Results 81 to 90 of about 7,156 (173)

Copper-Catalyzed C–H Functionalization of Pyridines and Isoquinolines with Vinyl Azides: Synthesis of Imidazo Heterocycles

, 2016
Copper­(I) iodide-catalyzed oxidative C­(sp2)–H functionalization of pyridines and isoquinolines for the synthesis of imidazo­[1,2-a]­pyridines and 2-phenylimidazo­[2,1-a]­isoquinolines with vinyl azides under mild aerobic conditions is reported.
Subbarayappa Adimurthy (1378134), Ramachandra Reddy Donthiri (1716925), Dipayan Bairagi (1716922), Venkatanarayana Pappula (1574815), N. Naresh Kumar Reddy (1716928)   +4 more
core   +1 more source

Anti-Inflammatory Activity of Alkaloids: An Update from 2000 to 2010

Molecules, 2011
Many natural substances with proven anti-inflammatory activity have been isolated throughout the years. The aim of this review is to review naturally sourced alkaloids with anti-inflammatory effects reported from 2000 to 2010.
Margareth de Fátima Formiga Melo Diniz, José Maria Barbosa Filho, Petrônio Filgueiras de Athayde-Filho, Marcelo Sobral da Silva, Josean Fechine Tavares, Augusto Lopes Souto   +5 more
doaj   +1 more source

SGLT2i in heart failure: Cardiorenal mechanisms, clinical evidence and translational perspectives

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
SGLT2 inhibitors improve heart failure outcomes through integrated cardiorenal mechanisms. In the kidney, they reduce glucose and sodium reabsorption, promoting natriuresis, osmotic diuresis and renal protection. In the heart, they enhance myocardial energetics, reduce inflammation, oxidative stress, fibrosis and adverse remodelling, resulting in fewer
Jelica Grujic‐Milanovic, Jovana Rajkovic, Radmila Novakovic, Javad Sharifi‐Rad, Daniela Calina   +4 more
wiley   +1 more source

Organocatalytic Enantioselective Addition of α‑Aminoalkyl Radicals to Isoquinolines

, 2018
With a dual organocatalytic system involving a chiral phosphoric acid and a dicyanopyrazine-derived chromophore (DPZ) photosensitizer and under the irradiation with visible light, an enantioselective Minisci-type addition of α-amino acid-derived redox ...
Xiangyuan Liu (668112), Guobi Chai (2053657), Xiaowei Zhao (127368), Zhiyong Jiang, Baokun Qiao, Xiaowei Zhao, Yang Liu (4829), Baokun Qiao (1528993), Xiangyuan Liu, Zhiyong Jiang (562967), Yang Liu, Guobi Chai   +11 more
core   +1 more source

Synthesis of Pyrrolo[2,1‑a]isoquinolines through Cu-Catalyzed Condensation/Addition/Oxidation/Cyclization Cascade

, 2022
We have developed a copper-catalyzed synthesis of pyrrolo[2,1-a]isoquinolines with terminal alkynes, aldehydes, and tetrahydroisoquinolines. A variety of pyrrolo[2,1-a]isoquinolines have been prepared in 17–69% yield via a condensation/Mannich-type ...
Xiao-Hui Chen (543865), Hai-Lei Cui (2142391)   +1 more
core   +1 more source

Rh(III)-Catalyzed Double Annulation of 3-Phenyl-1,2,4-oxadiazoles with 2-Diazo-1,3-diketones: Access to Pyran-Fused Isoquinolines

Molecules
Efficient access to pyranoisoquinoline derivatives via rhodium-catalyzed double C-H functionalization of phenyl oxadiazoles and diazo compounds has been developed.
Enshen Zhang, Mei Sun, Lvlv Gao
doaj   +1 more source

Phytochemical Profiling and Evaluation of Antibacterial, Anticancer, Anti‐inflammatory, and Wound‐Healing Activities of Endophytic Fungi Isolated From Atalantia racemosa

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
ABSTRACT Endophytic fungi are recognized as prolific sources of structurally diverse secondary metabolites with significant pharmaceutical potential. In the present study, endophytic fungi were isolated from healthy tissues of Atalantia racemosa (Rutaceae), an ethnomedicinal plant traditionally used for respiratory disorders and blood purification.
Sushma M, Arun Shettar, Joy Hoskeri, Vedamurthy A B   +3 more
wiley   +1 more source

An Efficient Route to Chiral N-Heterocycles Bearing C-F Stereogenic Center via Asymmetric Hydrogenation of Fluorinated Isoquinolines.

, 2013
An Efficient Route to Chiral N-Heterocycles Bearing C-F Stereogenic Center via Asymmetric Hydrogenation of Fluorinated ...
时磊, 蔡先锋, 叶智识, 陈木旺, 郭冉柠, 周永贵   +5 more
core  

Photochemical synthesis of benz[h]isoquinolines

, 2008
The synthesis of benz[h]isoquinolines has been achieved using a highly convergent photochemical method. The approach presented provides ready access to biologically active compounds and building blocks not readily available through other ...
Barnes, J.C., Harnor, S.J., Abbott, B.M., Marquez, R., Ferrari, F.D.   +4 more
core   +1 more source

Suzuki Cross-Coupling/Reductive Debenzyloxycarbonylation Sequence for the Syntheses of [c]Annulated Isoquinolines: Application for the Syntheses of Pancratistatin-like Isoquinolines

, 2016
A two-step strategy involving Suzuki cross-coupling of boronic acids with a diverse array of α-iodoenones followed by hydrogenation is developed for the construction of [c]annulated isoquinolines.
Madhesan Balakrishnan (2413840), Ganesh Pandey (1520503)   +1 more
core   +1 more source