Results 111 to 120 of about 7,156 (173)

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 32, 24 August 2026.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source

From o‐Phenylenediamine to Flavin Derivatives: A Potential Prebiotic Carbon Skeleton Expansion With Formaldehyde, Cyanide, and CO2

Advanced Synthesis &Catalysis, Volume 368, Issue 16, 18 August 2026.
A Strecker‐type reaction of aromatic ortho‐diamines with various aldehydes and cyanide assembles the bicyclic amidine core of flavin‐derived heterocycles under mild conditions. Subsequent oxidation, radical or photochemical cyanation, carboxylation with CO2, and CO2‐mediated cyclization build the three‐ring alloxazine scaffold. This sequence provides a
Christian Held, Rodrigo José da Silva Lima, Ji‐Woong Lee   +2 more
wiley   +1 more source

Synthesis of Polysubstituted Isoquinolines through Cross-Coupling Reactions with α-Alkoxytosylhydrazones

, 2016
A Pd-catalyzed cross-coupling reaction of α-alkoxytosylhydrazones with sulfonates derived from salicyl aldehydes gives rise to protected 1,5-dicarbonyl compounds.
Lucía Florentino (2087203), Fernando Aznar (2087200), Carlos Valdés (1819675)   +2 more
core   +1 more source

Novel condensed isoquinolines with an enamine system

, 1970
Novel condensed imidazo-, pyrimido- and azepino-[1,2-b]isoquinolines having interesting enaminic properties have been obtained by pyrolysis of 1,2-, 1,3-and 1,4-diamine salts of homophthalic acid in boiling o-dichlorobenzene.
Ranga Rao, V., Shah, R. K., Nagarajan, K.   +2 more
core   +2 more sources

Guanine-functionalized MWCNT-supported Cu(I) magnetic nanocatalyst for green synthesis of isoquinolines in PEG/H₂O

Journal of Saudi Chemical Society
This study reports the development of a guanine-functionalized, multi-walled carbon nanotube (MWCNT)–supported copper(I) magnetic nanocatalyst designed to enable a rapid, green, three-component synthesis of isoquinolines.
Enas Daoud, Hussam Al-Din Haitham Kareem, Amina Dawood Suleman, Praharshkumar B. Raj, Subbulakshmi Ganesan, C. P. Surya, Lalita Chopra, Reza Mohammadi   +7 more
doaj   +1 more source

Asymmetric Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in Situ as Activator

, 2017
By employing halogenide trichloroisocyanuric acid as a traceless activation reagent, a general iridium-catalyzed asymmetric hydrogenation of isoquinolines and pyridines is developed with up to 99% ee.
Mu-Wang Chen, Ji, Yue, Yong-Gui Zhou, Chen, Mu-Wang, Jie Wang, Yue Ji, Shi, Lei, Zhou, Yong-Gui, Chen, Qing-An, Qing-An Chen, Lei Shi, Wang, Jie   +11 more
core   +1 more source

Novel dual kappa/mu opioid ligands based on a tetrahydroisoquinoline-valine hybrid nucleus

Scientific Reports
Opioid addiction constitutes a significant global health challenge. Kappa opioid receptor (KOP) modulators have demonstrated efficacy in treating resistant drug abuse cases.
Ahmad Abdelwaly, Hesham Safwan, Shamba Chatterjee, Mohamed Elsayed, Khaled M. Darwish, Amar Chittiboyina, Mohamed A. Helal   +6 more
doaj   +1 more source

Study of Cytotoxicity of Pyrrolo[3,4-<i>d</i>]isoxazoline and Pyrrolo[2,1-<i>a</i>]isoquinoline Derivatives Against Tumor Cell Lines. [PDF]

Int J Mol Sci
Drachuk AS, Mkrtchan SS, Shmakov SV, Vyazmin SY, Kim KA, Stepakov AV, Boitsov VM.   +6 more
europepmc   +1 more source

AcBr/DMSO Mediated Sulfenylation of Pyrrolo[2,1‑a]isoquinolines

We have developed a mild sulfenylation of pyrrolo­[2,1-a]­isoquinolines with acetyl bromide and dimethyl sulfoxide. A wide range of functionalized pyrrolo­[2,1-a]­isoquinolines could be prepared efficiently through the formation of a C–S bond with ...
Xiao-Hui Chen (543865), Hai-Lei Cui (2142391)   +1 more
core   +1 more source

Bromination of Pyrrolo[2,1‑a]isoquinolines with Acetyl Bromide and Dimethyl Sulfoxide

A mild bromination of pyrrolo­[2,1-a]­isoquinolines has been achieved using acetyl bromide and dimethyl sulfoxide. A series of brominated pyrrolo­[2,1-a]­isoquinolines could be obtained in moderate to excellent yields (46–99%) at room temperature.
Hai-Lei Cui (2142391)
core   +1 more source