Results 81 to 90 of about 89,475 (303)
Journal of Advanced Pharmaceutical Technology & Research, 2013 Saussurea lappa Clarke (Compositae), is commonly known as Kushta. In Ayurvedha, it is mentioned that the aqueous extract of the root S. lappa was used for treatment of angina pectoris.
TS Mohamed Saleem +5 more
semanticscholar +1 more source
Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of G(i)- and G(q)-mediated signaling [PDF]
, 1999 RGS proteins (Regulators of G protein Signaling) are a recently discovered family of proteins that accelerate the GTPase activity of heterotrimeric G protein α subunits of the i, q, and 12 classes.
Backlund, Peter S. +5 more
core +1 more source
A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains
The FEBS Journal, EarlyView.Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley +1 more source
Revista Colombiana de Cardiología, 2006 Introducción: el isoproterenol es el fármaco que se ha empleado tradicionalmente para incrementar la inducción de arritmias cuando durante la estimulación eléctrica programada del corazón en condiciones basales, no se logra su inducción. La dobutamina es
Diego I Vanegas +3 more
doaj
Time-dependent responses of rat troponin I and cardiac injury following isoproterenol administration [PDF]
Medicinski Glasnik, 2011 Aim To develop a rat model of myocardial infarction induced by isoproterenol (ISO). We investigated a type of histological myocardial changes and cardiac troponin I (TnI) kinetic. Methods The study has used adult, male, Wistar strain rats.
Sabaheta Hasić +5 more
doaj
PLoS ONE, 2012 Background Traditional Chinese medicinal herbs Cortex Moutan and Radix Salviae Milthiorrhizaeare are prescribed together for their putative cardioprotective effects in clinical practice. However, the rationale of the combined use remains unclear.
Hua Li +12 more
semanticscholar +1 more source
A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart. [PDF]
, 2017 Phospholamban (PLN) is a key regulator of sarcolemma calcium uptake in cardiomyocyte, its inhibitory activity to SERCA is regulated by phosphorylation. PLN hypophosphorylation is a common molecular feature in failing heart.
Akaike, Toru +5 more
core +1 more source
The FEBS Journal, EarlyView.In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman +13 more
wiley +1 more source
Conjugated linoleic acid and betaine affect lipolysis in pig adipose tissue explants
Animal, 2019 Consumers’ demand of leaner meat products is a challenge. Although betaine and conjugated linoleic acid (CLA) have the potential to decrease porcine adipose tissue, their mode of action is poorly understood.
I. Fernández-Fígares +3 more
doaj
General Physiology and Biophysics, 2012 The animal models of myocardial injury induced by systemic β-adrenergic receptor agonist administration represent an experimental approach of persisting interest.
Zuzana Nichtová +3 more
semanticscholar +1 more source