Results 91 to 100 of about 7,156 (173)
Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.Two new asperfurans (1 and 2) and 23 known compounds from marine Aspergillus flavus were characterized by NMR, HRESIMS, DP4+, and ECD. Asperfuran (3) potently inhibited RSL3‐induced ferroptosis (EC50 = 0.81 µM). ABSTRACT Marine microorganisms represent a prolific reservoir of chemically diverse natural products endowed with considerable therapeutic ...
Chun‐Xiu Wang +4 more
wiley +1 more source
A convenient method for preparing 3-aryl isoquinolines via a base-promoted tandem reaction is presented. Simply combining commercially available 2-methyl-arylaldehydes, benzonitriles, NaN(SiMe3)2, and Cs2CO3 enabled the synthesis of a variety of ...
Sujuan Shuai (18475643) +7 more
core +2 more sources
Effects of Drug Resistance on the Global Spread of Malaria: A Systematic Literature Review
Health Science Reports, Volume 9, Issue 9, September 2026.ABSTRACT Background and Aims Malaria remains a major health crisis in tropical regions, with Sub‐Saharan Africa bearing the heaviest burden. While insecticide‐treated nets and artemisinin‐based combination therapies (ACTs) have reduced cases, emerging parasite resistance to artemisinin threatens these gains. This review synthesizes evidence on how drug
Ashenafi Woldemichael Woime
wiley +1 more source
, 2016 Synthesis of pyrrolo-isoquinolines related to the lamellarin alkaloids employing silver-catalyzed cycloisomerization−dipolar cycloaddition of alkynyl N-benzylidene glycinates is described.
John A. Porco (1307085) +1 more
core +2 more sources
Molecules, 2017 The detoxification of the phytoalexin brassinin to indole-3-carboxaldehyde and S-methyl dithiocarbamate is catalyzed by brassinin oxidase (BOLm), an inducible fungal enzyme produced by the plant pathogen Leptosphaeria maculans.
M. Soledade C. Pedras +2 more
doaj +1 more source
Advances in Organic Aggregates for Biomedical Phototheranostics
MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.Organic aggregates offer aggregation‐regulated photophysical properties for biomedical phototheranostics, enabling enhanced fluorescence, stabilized room‐temperature phosphorescence, and efficient photoacoustic/photothermal responses. This review highlights molecular design strategies, excited‐state energy modulation, biomedical applications, and ...
Bowen Fu, Yayun Peng, Ting Cai
wiley +1 more source
TRANSFORMATION OF 2-BENZOYLAMINO-1-(?-NAPHTHYL)PROPAN-1-OL INTO 4-METHYL-1-PHENYL BENZO[f] ISOQUINOLINE RATHER THAN ITS 3-SUBSTITUTED ISOMER [PDF]
Journal of Sciences, Islamic Republic of Iran, 2001 The necessary conditions to transform hydroxyamide (1) and 2-oxazolines (2, 3) into 3- or 4-methyl benzo[f] isoquinolines (4, 5) has been established. The mechanism of these reactions has been proposed claiming the existence of the protonated 2-oxazoline
doaj
Avoiding pitfalls when modelling ligands in macromolecular crystallography
Acta Crystallographica Section D, Volume 82, Issue 9, Page 1016-1029, September 2026.Flawed protein–ligand X‐ray structures can misdirect drug discovery based on PDB‐deposited models. This review uses publicly available PDB examples to highlight potential pitfalls, from absent ligands to incorrect chemistry, and presents a practical validation approach to improve model reliability.The determination of protein–ligand complex structures ...
Oliver S. Smart +4 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2013 Sensitised photolyses of ethoxycarbonyl oximes of aromatic and heteroaromatic ketones yielded iminyl radicals, which were characterised by EPR spectroscopy.
Roy T. McBurney, John C. Walton
doaj +1 more source
Synthesis and Fluorescent Properties of Novel Isoquinoline Derivatives
Molecules, 2019 Isoquinoline derivatives have attracted great interest for their wide biological and fluorescent properties. In the current study, we focused on the synthesis of a series of novel isoquinoline derivatives substituted at position 3 of the heteroaromatic ...
Łukasz Balewski +5 more
doaj +1 more source