Results 191 to 200 of about 68,403 (337)

Dominant‐Negative Effects of p53 R337 Variants in Li–Fraumeni Syndrome: Impact on Tetramer Formation and Transcriptional Activity

ChemBioChem, EarlyView.
Hetero‐tetramer dysfunction: Li–Fraumeni syndrome (LFS) is a hereditary cancer predisposition caused by mutations in the TP53 gene encoding the tumor suppressor p53. It is shown that p53 variants R337C and R337H, found in LFS, impair wild‐type (WT) p53 function by forming heterotetramers with reduced transcriptional activity.
Rui Kamada, Shuya Sakaguchi, Madoka Kanno, Takaaki Ozawa, Natsumi Nakagawa, James G. Omichinski, Kazuyasu Sakaguchi   +6 more
wiley   +1 more source

Isotope dilution mass spectrometry of barium in sea water

, 1978
Masayo MUROZUMI, Hiroshi MITOBE, Seiji Nakamura, Hiroyuki Tsubota   +3 more
openalex   +2 more sources

Functional Analysis of Histidine‐Dependent Self‐Cleaving RNAs Obtained by In Vitro Selection

ChemBioChem, EarlyView.
Ribozymes can be nucleic acid medicines given their catalytic activity. We attempted to obtain functional RNAs that mimic ribonuclease A catalytic mechanisms. Functional RNAs with high histidine specificity were obtained, suggesting that histidine acts in active structure formation.
Nae Sakimoto, Shoichiro Tanaka, Riki Hatakenaka, Yoshie Yamaguchi‐Miyazaki, Elisa Tomita‐Sudo, Tomoka Akita, Taku Ishigaki, Shigenori Iwai, Junji Kawakami   +8 more
wiley   +1 more source

Relationships among tissues, biofluids, and otolith selenium concentrations in wild female burbot (Lota lota)

Integrated Environmental Assessment and Management, EarlyView., 2023
Abstract In the Lake Koocanusa‐Kootenai River system (Montana, USA and British Columbia, Canada), selenium (Se) contamination has become an international concern and is suspected to contribute to the observed burbot (Lota lota) population collapse. Due to our limited ability to sample burbot in Lake Koocanusa for monitoring studies, we used a reference
Stephanie D. Graves, Noëlie Molbert, David M. Janz, Lauren D. Hayhurst, Jessica E. Brandt, Lauren Timlick, Vince P. Palace   +6 more
wiley   +1 more source

Determination of the Isotopic Composition of Indium by MC-ICP-MS Using an Improved Measurement Model for the Gravimetric Isotope Mixture Method. [PDF]

Anal Chem
Meija J, Nadeau K, Methven B, Yang L.
europepmc   +1 more source

Determination of Nd and Sm in standard rocks by "double spike" isotope dilution method of the mass spectrometry

, 1972
Kenji Notsu, Hisao MABUCHI, Minoru Ozima
openalex   +2 more sources

Isotope Dilution Method

Journal of the Mass Spectrometry Society of Japan, 1958
openaire   +3 more sources

Hydrogen‐Deuterium Exchange Defines Ligand‐Induced Conformational Changes to the Class III Biotin Protein Ligase from Saccharomyces cerevisiae

ChemBioChem, EarlyView.
Hydrogen‐deuterium exchange mass spectrometry validated AlphaFold structural prediction of the class III biotin protein ligase (BPL) from Saccharomyces cerevisiae, and revealed a structured domain in the N‐terminal extension characteristic to this class of BPL.
Louise M. Sternicki, Tara L. Pukala, Kamila J. Pacholarz, Perdita Barran, Grant W. Booker, Steven W. Polyak, Kate L. Wegener   +6 more
wiley   +1 more source

Tracing contamination in mining areas through sulfur and oxygen isotopes in groundwater sulfates: a case study from the Apuan Alps (Italy). [PDF]

Environ Geochem Health
Natali S, Franceschi L, Giannecchini R, D'Orazio M, Delgado-Huertas A, Zanchetta G, Doveri M.   +6 more
europepmc   +1 more source

Microanalysis of Lithium by Stable Isotope Dilution Method

, 1972
Satoshi Okada, Setsuo Taniguchi
openalex   +2 more sources