Results 71 to 80 of about 327,817 (261)

ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis

Advanced Science, EarlyView.
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Renesmee C. Kuo, Rohit Verma, Sydney C. Nagy, Mausam Kalita, Samuel Aubert, Josué Ballesteros‐Álvarez, Pedro Machado Almeida, Hannes Vogel, Israt S. Alam, Michael Lim, Michelle L. James   +10 more
wiley   +1 more source

Dry Blending to Achieve Isotopic Dilution of Highly Enriched Uranium Oxide Materials [PDF]

, 2001
The end of the cold war produced large amounts of excess fissile materials in the United States and Russia. The Department of Energy has initiated numerous activities to focus on identifying material management strategies for disposition of these excess ...
Rajamani, R. K., Henry, Roger Neil, Chipman, Nathan Alan   +2 more
core  

Determination of histamine in human plasma: the European external quality control study 1988 [PDF]

, 1990
There is an increasing interest in measuring human plasma histamine levels in various clinical conditions. A variety of 'old' and newly developed techniques are applied to meet this demand.
Lorenz, Wilfried, Neugebauer, E., W. LORENZ, Keyzer, J. J., E. COSTING, Oosting, E., E. NEUGEBAUER, J. J. KEYZER   +7 more
core   +1 more source

Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota

Advanced Science, EarlyView.
Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal, Ronald Garcia, Guangyi Chen, Chantal D. Bader, Peter Sullivan, Alexander Popoff, Daniel Krug, Maja Hunter, Sebastian Walesch, Emilia Oueis, Christine Frank, Haowen Zhao, Joachim J. Hug, Sebastian Keller, Pascal Hirsch, Azat Tagirdzhanov, Tatiana Malygina, Mary Victory E. Gutierrez, Alexey Gurevich, Judith Boldt, Boyke Bunk, Jörg Overmann, Ulrich Nübel, Andreas Keller, Olga V. Kalinina, Rolf Müller   +25 more
wiley   +1 more source

Isotopic dilution model for

, 2010
Chlorine-36 is one of the most critical radionuclides to consider in intermediate- and high-level nuclear waste management. Special attributes are long half-life, high mobility, biologically essential element, and massive isotopic dilution in the ...
M. I. Sheppard, N. Quittard, G. Echevarria, S. C. Sheppard, D. Vein, W. Van Hecke, M. Mignonneau   +6 more
core   +1 more source

Factors influencing the stable carbon isotopic composition of suspended and sinking organic matter in the coastal Antarctic sea ice environment [PDF]

, 2011
A high resolution time-series analysis of stable carbon isotopic signatures in particulate organic carbon (δ13CPOC) and associated biogeochemical parameters in sea ice and surface waters provides an insight into the factors affecting δ13CPOC in the ...
Carson, D. S., Ganeshram, R.S., R. S. Ganeshram, S. F. Henley, A. E. Fallick, Fallick, A.E., J. Dougans, A. Clarke, Ganeshram, R. S.; id_orcid, Annett, A.L., Annett, Amber, Weston, K., Henley, S.F., Annett, A. L., Ganeshram, R. S., Carson, D.S., D. S. Carson, K. Weston, Dougans, J., Fallick, A. E., A. L. Annett, Crosta, X., A. Tait, X. Crosta, Henley, S. F., Tait, A., Clarke, A.   +26 more
core   +2 more sources

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

Evidence for Microbial Mediated NO3− Cycling Within Floodplain Sediments During Groundwater Fluctuations

Frontiers in Earth Science, 2019
The capillary fringe is a subsurface terrestrial-aquatic interface that can be a significant hotspot for biogeochemical cycling of terrestrially derived organic matter and nutrients.
Nicholas J. Bouskill, Mark E. Conrad, Markus Bill, Eoin L. Brodie, Yiwei Cheng, Chad Hobson, Matthew Forbes, Karen L. Casciotti, Kenneth H. Williams   +8 more
doaj   +1 more source

Spatial and temporal variations in Pb concentrations and isotopic composition in road dust, farmland soil and vegetation in proximity to roads since cessation of use of leaded petrol in the UK [PDF]

, 2011
Results are presented for a study of spatial distributions and temporal trends in concentrations of lead (Pb) from different sources in soil and vegetation of an arable farm in central Scotland in the decade since the use of leaded petrol was terminated.
Scott, E.M., G. MacKinnon, MacKenzie, A.B., E.M. Scott, Duncan, H.J., Cook, G.T., A.B. MacKenzie, Pulford, I.D., G.T. Cook, MacKinnon, G., I.D. Pulford, H.J. Duncan   +11 more
core   +1 more source

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source