Results 121 to 130 of about 6,842 (226)

Synthesis of substituted isoquinolines utilizing palladium-catalyzed α-arylation of ketones.

, 2012
The utilization of sequential palladium-catalyzed α-arylation and cyclization reactions provides a general approach to an array of isoquinolines and their corresponding N-oxides.
Pilgrim, BS, Bassuto, JA, Donohoe, Timothy, Donohoe, TJ, Jones, GR   +4 more
core   +1 more source

Palladium-catalysed enolate arylation in the synthesis of isoquinolines

, 2014
Chapter 1. Introduction Scientific background on the development of homogeneous palladium-catalysed cross coupling reactions, focusing on the α-arylation reaction of enolates and its application to the synthesis of heteroaromatic compounds.
Donohoe, Timothy J., Gatland, Alice Elizabeth   +1 more
core   +3 more sources

Guanine-functionalized MWCNT-supported Cu(I) magnetic nanocatalyst for green synthesis of isoquinolines in PEG/H₂O

Journal of Saudi Chemical Society
This study reports the development of a guanine-functionalized, multi-walled carbon nanotube (MWCNT)–supported copper(I) magnetic nanocatalyst designed to enable a rapid, green, three-component synthesis of isoquinolines.
Enas Daoud, Hussam Al-Din Haitham Kareem, Amina Dawood Suleman, Praharshkumar B. Raj, Subbulakshmi Ganesan, C. P. Surya, Lalita Chopra, Reza Mohammadi   +7 more
doaj   +1 more source

Novel dual kappa/mu opioid ligands based on a tetrahydroisoquinoline-valine hybrid nucleus

Scientific Reports
Opioid addiction constitutes a significant global health challenge. Kappa opioid receptor (KOP) modulators have demonstrated efficacy in treating resistant drug abuse cases.
Ahmad Abdelwaly, Hesham Safwan, Shamba Chatterjee, Mohamed Elsayed, Khaled M. Darwish, Amar Chittiboyina, Mohamed A. Helal   +6 more
doaj   +1 more source

Bromination of Pyrrolo[2,1‑a]isoquinolines with Acetyl Bromide and Dimethyl Sulfoxide

A mild bromination of pyrrolo­[2,1-a]­isoquinolines has been achieved using acetyl bromide and dimethyl sulfoxide. A series of brominated pyrrolo­[2,1-a]­isoquinolines could be obtained in moderate to excellent yields (46–99%) at room temperature.
Hai-Lei Cui (2142391)
core   +1 more source

AcBr/DMSO Mediated Sulfenylation of Pyrrolo[2,1‑a]isoquinolines

We have developed a mild sulfenylation of pyrrolo­[2,1-a]­isoquinolines with acetyl bromide and dimethyl sulfoxide. A wide range of functionalized pyrrolo­[2,1-a]­isoquinolines could be prepared efficiently through the formation of a C–S bond with ...
Xiao-Hui Chen (543865), Hai-Lei Cui (2142391)   +1 more
core   +1 more source

Copper-catalyzed one-pot synthesis of isoquinolines <i>via</i> oxidative α-amination under mild and sustainable conditions. [PDF]

RSC Adv
Akbari A, Hoseinshahi DZ.
europepmc   +1 more source

Summary of Research: Ensifentrine, a Novel Phosphodiesterase 3 and 4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease: Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase III Trials (the ENHANCE Trials). [PDF]

Adv Ther
Anzueto A, Barjaktarevic IZ, Siler TM, Rheault T, Rickard K, O'Donovan K, Sciurba F.   +6 more
europepmc   +1 more source

Greener alternatives for synthesis of isoquinoline and its derivatives: a comparative review of eco-compatible synthetic routes. [PDF]

RSC Adv
Kirad S, Deepa PR, Sankaranarayanan M.
europepmc   +1 more source

Rh(III)-Catalyzed Atroposelective C–H Selenylation of 1‑Aryl Isoquinolines

Rhodium(III)-catalyzed atroposelective C–H selenylation of 1-aryl isoquinolines has been achieved. The direct C–H selenylation reaction between 1-aryl isoquinolines and 2-(phenylselanyl)isoindoline-1,3-dione in the presence of the chiral SCpRh(III ...
Fangnuo Zhao (12550097), Dong-Song Zheng (6064982), Pei-Pei Xie (6519893), Chao Zheng (728465), Qing Gu (337545), Shu-Li You (1446211)   +5 more
core   +1 more source