Results 71 to 80 of about 140,334 (356)

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Total N difference method and 15N isotope dilution methode - A comparative study on N-fixation [PDF]

, 2002
In the study, the 15N fixation of a number of green manure crops were studied using either the 15N dilution technique, or the simple total N difference method.
Müller, Dr. Torsten, Thorup-Kristensen, Dr. Kristian   +1 more
core  

Butyltin compounds in a sediment core from the old Tilbury basin, London, UK [PDF]

, 2005
Sections from a sediment core taken from the River Thames were analysed for butyltin species using gas chromatography with species-specific isotope dilution mass spectrometry.
Almeida, Alzieu, Alzieu, Appleby, Bartlett, Batley, Bennett, Berg, Bhosle, Blunden, Booty, Broodbank, Burton, Chiron, Clark, Cundy, Dahllof, de Mora, Dowson, Dowson, Dowson, Dowson, Evans, Fent, Fent, Fernandez, Greeves, Harino, Hoch, Horiguchi, IMO, J.N. Lester, Jones, M.D. Scrimshaw, Midorikawa, R. Wahlen, Ramaswamy, Randall, Rodriguez-Gonzalez, Sarradin, Scrimshaw, Smith, Sturgeon, Sturgeon, Sudaryanto, T. Catterick, Thomas, Unger, Viglino, Voulvoulis, Voulvoulis, Wahlen, Wiese   +52 more
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Protein-protein interactions and metabolite channelling in the plant tricarboxylic acid cycle

Nature Communications, 2017
A metabolon is a complex of sequential metabolic enzymes that channels substrates directly between enzymes, thus optimizing metabolic flux. Here Zhanget al.
Youjun Zhang, Katherine F. M. Beard, Corné Swart, Susan Bergmann, Ina Krahnert, Zoran Nikoloski, Alexander Graf, R. George Ratcliffe, Lee J. Sweetlove, Alisdair R. Fernie, Toshihiro Obata   +10 more
doaj   +1 more source

Chemical Synthesis of Deoxynivalenol-3-β-d-[13C6]-glucoside and Application in Stable Isotope Dilution Assays

Molecules, 2016
Modified mycotoxins have been gaining importance in recent years and present a certain challenge in LC-MS/MS analysis. Due to the previous lack of a labeled isotopologue of the modified mycotoxin deoxynivalenol-3-glucoside, in our study we synthesized ...
Katharina Habler, Oliver Frank, Michael Rychlik   +2 more
doaj   +1 more source

Accurate and precise quantification of Cu,Zn-SOD in human red blood cells using species-specific double and triple IDMS [PDF]

, 2016
Acknowledgements This research was undertaken within the EMRP project HLT05. The EMRP was jointly funded by the EMRP participating countries within EURAMET and the European Union.
Feldmann, Jorg, Gleitzmann, Julia, Raab, Andrea, Schulze, Dirk, Swart, Claudia, Waetzig, Hermann   +5 more
core   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Phosphorus utilization in broilers fed with diets supplemented with different feed ingredients

Scientia Agricola
: A reliable determination of endogenous phosphorus (P) excretion is required to measure P utilization in chickens accurately. The objective of this study was to investigate phosphorus (P) retention in broilers fed diets formulated with different feed ...
Raquel Souza Dias, Secundino López, Laura Maria Oliveira Borgatti, Ermias Kebreab, Dorinha Miriam Silber Schmidt Vitti, Adibe Luiz Abdalla, Jayasooriya Arachchige Don Ranga Niroshan Appuhamy, James France   +7 more
doaj   +1 more source

Microscale Quantitative Analysis of Polyhydroxybutyrate in Prokaryotes Using IDMS

Metabolites, 2017
Poly(3-hydroxybutyrate) (PHB) is an interesting biopolymer for replacing petroleum-based plastics, its biological production is performed in natural and engineered microorganisms.
Mariana Itzel Velasco Alvarez, Angela ten Pierick, Patricia T. N. van Dam, Reza Maleki Seifar, Mark C. M. van Loosdrecht, S. Aljoscha Wahl   +5 more
doaj   +1 more source