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A QSPR study of coronary artery disease drugs using eccentricity-based indices. [PDF]
Sci RepIqbal N +5 more
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Selective Intracoronary Injection of Nitrates Was Effective for Contrast Media-induced Type I Kounis Syndrome After Treatment with Steroids and Antihistamines. [PDF]
Intern MedKurokawa T +5 more
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JAMA, 1975
To evaluate whether there is cross-tolerance to the circulatory effects of isosorbide dinitrate and nitroglycerin, six subjects were given 120 mg/day of sustained-action isosorbide dinitrate in three divided doses for six to eight weeks. Prior to and during the last week of long-term isosorbide dinitrate administration, the effects of sublingually ...
Luciano A. Silvieri +1 more
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To evaluate whether there is cross-tolerance to the circulatory effects of isosorbide dinitrate and nitroglycerin, six subjects were given 120 mg/day of sustained-action isosorbide dinitrate in three divided doses for six to eight weeks. Prior to and during the last week of long-term isosorbide dinitrate administration, the effects of sublingually ...
Luciano A. Silvieri +1 more
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Pharmacokinetics of intravenous isosorbide-dinitrate
Journal of Pharmacokinetics and Biopharmaceutics, 1982The kinetics of isosorbide dinitrate (ISDN) after i.v. administration and the absolute availability of an oral slow release preparation (SR) were studied in young healthy volunteers. ISDN and the 2- and 5-mononitrates of isosorbide (2-MN, 5-MN) were determined by GLC. After i.v. administration plasma levels of ISDN declined biexponentially and could be
R, Platzer, G, Reutemann, R L, Galeazzi
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Isosorbide dinitrate in nephronophthisis treatment
American Journal of Medical Genetics Part A, 2018Nephronophthisis is a progressive disease that affects development of the renal tubules and leads to end stage renal disease. Many affected children have isolated renal disease; however, there can be additional manifestations including heart defects, liver fibrosis, brain malformations, and situs inversus. There is no way to slow or modify the disease.
Alanna Strong +4 more
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Polarographic Determination of Isosorbide Dinitrate
Journal of Pharmaceutical Sciences, 1976Isosorbide dinitrate and two isomeric isosorbide mononitrates are shown to be polarographically reducible in aqueous sodium perchlorate or potassium chloride solution. The current, measured at -1.6 v, versus the saturated calomel electrode is proportional to the concentration of organic nitrate in the 10-100-mug/ml range.
W R, Turner, R S, Lenkiewicz
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Biotransformation of Isosorbide Dinitrate in Humans
Journal of Pharmaceutical Sciences, 1974An oral dose of 14C-isosorbide dinitrate was rapidly absorbed and eliminated by human subjects. Up to 99% was excreted in the urine. The drug was completely biotransformed, nearly 50% to the principal metabolite, an isosorbide conjugate, presumably with glucuronic acid.
W H, Down, L F, Chasseaud, R K, Grundy
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Pharmacokinetics and pharmacodynamics of isosorbide dinitrate
American Heart Journal, 1985It has long been believed that organic nitrates, including isosorbide dinitrate (ISDN), are completely metabolized during their first passage through the liver and that oral therapy with this class of compounds is thus irrational. In the past few years, convincing data have been obtained in patients showing that intact ISDN is significantly ...
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