Results 81 to 90 of about 6,842 (226)

Organocatalytic Enantioselective Addition of α‑Aminoalkyl Radicals to Isoquinolines

, 2018
With a dual organocatalytic system involving a chiral phosphoric acid and a dicyanopyrazine-derived chromophore (DPZ) photosensitizer and under the irradiation with visible light, an enantioselective Minisci-type addition of α-amino acid-derived redox ...
Xiangyuan Liu (668112), Guobi Chai (2053657), Xiaowei Zhao (127368), Zhiyong Jiang, Baokun Qiao, Xiaowei Zhao, Yang Liu (4829), Baokun Qiao (1528993), Xiangyuan Liu, Zhiyong Jiang (562967), Yang Liu, Guobi Chai   +11 more
core   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Anti-Inflammatory Activity of Alkaloids: An Update from 2000 to 2010

Molecules, 2011
Many natural substances with proven anti-inflammatory activity have been isolated throughout the years. The aim of this review is to review naturally sourced alkaloids with anti-inflammatory effects reported from 2000 to 2010.
Margareth de Fátima Formiga Melo Diniz, José Maria Barbosa Filho, Petrônio Filgueiras de Athayde-Filho, Marcelo Sobral da Silva, Josean Fechine Tavares, Augusto Lopes Souto   +5 more
doaj   +1 more source

Transcriptional Regulation of the Novel Theacrine Synthase Gene CsTcS2 by the CsTINY–CsWRKY33 Module Underpins Theacrine Biosynthesis in Camellia sinensis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Theacrine (1,3,7,9‐tetramethyluric acid) is a purine alkaloid detected in multiple wild and specialised tea germplasms (Camellia sinensis) from South China, including Kucha. However, the molecular mechanisms governing its biosynthesis remain poorly understood. Here, we identify CsTcS2 as a novel theacrine synthase in tea plant.
Ting Wu, Lihua Zhu, Chenyu Shao, Siyi Xie, Na Li, Xinyu Li, Fang Wang, Lvwen Peng, Huiying Jin, Fanghuizi Shang, Jianan Huang, Zhonghua Liu, Na Tian, Shuoqian Liu   +13 more
wiley   +1 more source

Cell‐Specific Expression and Cellular Compartmental Regulation in Camptothecin Biosynthesis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant secondary metabolites such as monoterpenoid indole alkaloids (MIAs) show tightly regulated biosynthesis and accumulation in specific organelles of distinct cell types. However, the cell‐specific expression patterns of anticancer MIA camptothecin biosynthetic genes in Ophiorrhiza pumila and the regulatory mechanisms of camptothecin ...
Xiaolong Hao, Yinkai Yang, Tiantian Chen, Xiaoxuan Fan, Yiqing Peng, Qingyan Ruan, Qin Zhou, Fanghao Liu, Jiayi He, Yongpeng Li, Yue Feng, Jiyan Qi, Guoyin Kai   +12 more
wiley   +1 more source

Insights Into the Origin and Local Adaptation Evolution of the Cultivated Sesame With Telomere‐to‐Telomere High‐Quality Genome

Plant Biotechnology Journal, EarlyView.
ABSTRACT Sesame (Sesamum indicum L., 2n = 26) is one of the oldest oilseed crops and is often called the ‘queen of oilseeds’ due to its high content of unsaturated fatty acids and natural antioxidants. Despite its long history, the origin and global spread of cultivated sesame remain unresolved.
Weifei Yang, Hengchun Cao, Hui Guo, Hongmei Miao, Guiting Li, Yinghui Duan, Ming Ju, Qiuzhen Tian, Qin Ma, Pengjie Chang, Zhanyou Zhang, Cong Mu, Xiaoxu Feng, Libin Wei, Weixiu Hou, Andrew H. Paterson, Haiyang Zhang   +16 more
wiley   +1 more source

Photochemical synthesis of benz[h]isoquinolines

, 2008
The synthesis of benz[h]isoquinolines has been achieved using a highly convergent photochemical method. The approach presented provides ready access to biologically active compounds and building blocks not readily available through other ...
Barnes, J.C., Harnor, S.J., Abbott, B.M., Marquez, R., Ferrari, F.D.   +4 more
core   +1 more source

Base-Promoted Synthesis of Isoquinolines through a Tandem Reaction of 2‑Methyl-arylaldehydes and Nitriles

A convenient method for preparing 3-aryl isoquinolines via a base-promoted tandem reaction is presented. Simply combining commercially available 2-methyl-arylaldehydes, benzonitriles, NaN(SiMe3)2, and Cs2CO3 enabled the synthesis of a variety of ...
Sujuan Shuai (18475643), Jianyou Mao (1426300), Patrick J. Walsh (304213), Fan Zhou (196667), Lingfeng Chen (153537), Qifeng Yan (11430037), Jie Li (15030), Guang Liang (206236)   +7 more
core   +2 more sources

Colon‐Targeted Berberine Nanoparticles‐Embedded Yeast Microcapsules for Regulation of Gut Immunity of Sepsis

eFood, Volume 7, Issue 4, August 2026.
A schematic representation illustrating the preparation of BGNP@YM and its therapeutic effects on septic mice induced by lipopolysaccharide (LPS). (A) BBR is first encapsulated within GNPs to form BGNPs with anti‐inflammatory activity, which are subsequently coated with YM via chemical precipitation to obtain the BGNP@YM oral delivery system.
Qing‐Qing Dong, Si‐Hui Wang, Chen‐Yan Wang, Ke‐Da Yang, Xiao‐Ling Xu, Yi Shi, Wei Chen   +6 more
wiley   +1 more source

An Efficient Route to Chiral N-Heterocycles Bearing C-F Stereogenic Center via Asymmetric Hydrogenation of Fluorinated Isoquinolines.

, 2013
An Efficient Route to Chiral N-Heterocycles Bearing C-F Stereogenic Center via Asymmetric Hydrogenation of Fluorinated ...
时磊, 蔡先锋, 叶智识, 陈木旺, 郭冉柠, 周永贵   +5 more
core