Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome
Advanced Science, EarlyView.Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel +19 more
wiley +1 more source
Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy
Hepatology, EarlyView., 2022 Serum bile acid levels predict outcomes in patients with biliary atresia who achieve normalized bilirubin levels after Kasai portoenterostomy. Abstract Background and Aims In biliary atresia, serum bilirubin is commonly used to predict outcomes after Kasai portoenterostomy (KP).
Sanjiv Harpavat +22 more
wiley +1 more source
Frontiers in Earth Science, 2019 The capillary fringe is a subsurface terrestrial-aquatic interface that can be a significant hotspot for biogeochemical cycling of terrestrially derived organic matter and nutrients.
Nicholas J. Bouskill +8 more
doaj +1 more source
Birth Weight and Body Composition as Determined by Isotopic Dilution with Deuterium Oxide in 6- to 8-Year-Old South African Children. [PDF]
Children (Basel), 2022 Monyeki MA +6 more
europepmc +1 more source
Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits
Advanced Science, EarlyView.Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu +16 more
wiley +1 more source
Production and characterization of 60Fe standards for accelerator mass spectrometry.
PLoS ONE, 2019 Accelerator Mass Spectrometry (AMS) is one of the most sensitive analysis techniques to measure long-lived radionuclides, reaching detection limits for isotopic ratios down to 10-15-10-16 in special cases.
Dorothea Schumann +2 more
doaj +1 more source
Water Structure at the Hydrophobic Nanodroplet Surface Revealed by Vibrational Sum Frequency Scattering Using Isotopic Dilution. [PDF]
J Phys Chem B, 2022 Pullanchery S, Kulik S, Roke S.
europepmc +1 more source
Advanced Science, EarlyView.Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei +10 more
wiley +1 more source
Integrated Environmental Assessment and Management, EarlyView., 2023 Abstract In the Lake Koocanusa‐Kootenai River system (Montana, USA and British Columbia, Canada), selenium (Se) contamination has become an international concern and is suspected to contribute to the observed burbot (Lota lota) population collapse. Due to our limited ability to sample burbot in Lake Koocanusa for monitoring studies, we used a reference
Stephanie D. Graves +6 more
wiley +1 more source
Determination of Benzoic Acid and Benzyl Alcohol in E-Liquids (JUUL<sup>™</sup> Pods) by Isotopic Dilution High-Performance Liquid Chromatography and Tandem Mass Spectrometry. [PDF]
Contrib Tob Nicotine Res, 2021 Cardenas RB +2 more
europepmc +1 more source