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Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model [PDF]

, 2012
Ovarian cancer is the leading cause of cancer related deaths in women. Genetic alterations including overexpression of EGFR play a crucial role in ovarian carcinogenesis.
Joseph Alan Bauer, Parul Gupta, Prabodh K. Kandala, Sanjay K. Srivastava, Sivakumar Loganathan   +4 more
core   +8 more sources

Anti-Cancer and Medicinal Potentials of Moringa Isothiocyanate

Molecules, 2021
Moringa oleifera (M. oleifera), which belongs to the Moringaceae family, is a common herb, rich in plant compounds. It has a variety of bioactive compounds that can act as antioxidants, antibiotics, anti-inflammatory and anti-cancer agents, etc., which ...
Yu-Yao Wu, Yan-Ming Xu, Andy T. Y. Lau
semanticscholar   +1 more source

Phenethyl Isothiocyanate Induces Apoptosis Through ROS Generation and Caspase-3 Activation in Cervical Cancer Cells

Frontiers in Pharmacology, 2021
The latest research shows that current chemotherapeutics are ineffective because of the development of resistance in cervical cancer cells, and hence, their scope of use is limited.
Shoaib Shoaib, Saba Tufail, M. Sherwani, N. Yusuf, N. Islam   +4 more
semanticscholar   +1 more source

Biosynthesis of Sinapigladioside, an Antifungal Isothiocyanate from Burkholderia Symbionts

ChemBioChem, 2021
Sinapigladioside is a rare isothiocyanate‐bearing natural product from beetle‐associated bacteria (Burkholderia gladioli) that might protect beetle offspring against entomopathogenic fungi.
Benjamin Dose, S. Niehs, K. Scherlach, Sophie Shahda, Laura V. Flórez, Martin Kaltenpoth, C. Hertweck   +6 more
semanticscholar   +1 more source

Apoptotic Potential of Glucomoringin Isothiocyanate (GMG-ITC) Isolated from Moringa oleifera Lam Seeds on Human Prostate Cancer Cells (PC-3)

Molecules, 2023
Inhibition of several protein pathways involved in cancer cell regulation is a necessary key in the discovery of cancer chemotherapy. Moringa oleifera Lam is often used in traditional medicine for the treatment of various illnesses.
Nurul Ashikin Abd Karim, Aziza Hussein Bakheit Adam, Mohammed Sani Jaafaru, Yaya Rukayadi, Ahmad Faizal Abdull Razis   +4 more
doaj   +1 more source

The phytopathogenic fungus Sclerotinia sclerotiorum detoxifies plant glucosinolate hydrolysis products via an isothiocyanate hydrolase

Nature Communications, 2020
Brassicales plants produce glucosinolates and myrosinases that generate toxic isothiocyanates conferring broad resistance against pathogens and herbivorous insects.
Jingyuan Chen, C. Ullah, M. Reichelt, F. Beran, Zhi-Ling Yang, J. Gershenzon, A. Hammerbacher, D. G. Vassão   +7 more
semanticscholar   +1 more source

Enantiopure (S)-butan-2-yl N-(4-x-phenyl)thiocarbamates, x = NO2, OCH3, F, and Cl

Acta Crystallographica Section E: Crystallographic Communications, 2023
The structures of (S)-butan-2-yl N-(4-nitrophenyl)thiocarbamate, C11H14N2O3S, (I), (S)-butan-2-yl N-(4-methoxyphenyl)thiocarbamate, C12H17NO2S, (II), (S)-butan-2-yl N-(4-fluorophenyl)thiocarbamate, C11H14FNOS, (III), and (S)-butan-2-yl N-(4-chlorophenyl ...
Werner Kaminsky, Max Kaganyuk
doaj   +1 more source

Optimization of Germination Process of Isothiocyanate Enrichment in Broccoli Sprouts by Response Surface Methodology

Shipin gongye ke-ji, 2022
The accumulation of isothiocyanate in germinated broccoli under ZnSO4-melatonin treatment was optimized. The isothiocyanate content, bud length and fresh weight of broccoli during germination were used as indices to study the effects of germination ...
Minglang GU, Yingqi GUO, Yongqi YIN, Xudong HE   +3 more
doaj   +1 more source

Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro

Molecules, 2020
Moringa oleifera Lam. is a tropical plant widely used in traditional medicines and as a food supplement. It is characterized by the presence of glucosinolates and isothiocyanates; the stable isothiocyanate 4-[(α-l-rhamnosyloxy)benzyl]isothiocyanate ...
Gigliola Borgonovo, L. De Petrocellis, A. Schiano Moriello, S. Bertoli, A. Leone, A. Battezzati, S. Mazzini, A. Bassoli   +7 more
semanticscholar   +1 more source

Anti‐pruritic effect of isothiocyanates: Potential involvement of toll‐like receptor 3 signaling

Pharmacology Research & Perspectives, 2022
The innate immune system has an emerging role as a mediator of neuro‐immune communication and a therapeutic target for itch. Toll‐like receptor 3 (TLR3) plays an important role in itch, as shown in TLR3 knock‐out mice.
Masaki Moriyama, Mitsuhiro Konno, Kanako Serizawa, Natsumi Yuzawa, Yuki Majima, Ikuo Hayashi, Tomohiko Suzuki, Mie Kainoh   +7 more
doaj   +1 more source