Results 281 to 290 of about 29,358 (323)

Easy Access to 1-Amino and 1-Carbon Substituted Isoquinolines via Cobalt-Catalyzed CH/NO Bond Activation

, 2016
A green atom-economical method for the synthesis of highly functionalized 1-amino and 1-carbon substituted isoquinolines from the reaction of N′-hydroxybenzimidamides and aryl ketoximes, respectively, with alkynes via pentamethylcyclopentadienylcobalt ...
K. Muralirajan, R. Kuppusamy, S. Prakash, Chien‐Hong Cheng   +3 more
semanticscholar   +1 more source

Tandem Addition/Cyclization for Access to Isoquinolines and Isoquinolones via Catalytic Carbopalladation of Nitriles.

Organic Letters, 2017
The first example of the palladium-catalyzed sequential nucleophilic addition followed by an intramolecular cyclization of functionalized nitriles with arylboronic acids has been achieved, providing an efficient synthetic pathway to access structurally ...
Linjun Qi, Kun Hu, Shuling Yu, Jianghe Zhu, T. Cheng, Xiaodong Wang, Jiuxi Chen, Hua-yue Wu   +7 more
semanticscholar   +1 more source

Isoquinolines as receptors for resorcinol

Tetrahedron Letters, 1994
Abstract Multiple condensation reactions based on the Pictet-Gams isoquinoline synthesis lead to receptors for resorcinol. The host-guest interaction is confirmed by anisotropic highfield shifts and by NOE enhancement between aryl protons.
Gerald Dyker, Matthias Gabler, Mahmoud Nouroozian, Petra Schulz   +3 more
openaire   +2 more sources

Acid-Mediated Intermolecular [3 + 2] Cycloaddition toward Pyrrolo[2,1-a]isoquinolines: Total Synthesis of the Lamellarin Core and Lamellarin G Trimethyl Ether.

Organic Letters, 2017
A novel one-pot reaction has been developed for the efficient synthesis of pyrrolo[2,1-a]isoquinolines and 1-dearyllamellarin core from (E)-(2-nitrovinyl)benzenes and azomethine ylides generated in situ.
Kai-lu Zheng, Min-Qi You, Wen-Ming Shu, Yan‐Dong Wu, A. Wu   +4 more
semanticscholar   +1 more source

Construction of Tropane Derivatives by the Organocatalytic Asymmetric Dearomatization of Isoquinolines.

Angewandte Chemie, 2016
A chiral-NHC-catalyzed highly diastereo- and enantioselective dearomatizing double Mannich reaction of isoquinolines was developed that provides a powerful and straightforward synthetic route toward substituted tropane derivatives with four contiguous ...
Jin-Hui Xu, Sheng-Cai Zheng, Ji-Wei Zhang, Xin‐Yuan Liu, B. Tan   +4 more
semanticscholar   +1 more source

Practical and Asymmetric Reductive Coupling of Isoquinolines Templated by Chiral Diborons.

Journal of the American Chemical Society, 2017
We herein describe a chiral diboron-templated highly diastereoselective and enantioselective reductive coupling of isoquinolines that provided expedited access to a series of chiral substituted bisisoquinolines in good yields and excellent ee's under ...
Dong-Li Chen, Guang-Peng Xu, Qinghai Zhou, L. Chung, Wenjun Tang   +4 more
semanticscholar   +1 more source

ChemInform Abstract: Synthesis of Benzimidazo(2,1‐a)isoquinolines and 5,6‐ Dihydrobenzimidazo(2,1‐a)isoquinolines.

ChemInform, 1996
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Qun Sun, Edmond J. LaVoie
openaire   +3 more sources

Asymmetric Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in Situ as Activator.

Organic Letters, 2017
By employing halogenide trichloroisocyanuric acid as a traceless activation reagent, a general iridium-catalyzed asymmetric hydrogenation of isoquinolines and pyridines is developed with up to 99% ee.
Mu-Wang Chen, Yue Ji, Jie Wang, Qing‐An Chen, Lei Shi, Yong‐Gui Zhou   +5 more
semanticscholar   +1 more source

Cobalt(III)-Catalyzed C-H/N-O Functionalizations: Isohypsic Access to Isoquinolines.

Chemistry, 2015
C-H/N-O functionalizations by cobalt(III) catalysis allowed the expedient synthesis of a broad range of isoquinolines. Thus, internal and challenging terminal alkynes proved to be viable substrates for an isohypsic annulation, which was shown to proceed ...
Hui Wang, Julian Koeller, Weiping Liu, L. Ackermann   +3 more
semanticscholar   +1 more source

Cyanochlorination and cyanation of isoquinolines

Journal of the Chemical Society, Perkin Transactions 1, 1979
Treatment of isoquinoline with sulphuryl chloride and potassium cyanide gave, in one preparative step, 4-chloro-1-cyanoisoquinoline and 1-carbamoyl-3-cyanoisoquinoline in yields dependent upon the proportions of reagents. 4-Chloroisoquinoline, 1,3-dicyanoisoquinoline, 3-cyanoisoquinoline, and 1-cyanoisoquinoline were also produced under different ...
Seng Leong Tan, Gordon W. Kirby, Barrie C. Uff   +2 more
openaire   +2 more sources