Results 191 to 200 of about 67,280 (303)

Dominant‐Negative Effects of p53 R337 Variants in Li–Fraumeni Syndrome: Impact on Tetramer Formation and Transcriptional Activity

ChemBioChem, EarlyView.
Hetero‐tetramer dysfunction: Li–Fraumeni syndrome (LFS) is a hereditary cancer predisposition caused by mutations in the TP53 gene encoding the tumor suppressor p53. It is shown that p53 variants R337C and R337H, found in LFS, impair wild‐type (WT) p53 function by forming heterotetramers with reduced transcriptional activity.
Rui Kamada, Shuya Sakaguchi, Madoka Kanno, Takaaki Ozawa, Natsumi Nakagawa, James G. Omichinski, Kazuyasu Sakaguchi   +6 more
wiley   +1 more source

Isotopic Fractionation of Natural Uranium in Mice as a Potential Biomarker of Renal Accumulation. [PDF]

Environ Sci Technol
Lucey CM, Pearson BL, DeSantis K, Goldsmith J, Halliday AN, Navas-Acien A, Schilling K, Basu A.   +7 more
europepmc   +1 more source

Isotope dilution mass spectrometry of barium in sea water

, 1978
Masayo MUROZUMI, Hiroshi MITOBE, Seiji Nakamura, Hiroyuki Tsubota   +3 more
openalex   +2 more sources

Milligram‐Scale Enzymatic Synthesis of Base‐Modified DNA through Primer Extension: Polymerase Synthesis and NMR Structures of DNA Containing Phenyl‐Substituted Nucleobases

ChemistryEurope, EarlyView.
Larger‐scale enzymatic synthesis of base‐modified DNA is developed using primer extension with KOD(exo‐) DNA polymerase allowing preparation of milligram amounts of the modified DNA sufficient for NMR structural analysis. Milligram (≈200 nmol) scale enzymatic synthesis of base‐modified DNA is developed based on primer extension using easily accessible ...
Veronika Raindlová, Klára Viktorinová, Michal Tichý, Lucie Bednárová, Pavel Srb, Miguel Riopedre‐Fernandez, Michal Hocek   +6 more
wiley   +1 more source

How stable isotopes can advance nutrition assessments to inform sustainable food systems. [PDF]

Br J Nutr
Shertukde SP, De Sévaux MAJ, Herter-Aeberli I, Preston T, Loechl CU.   +4 more
europepmc   +1 more source

Assay of unesterified cholesterol-5,6-epoxide in human serum by isotope dilution mass spectrometry. Levels in the healthy state and in hyperlipoproteinemia.

, 1988
Ingemar Björkhem, Olof Breuer, B Angelin, S. -A. Wikström   +3 more
openalex   +1 more source

Redesigning a One‐Phase Enzymatic Assay to Streamline High‐Throughput Screening of Phytoene Desaturase Inhibitors

ChemFoodChem, EarlyView.
A one‐phase in vitro PDS enzyme activity assay is designed as a simple and efficient method, enabling the enhancement of substrate‐enzyme interaction and the elimination of the adverse effects of organic solvents on enzyme activity. It provides a rapid and direct evaluation method for high‐throughput screening of potent PDS inhibitors instead of using ...
Zhilei Yu, Dejun Ma, Di Zhang, Ding Jia, Chunxue Wang, Han Xu, Zhen Xi   +6 more
wiley   +1 more source

High-precision U-Pb data and reference age for Emerald Lake apatite. [PDF]

Data Brief
Apen FE, Gaynor SP, Schoene B.
europepmc   +1 more source

Total serum cholesterol by isotope dilution/mass spectrometry: a candidate definitive method.

, 1980
Alex Cohen, Harry S. Hertz, J Mandel, R C Paule, Robert Schaffer, Lorna T. Sniegoski, Tung Sun, Michael J. Welch, Edward White   +8 more
openalex   +1 more source

Inhibition of the Clathrin Terminal Domain—Amphiphysin Protein–Protein Interaction. Probing the Pitstop 2 Aromatic Moiety

ChemMedChem, EarlyView.
Pitstop 2 binds to the clathrin terminal domain. This work explores the nature of the benzylidene moiety, R. The synthesis of 56 novel analogues reveals enhanced potency of a multiple analogues, with catechol‐free 2,3‐dihydroxybenzo[b][1,4]dioxone (54) returning a 1.2 μm IC50, ca 10‐fold more active than Pitstop 2. Pitstop 2, (Z)‐N‐(5‐(4‐bromenzylidene)
Kate Prichard, Mark J Robertson, Ngoc Chau, Jing Xue, Martin Neuenschwander, Uwe Fink, Andre Horatscheck, Marc Nazare, Phillip J Robinson, Volker Haucke, Adam McCluskey   +10 more
wiley   +1 more source