Results 311 to 320 of about 266,552 (386)

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

open access: yesCancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu   +12 more
wiley   +1 more source

MicroRNA-18b-5p Inhibits the Malignant Progression of Prostate Cancer Through Downregulating TRAF5. [PDF]

open access: yesInt J Gen Med
Wang X   +9 more
europepmc   +1 more source

Bioactivity profiles of progressively ring‐fluorinated cyclohexyl motifs in the WKYMVm peptide as formylpeptide FPR2 agonists and in keto‐piperazines as anti‐trypanosome agents.

open access: yesChemBioChem, Accepted Article.
A series of all‐cis ring fluorinated cyclohexylalanines with progressively increasing levels of vicinal fluorines, as well as 4‐fluorophenylalanine and pentafluoroarylphenylalanine were introduced into the WKYMVm peptide in place of its tyrosine residue, for assays against the G‐protein coupled formylpeptide receptor, FPR2.
David O'Hagan   +6 more
wiley   +1 more source

Mono‐Ethyl‐Phosphonates: Functional Group Masking Strategy to Stabilize and Optimize the Pharmacokinetics of Rare Earth Radiochelates

open access: yesChemistryEurope, EarlyView.
Prodrug strategies are used to enhance the pharmacokinetics of small molecule drugs. Here, this approach to rare earth coordination complexes is adopted with applications as diagnostic and therapeutic radiopharmaceuticals: a mono‐ethyl‐phosphonate polyazamacrocyclic chelator for 44Sc and 177Lu reduces blood and bone uptake.
Jennifer N. Whetter   +8 more
wiley   +1 more source

Monitoring Molecular Interactions with Cell Membranes Using Time-Dependent Second Harmonic Generation Microscopy. [PDF]

open access: yesBiochemistry
Hamal P   +7 more
europepmc   +1 more source

The Genuine Carbene Conundrum

open access: yesChemistry – A European Journal, EarlyView.
From fleeting intermediates to well‐defined molecular structures, carbenes (neutral divalent carbon) remind us that the most reactive ideas often make a large impact. Despite their wide‐ranging applications, the direct characterization of these reactive species remains a persistent experimental challenge.
Bethany Sawyer   +2 more
wiley   +1 more source

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