Results 251 to 260 of about 29,358 (323)

Organocatalytic Enantioselective Addition of α-Aminoalkyl Radicals to Isoquinolines.

Organic Letters, 2018
With a dual organocatalytic system involving a chiral phosphoric acid and a dicyanopyrazine-derived chromophore (DPZ) photosensitizer and under the irradiation with visible light, an enantioselective Minisci-type addition of α-amino acid-derived redox ...
Xiangyuan Liu, Yang Liu, G. Chai, Baokun Qiao, Xiaowei Zhao, Zhiyong Jiang   +5 more
semanticscholar   +1 more source

An Overview of Privileged Scaffold: Quinolines and Isoquinolines in Medicinal Chemistry as Anticancer Agents.

Current Topics in Medicinal Chemistry, 2020
Cancer is one of the most difficult diseases and causes of death for many decades. Many pieces of research are continuously going on to get a solution for cancer.
Yanna Mao, Kunjal V. Soni, C. Sangani, Yongfang Yao   +3 more
semanticscholar   +1 more source

THE SYNTHESIS OF SOME ISOQUINOLINES

Canadian Journal of Research, 1949
A number of new isoquinolines substituted in the benzene nucleus have been prepared. The substituents include hydrazine-, chloro-, nitro-, and some combinations of these.
Marshall Kulka, Richard H. F. Manske
openaire   +3 more sources

Allylboration of Functionalized Isoquinolines.

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Fedor V. Pastukhov, Ilia V. Yampolsky, Yuri N. Bubnov, Yuri N. Bubnov   +3 more
openaire   +3 more sources

Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.

Journal of Medicinal Chemistry, 2019
Psoriasis is a common, chronic inflammatory disease characterized by abnormal skin plaques, and the effectiveness of phosphodiesterase 4 (PDE4) inhibitor to lessen the symptoms of psoriasis has been proved. Aiming to find a novel PDE4 inhibitor acting as
Xianglei Zhang, Guangyu Dong, Heng Li, Wu-yan Chen, Jian Li, Chun-lan Feng, Zhanni Gu, Feng-hua Zhu, R. Zhang, Minjun Li, Wei Tang, Hong Liu, Yechun Xu   +12 more
semanticscholar   +1 more source

Isoquinolines: Important Cores in Many Marketed and Clinical Drugs.

Anti-Cancer Agents in Medicinal Chemistry, 2020
BACKGROUND Isoquinoline analogs are an important, structurally diverse class of compounds that are extensively used as pharmaceuticals. Derivatives containing the isoquinoline scaffold have become a focus of therapeutic research because of their wide ...
C. Luo, Maxwell Ampomah-Wireko, Huanhuan Wang, Chunli Wu, Qing Wang, H. Zhang, Yaquan Cao   +6 more
semanticscholar   +1 more source

Enantioselective Hydrogenation of Isoquinolines

Angewandte Chemie International Edition, 2013
AbstractReview: [11 refs.]
Dongbing Zhao, Frank Glorius
openaire   +4 more sources

Cp*-Free Cobalt-Catalyzed C-H Activation/Annulations by Traceless N, O-Bidentate Directing Group: Access to Isoquinolines.

Organic Letters, 2019
N, O-Bidentate directing-enabled, traceless heterocycle synthesis is described via Cp*-free cobalt-catalyzed C-H activation/annulation. The weakly coordinating nature of the carboxylic acid was employed for the preparation of isoquinolines.
Xiaocai Li, Cong Du, He Zhang, Jun‐Long Niu, Mao‐Ping Song   +4 more
semanticscholar   +1 more source

The isoquinoline alkaloids

1971
1. ISOQUINOLINE ALKALOIDS - ORIGINS AND DEGREDATION 2. ss-PHENYLETHYLAMINES AND SIMPLE ISOQUINOLINES 2.1 Structures 2.2 Syntheses 2.3 Chemical Properties 2.4 Polymeric Isoquinolines 2.5 N-Benzylisoquinolines 2.6 1-Phenylisoquinolines 2.7 4-Phenylisoquinolines 2.8 Biogenesis 2.9 Pharmacology References 3.
J. E. Saxton, K. W. Bentley
openaire   +2 more sources

Gold-Catalyzed Atom-Economic Synthesis of Sulfone-Containing Pyrrolo[2,1-a]isoquinolines from Diynamides: Evidence for Consecutive Sulfonyl Migration

ACS Catalysis, 2019
A gold-catalyzed cascade reaction of conjugated diynamides has been developed. In this way, a series of sulfone-containing pyrrolo[2,1-a]isoquinolines featuring the core structural motifs of lamellarin alkaloids were prepared atom economically ...
Jibing Liu, P. Chakraborty, Heng Zhang, Liangshu Zhong, Zhi‐Xiang Wang, Xueliang Huang   +5 more
semanticscholar   +1 more source