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Rechallenge With Cisplatin After an Acute Coronary Event. [PDF]
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Associations of Brain Morphology and Cognitive Function With Ambulatory Estimated Pulse Wave Velocity. [PDF]
Cheng YB +7 more
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Rigid Biobased Vinylogous Urethane Vitrimers from d‑isosorbide/Furfural-Derived Monomers. [PDF]
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Isosorbide 5-Mononitrate Pharmacokinetics in Humans
Biopharmaceutics and Drug Disposition, 1981AbstractWhen isosorbide 5‐mononitrate was intravenously infused at a rate of 4 mg h −1 for 2.5 h to five human subjects, its concentrations in plasma increased slowly to 185 ng ml−1 ± 5 per cent C.V. at 2.5 h and a steady‐state plasma level was not reached during the infusion. When the infusion was discontinued, plasma drug concentrations declined with
E Doyle, L F Chasseaud, A Darragh
exaly +3 more sources
Isosorbide-5-mononitrate versus propranolol in the prevention of first bleeding in cirrhosis
Hemodynamic studies have shown the efficacy of nitrates in reducing portal pressure in cirrhosis. We therefore studied the efficacy of isosorbide-5-mononitrate vs. propranolol in the prevention of first bleeding within a prospective controlled trial.One hundred eighteen cirrhotics with esophageal varices were blindly randomized to receive 20 mg of ...
ANGELICO, MARIO +6 more
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Improved Extraction Procedure for the Assay of Isosorbide-5-Mononitrate in Serum
Journal of Chromatography B, Biomedical Sciences and Applications, 1996A procedure is described for the extraction of isosorbide-5-mononitrate from serum with diethyl ether-n-butyl acetate (15:1, v/v). After extraction, the diethyl ether is evaporated at room temperature and the nitrate remains dissolved in the relatively non-volatile n-butyl acetate phase. Glassware must be used throughout as the recovery of isosorbide-5-
J M, Pennings, J M, de Haas
exaly +3 more sources
Isosorbide 5-mononitrate kinetics
Clinical Pharmacology and Therapeutics, 1984The kinetics of isosorbide 5-mononitrate (5-ISMN) were studied in 12 healthy subjects after intravenous infusion and oral doses of 20 mg. Kinetic parameters calculated by model-independent methods or by assumption of a one-compartment open model were in good agreement.
R M, Major +4 more
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