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Metabolic fact of 14C-isosorbide 5-mononitrate in humans.

Arzneimittel-Forschung, 1984
Single oral doses of 20 mg of the carbon-14 labelled form of the antianginal drug isosorbide 5-mononitrate (5-ISMN, Elantan) were essentially completely absorbed and excreted fairly rapidly in the urine. Means of 24, 52, 78, 93 and 96% dose were excreted during 6, 12, 24, 48 and 120 h, respectively.
S G, Wood   +7 more
openaire   +1 more source

Oral isosorbide-5-mononitrate: pharmacokinetics and clinical efficacy.

International journal of clinical pharmacology, therapy, and toxicology, 1987
Isosorbide-5-mononitrate is a longer acting active metabolite than the parent drug, isosorbide dinitrate (ISDN), with a half-life of around 4 hours. In coronary heart disease, myocardial infarction and in heart failure it causes a typical nitrate action on the central hemodynamics, but due to a complete systemic availability with high and predictable ...
openaire   +1 more source

Long-Acting Isosorbide Mononitrate

Drugs, 1999
Amitabh Prakash   +2 more
exaly  

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