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Pharmacokinetics and pharmacodynamics of isothiocyanates

Drug Metabolism Reviews, 2011
Isothiocyanates from Brassica vegetables are of great interest for use in the cure of bacterial infections, as is their potential application in the prevention and treatment of cancer. Although much information is available on their mode of action within the cell, when it comes to the question of whether the necessary pharmacologic concentration has ...
Lamy, Evelyn   +3 more
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Inhibition of papain by isothiocyanates

Biochimica et Biophysica Acta (BBA) - Enzymology, 1976
During the tapping of papaya latex for papain (EC 3.4.22.2), benzyl isothiocyanate is enzymatically produced from benzylglucosinolate, a major component of the latex fluid. Benzyl isothiocyanate inhibits papain hydrolysis of alpha-N-benzoyl-L-arginine ethyl ester (Bz-Arg-OEt).
C S, Tang, W J, Tang
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Genotoxic effects of allyl isothiocyanate (AITC) and phenethyl isothiocyanate (PEITC)

Chemico-Biological Interactions, 2000
Two isothiocyanates (ITCs) commonly found in human diet, allyl isothiocyanate (AITC) and phenethyl isothiocyanate (PEITC), were tested for genotoxic effects in a battery of assays: Salmonella/microsome assay with TA 98 and TA 100, differential DNA repair assay with E. coli and micronucleus (MN) induction assay with human derived Hep G2 cells. Albeit to
F, Kassie, S, Knasmüller
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INHIBITION OF CARCINOGENESIS BY ISOTHIOCYANATES*

Drug Metabolism Reviews, 2000
Isothiocyanates occur as conjugates in a wide variety of cruciferous vegetables. Consumption of normal amounts of these vegetables results in the uptake of substantial quantities of isothiocyanates. These naturally occurring isothiocyanates as well as many synthetic analogs can be powerful inhibitors of carcinogenesis in laboratory animals ...
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Isothiocyanates of natural derivation

Pure and Applied Chemistry, 1963
Abstract
openaire   +1 more source

Isothiocyanates

2010
Elizabeth Jeffery, Anna-Sigrid Keck
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Isothiocyanates

Food and Chemical Toxicology, 1993
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Isothiocyanates

2005
S. Braverman, M. Cherkinsky, M. L. Birsa
openaire   +1 more source

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