Results 51 to 60 of about 100,704 (351)

Pyridine-based strategies towards nitrogen isotope exchange and multiple isotope incorporation

Nature Communications
Isotopic labeling is at the core of health and life science applications such as nuclear imaging, metabolomics and plays a central role in drug development. The rapid access to isotopically labeled organic molecules is a sine qua non condition to support
Minghao Feng, Maylis Norlöff, Benoit Guichard, Steven Kealey, Timothée D’Anfray, Pierre Thuéry, Frédéric Taran, Antony Gee, Sophie Feuillastre, Davide Audisio   +9 more
doaj   +1 more source

Unveiling the metabolic fate of monosaccharides in cell membranes with glycomic and glycoproteomic analyses. [PDF]

, 2019
Cell membrane protein glycosylation is dependent on the metabolic state of the cell as well as exogenous nutrients available. Although the metabolism and interconversion of monosaccharides have been well-studied, their incorporation into cell surface ...
Cheng, Zhi, Lebrilla, Carlito B, Li, Qiongyu, Park, Dayoung, Wong, Maurice, Xu, Gege   +5 more
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Nitrogen uptake and internal recycling in Zostera marina exposed to oyster farming: eelgrass potential as a natural biofilter [PDF]

, 2016
Oyster farming in estuaries and coastal lagoons frequently overlaps with the distribution of seagrass meadows, yet there are few studies on how this aquaculture practice affects seagrass physiology.
A Alexandre, A Alexandre, A Buhmann, A Cabello-Pasini, A Neori, Ana Alexandre, BJ Dudley, BR Dumbauld, BW Touchette, BW Touchette, C Buzzelli, CA Simenstad, CD Cornelisen, CM Maier, DH Ward, DM Booth, E Wagner, ET Apostolaki, FT Short, G Lepoint, G Lepoint, H Iizumi, H Peterson, H Peterson, HF Vinther, HF Vinther, HM Tallis, I Olivé, J Forde, J Stapel, J Stapel, J Terrados, J Zertuche-González, JA Vonk, JC Zieman, JM Burkholder, JM Hernández-Ayón, JM Ruiz, JM Sandoval-Gil, Jose Sandoval-Gil, JR Kelly, JW Fourqurean, K-S Lee, KJ McGlathery, L Rubio, LK Korhonen, LM Rasmusson, LM Wisehart, M Alkhatib, M Poumian-Tapia, M Ribas-Ribas, M Yamamuro, MA Hemminga, MA Hemminga, MA Hemminga, MA Skinner, MF Pedersen, MF Pedersen, ML Kellogg, N Hasegawa, N Marbá, O Invers, O Invers, RA Everett, RD Evans, Rui Santos, S García-Esquivel, S Sharma, T Alcoverro, T Alcoverro, TB Coplen, TBH Reusch, TJ Hoellein, VF Camacho-Ibar, Víctor F. Camacho-Ibar   +74 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Triple SILAC identified progestin-independent and dependent PRA and PRB interacting partners in breast cancer

Scientific Data, 2021
Measurement(s) progesterone receptor • isoform Technology Type(s) affinity purification method • stable isotope labeling by amino acids in cell culture Factor Type(s) progestin presence • biological replicate Machine-accessible metadata file describing ...
Prangwan Pateetin, Gyorgy Hutvagner, Matthew P. Padula, Eileen M. McGowan, Viroj Boonyaratanakornkit   +4 more
doaj   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

SIMPEL: using stable isotopes to elucidate dynamics of context specific metabolism

Communications Biology
The capacity to leverage high resolution mass spectrometry (HRMS) with transient isotope labeling experiments is an untapped opportunity to derive insights on context-specific metabolism, that is difficult to assess quantitatively.
Shrikaar Kambhampati, Allen H. Hubbard, Somnath Koley, Javier D. Gomez, Frédéric Marsolais, Bradley S. Evans, Jamey D. Young, Doug K. Allen   +7 more
doaj   +1 more source

Silkworm Pupae Function as Efficient Producers of Recombinant Glycoproteins with Stable-Isotope Labeling

Biomolecules, 2020
Baculovirus-infected silkworms are promising bioreactors for producing recombinant glycoproteins, including antibodies. Previously, we developed a method for isotope labeling of glycoproteins for nuclear magnetic resonance (NMR) studies using silkworm ...
Hirokazu Yagi, Saeko Yanaka, Rina Yogo, Akari Ikeda, Masayoshi Onitsuka, Toshio Yamazaki, Tatsuya Kato, Enoch Y. Park, Jun Yokoyama, Koichi Kato   +9 more
doaj   +1 more source

Spectral tracing of deuterium for imaging glucose metabolism. [PDF]

, 2019
Cells and tissues often display pronounced spatial and dynamical metabolic heterogeneity. Common glucose-imaging techniques report glucose uptake or catabolism activity, yet do not trace the functional utilization of glucose-derived anabolic products ...
Liu, Yinong, Miao, Yupeng, Min, Wei, Qian, Naixin, Shen, Yihui, Shi, Lingyan, Wei, Mian, Zhang, Luyuan   +7 more
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