Results 101 to 110 of about 6,842 (226)

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

open access: yesFood Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du   +7 more
wiley   +1 more source

A new synthetic method of 1-substituted isoquinolines

open access: yes, 2006
A series of 1-substituted isoquinolines were synthesized through the nucleophilic addition reaction of Grignard reagents to isoquinolines under the activation of benzyl chloroformate and aromatization in the presence of Pd ...
Chen Guo-Ying   +2 more
core  

Interplay of ortho- with spiro-cyclisation during iminyl radical closures onto arenes and heteroarenes

open access: yesBeilstein Journal of Organic Chemistry, 2013
Sensitised photolyses of ethoxycarbonyl oximes of aromatic and heteroaromatic ketones yielded iminyl radicals, which were characterised by EPR spectroscopy.
Roy T. McBurney, John C. Walton
doaj   +1 more source

Molluscicidal activity of Hammada scoparia (Pomel) Iljin leaf extracts and the principal alkaloids isolated from them against Galba truncatula

open access: yesMemorias do Instituto Oswaldo Cruz, 2009
The molluscicidal activity of Hammada scoparia leaf extracts and the principal alkaloids isolated from them (carnegine and N-methylisosalsoline) were tested against the mollusc gastropod, Galba truncatula, the intermediate host of Fasciola hepatica in ...
R Mezghani-Jarraya   +3 more
doaj   +1 more source

Phytochemicals in MASLD: A Focused Review of Gut Microbiome‐Linked Mechanisms

open access: yesPhytotherapy Research, Volume 40, Issue 7, Page 4041-4055, July 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as a major global health burden, yet effective pharmacological options remain limited. Recent advances highlight the gut microbiome as a key modulator of liver metabolism, inflammation, and fibrosis, making it a promising therapeutic target.
Jeong In Seo, Su Min Kim, Hye Hyun Yoo
wiley   +1 more source

Synthesis of 3H‑Pyrazolo[3,4‑c]isoquinolines and Thieno[3,2‑c]isoquinolines via Cascade Imination/Intramolecular Decarboxylative Coupling

open access: yes, 2016
A general approach for the synthesis of 3H-pyrazolo[3,4-c]isoquinolines and thieno[3,2-c]isoquinolines is described involving the implementation of a cascade imination/intramolecular decarboxylative coupling between potassium 2-amino(hetero)benzoates and
Subhendu Bhowmik (1903357)   +2 more
core   +1 more source

Synthesis of Some Novel 11b-Substituted Pyrimido[6,1-a]-isoquinoline Derivatives

open access: yesMolecules, 2004
A series of novel 11b-substituted 1,6,7,11b-tetrahydropyrimido[6,1-a]- isoquinoline-2,4-diones and 4-thioxo-1,3,4,6,7,11b-hexahydropyrimido[6,1-a]isoquinolin-2- ones were synthesized, utilizing two alternative strategies for ring closure of ...
Atanas P. Venkov   +2 more
doaj   +1 more source

Antioxidants in Plant‐Based Food Matrices: From Structure–Activity and Degradation Kinetics to Formulation Design

open access: yesComprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 4, July 2026.
ABSTRACT Plant‐based antioxidants are widely incorporated into foods to retard oxidative deterioration and to deliver health‐related benefits. Yet, their in‐product and in vivo performance frequently diverges from predictions based on solution‐phase chemical assays, because matrix interactions, processing history, and host metabolism reshape both ...
Márcio Vargas‐Ramella   +6 more
wiley   +1 more source

Inositol and Berberine Synergistically Reprogram Endocrine and Ovarian Metabolism in Polycystic Ovary Syndrome

open access: yesCell Proliferation, Volume 59, Issue 7, July 2026.
In a DHEA+HFD‐induced mouse model, Ins/BBR alleviated mitochondrial defects and broadly reprogrammed metabolic landscape in granulosa cells, in specific, restoring nucleotide pools and amino acid turnover, and preventing abnormal long‐chain fatty acid accumulation.
Juan Ge   +8 more
wiley   +1 more source

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