Results 141 to 150 of about 54,813 (313)

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Improved chemical and isotopic labeling of biomembranes in Bacillus subtilis by leveraging CRISPRi inhibition of beta-ketoacyl-ACP synthase (fabF). [PDF]

Front Mol Biosci, 2022
Nickels JD, Bonifer KS, Tindall RR, Yahya A, Tan L, Do C, Davison BH, Elkins JG.   +7 more
europepmc   +1 more source

Isotope‐labeled amyloid‐β does not transmit to the brain in a prion‐like manner after peripheral administration [PDF]

, 2022
Mirjam Brackhan, Giulio Calza, Kristiina Lundgren, Pablo Bascuñana, Thomas Brüning, Rabah Soliymani, Rakesh Kumar, Axel Abelein, Marc Baumann, Maciej Łałowski, Jens Pahnke   +10 more
openalex   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

Methylotroph Quorum Sensing Signal Identification by Inverse Stable Isotopic Labeling. [PDF]

ACS Chem Biol, 2021
Cummings DA, Snelling AI, Puri AW.
europepmc   +1 more source

1,2-Hydrogenation and Transhydrogenation Catalyzed by 3-Ketosteroid Δ1-Dehydrogenase from Sterolibacterium denitrificans—Kinetics, Isotope Labelling and QM:MM Modelling Studies [PDF]

, 2022
Agnieszka M. Wojtkiewicz, Michał Glanowski, Piotr Waligórski, Tomasz Janeczko, Maciej Szaleniec   +4 more
openalex   +1 more source

Remote Modulation of Single‐Atom Catalyst Boosts High‐Valent Cobalt–Oxo Species Generation for Water Purification and Detoxification

Advanced Science, EarlyView.
This study develops a phosphorus‐doped cobalt single‐atom catalyst that enhances high‐valent cobalt–oxo species generation for water purification. This atomic‐level tuning boosts the catalyst's activity by 3.5 times, enabling efficient pollutant degradation. A continuous‐flow reactor achieves high, long‐term removal efficiency, producing water with low
Wen‐Min Wang, Zheng‐Wei Yang, De‐Xiu Wu, Wen‐Long Wang, Qian‐Yuan Wu   +4 more
wiley   +1 more source

Isotope labeling strategies for NMR studies of RNA [PDF]

, 2009
Kun Lu, Yasuyuki Miyazaki, Michael F. Summers   +2 more
openalex   +1 more source

ENDOR spectroscopy of chlorophylls and the photosynthetic light conversion apparatus [PDF]

, 1979
Dolphin, D., Katz, Joseph J., Norris, James R., Scheer, Hugo   +3 more
core   +1 more source

Electron impact promoted fragmentation of alkyl-N-(1-Phenylethyl)-carbamates of primary, secondary and tertiary alcohols [PDF]

Mass spectra of alkyl carbamates derived from primary, secondary, and teriary alcohols by use of deuterium labeling and high resolution mass ...
Duffield, A. M., Halpern, B., Pereira, W. E., Solomon, M. D.   +3 more
core   +1 more source