Results 111 to 120 of about 6,842 (226)

Isoquinolines from the Roots of Thalictrum flavum L. and Their Evaluation as Antiparasitic Compounds

Molecules, 2010
Alkaloids from Thalictrum flavum L. (Ranuculaceae) growing in the Loire valley (France) were isolated and evaluated for their antiplasmodial and leishmanicidal activities.
Pascal Richomme, Jacqueline Ropivia, Fabrice Pagniez, Patrice Le Pape, Séverine Derbré, Caroline Rouger   +5 more
doaj   +1 more source

Enhanced CO2 Coordinates the Spatial Recruitment of Diazotrophs in Rice Via Root Development

Plant, Cell &Environment, Volume 49, Issue 7, Page 3678-3693, July 2026.
ABSTRACT Understanding the reciprocal interaction between root development and coadapted beneficial microbes in response to elevated CO2 (eCO2) will facilitate the identification of nutrient‐efficient cultivars for sustainable agriculture. Here, systematic morphological, anatomical, chemical and gene expression assays performed under low‐nitrogen ...
Junwen Zhao, Yuting Chen, Qi Tao, Lukas Schreiber, Kiran Suresh, Michael Frei, Muhammad Shahedul Alam, Bing Li, Yaping Zhou, Marcel Baer, Frank Hochholdinger, Changquan Wang, Peng Yu   +12 more
wiley   +1 more source

1,1‐and 1,2‐Diborylalkenes: Preparation and Synthetic Applications

Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
In this review, we highlight recent advances in the synthesis and reactivity of 1,1‐diborylalkenes and 1,2‐diborylalkenes, along with various transformations leading to C‐C, C‐heteroatom, and multicomponent products. By providing a comprehensive and practical resource, this review aims to assist researchers in exploring the synthetic utility of 1,1 and
Jayaram Vankudoth, Maruti Mali, Fabienne Berrée   +2 more
wiley   +1 more source

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

Rh(III)‐Catalyzed [4+2] Annulation of Imidazoles With α‐Diazocarbonyl Compounds: Direct Access to π‐Conjugated Imidazole‐Fused Isoquinolinone

European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.
A Rh(III)‐catalyzed [4 + 2] annulation of 2‐aryl imidazoles/benzimidazoles with α‐diazocarbonyl compounds is developed for the synthesis of π‐conjugated imidazo/benzimidazo[2,1‐a]isoquinolinones systems. Mechanistic studies and control experiment reveal that the reaction proceeds via imidazole‐directed ortho C(sp2)–H activation, followed by carbene C–H
Ganesh P. Pawar, Duc Huy Le, Li Ching Shen, Sheng‐Cih Huang, Chung‐Ming Sun   +4 more
wiley   +1 more source

Synthesis of Polysubstituted Isoquinolines through Cross-Coupling Reactions with α-Alkoxytosylhydrazones

, 2016
A Pd-catalyzed cross-coupling reaction of α-alkoxytosylhydrazones with sulfonates derived from salicyl aldehydes gives rise to protected 1,5-dicarbonyl compounds.
Lucía Florentino (2087203), Fernando Aznar (2087200), Carlos Valdés (1819675)   +2 more
core   +1 more source

Asymmetric Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in Situ as Activator

, 2017
By employing halogenide trichloroisocyanuric acid as a traceless activation reagent, a general iridium-catalyzed asymmetric hydrogenation of isoquinolines and pyridines is developed with up to 99% ee.
Mu-Wang Chen, Ji, Yue, Yong-Gui Zhou, Chen, Mu-Wang, Jie Wang, Yue Ji, Shi, Lei, Zhou, Yong-Gui, Chen, Qing-An, Qing-An Chen, Lei Shi, Wang, Jie   +11 more
core   +1 more source

Novel condensed isoquinolines with an enamine system

, 1970
Novel condensed imidazo-, pyrimido- and azepino-[1,2-b]isoquinolines having interesting enaminic properties have been obtained by pyrolysis of 1,2-, 1,3-and 1,4-diamine salts of homophthalic acid in boiling o-dichlorobenzene.
Ranga Rao, V., Shah, R. K., Nagarajan, K.   +2 more
core   +1 more source

Optimisation of a Novel Class of DNA Gyrase Inhibitors to Improve Antibacterial Activity

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
This article describes efforts to increase the antibacterial activity of a recently reported class of novel DNA gyrase inhibitors known as the isoquinoline sulphonamides by improving their uptake in bacterial cells. As antibiotic resistance continues to rise, the need for new antibacterials is clear.
Meg I. Ferguson, Cerissa C. van Walstijn, Vladyslav Lysenko, Marta A. Wilbrink, David Alencar Araripe, Jeroen M. Punt, Mario van der Stelt, Willem Jespers, Paolo Innocenti, Nathaniel I. Martin   +9 more
wiley   +1 more source

Targeting Fatty Acid Synthase With Berberine Promotes IL‐10 Production in Macrophages and Prevents Relapse in a Murine Colitis Model

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Berberine enhances IL‐10 production in macrophages via FASN‐dependent mechanisms, thereby promoting epithelial repair and preventing colitis relapse. Created with BioRender.com. ABSTRACT Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by alternating periods of remission and relapse.
Shusaku Hayashi, Yudai Ogawa, Nonoka Wakabayashi, Koga Tokuyama, Makito Oku, Takeshi Yamamoto, Shinichi Kato, Asma Nusrat, Makoto Kadowaki   +8 more
wiley   +1 more source