardiogenic shock. The diagram illustrates the proposed release of the biomarkers during the different stages of cardiogenic shock: progression from cardiac dysfunction/stress, through to inflammation and end‐organ dysfunction.
Victor Galusko, Florian A. Wenzl, Christophe Vandenbriele, Vasileios Panoulas, Thomas F. Lüscher, Diana A. Gorog   +5 more
wiley   +1 more source

β2-adrenergic agonists modulate TNF-α induced astrocytic inflammatory gene expression and brain inflammatory cell populations [PDF]

, 2014
Background: The NF-kappa B signaling pathway orchestrates many of the intricate aspects of neuroinflammation. Astrocytic beta(2)-adrenergic receptors have emerged as potential regulators in central nervous system inflammation and are potential targets ...
Aerts, Joeri L, De Keyser, Jacques, Demol, Frauke, Gerlo, Sarah, Laureys, Guy, Spooren, Anneleen   +5 more
core   +3 more sources

Exploring the Potential of Liposomal Delivery of Naringenin and Berberine for Browning Adipose Tissue and Obesity Management

European Journal of Lipid Science and Technology, EarlyView.
Biocompatible and biodegradable liposomes were developed to encapsulate naringenin (N) and berberine (B), enhancing their stability and bioavailability. Their effects on thermogenesis and browning in 3T3‐L1 preadipocyte cells compared to their free forms were investigated.
Elif Didem Örs Demet, Kübra Uçar Baş, Aslıhan Alpaslan, Dilem Tuğal Aslan, Tuba Reçber, Tuğba Gülsün, Mustafa Çelebier, Zeynep Göktaş   +7 more
wiley   +1 more source

Rapamycin Attenuated Cardiac Hypertrophy Induced by Isoproterenol and Maintained Energy Homeostasis via Inhibiting NF-κB Activation

Mediators of Inflammation, 2014
Rapamycin, also known as sirolimus, is an immunosuppressant drug used to prevent rejection organ (especially kidney) transplantation. However, little is known about the role of Rapa in cardiac hypertrophy induced by isoproterenol and its underlying ...
X. Chen, Siyu Zeng, J. Zou, Yanfang Chen, Z. Yue, Ying Gao, Luankun Zhang, Weiwei Cao, Peiqing Liu   +8 more
semanticscholar   +1 more source

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

Transcriptional changes during isoproterenol-induced cardiac fibrosis in mice

Frontiers in Molecular Biosciences, 2023
Introduction: β-adrenergic stimulation using β-agonists such as isoproterenol has been routinely used to induce cardiac fibrosis in experimental animal models.
Disha Nanda, Disha Nanda, Priyanka Pant, Priyanka Pant, Pratheusa Machha, Pratheusa Machha, Divya Tej Sowpati, Divya Tej Sowpati, Regalla Kumarswamy, Regalla Kumarswamy   +9 more
doaj   +1 more source

The TissueTractor: A Device for Applying Large Strains to Tissues and Cells for Simultaneous High‐Resolution Live Cell Microscopy

Small Methods, EarlyView.
Mechanical strain influences tissue development, homeostasis, and disease. The TissueTractor, a high‐strain stretcher system, enables high‐resolution imaging of live tissues and cells under strain, revealing cellular strain heterogeneity, cytoskeletal remodeling, and morphological adaptations in various model systems.
Jing Yang, Emily Hearty, Yingli Wang, Deepthi S. Vijayraghavan, Timothy Walter, Sommer Anjum, Carsten Stuckenholz, Ya‐Wen Cheng, Sahana Balasubramanian, Yicheng Dong, Adam V. Kwiatkowski, Lance A. Davidson   +11 more
wiley   +1 more source

The adenylate cyclase receptor complex and aqueous humor formation. [PDF]

, 1984
The secretory tissue of the eye, the ciliary processes, contains an enzyme receptor complex, composed of membrane proteins, the catalytic moiety of the enzyme adenylate cyclase, a guanyl nucleotide regulatory protein (or N protein), and other features ...
Caprioli, J, Sears, M
core   +1 more source

Characterization and differentiation of myocardial remodeling using artificial intelligence‐assisted confocal Raman spectroscopy imaging

VIEW, EarlyView.
Myocardial remodeling is a key factor in heart failure. Rats were treated with ISO to induce remodeling, confirmed by echocardiography and staining. Confocal Raman spectroscopy imaging provided detailed insights into tissue architecture and the differentiation of regions.
Renxing Song, Xunyi Yin, Manlin Zhu, Xinyu Chen, Zhen Zhang, Xiaoming Lyu, Shuang Jiang, Zhehan Liu, Yuting Li, Zhaoying Zhang, Tao Ban, Yang Li   +11 more
wiley   +1 more source

Advancing antihypertensive drug development

British Journal of Pharmacology, EarlyView.
Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu, Yanrong Liu, Fozia Zahir Ahmed, Xin Wang, Darren Green, Hongyuan Zhang   +5 more
wiley   +1 more source