Results 11 to 20 of about 54,813 (313)
Stable isotopic labeling in proteomics [PDF]
PROTEOMICS, 2008 AbstractLabeling of proteins and peptides with stable heavy isotopes (deuterium, carbon‐13, nitrogen‐15, and oxygen‐18) is widely used in quantitative proteomics. These are either incorporated metabolically in cells and small organisms, or postmetabolically in proteins and peptides by chemical or enzymatic reactions.
Gevaert, Kris +5 more
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Temporal dynamics of tree xylem water isotopes: in situ monitoring and modeling [PDF]
Biogeosciences, 2021 We developed a setup for a fully automated, high-frequency in situ monitoring system of the stable water isotope deuterium and 18O in soil water and tree xylem.
S. Seeger, M. Weiler
doaj +1 more source
Efficient Modeling of MS/MS Data for Metabolic Flux Analysis. [PDF]
PLoS ONE, 2015 Metabolic flux analysis (MFA) is a widely used method for quantifying intracellular metabolic fluxes. It works by feeding cells with isotopic labeled nutrients, measuring metabolite isotopic labeling, and computationally interpreting the measured ...
Naama Tepper, Tomer Shlomi
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Hot isopropanol quenching procedure for automated microtiter plate scale 13C-labeling experiments
Microbial Cell Factories, 2022 Background Currently, the generation of genetic diversity for microbial cell factories outpaces the screening of strain variants with omics-based phenotyping methods.
Jochen Nießer +4 more
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Analysis of isotopic labeling in peptide fragments by tandem mass spectrometry. [PDF]
PLoS ONE, 2014 Phenotype in multicellular organisms is the consequence of dynamic metabolic events that occur in a spatially dependent fashion. This spatial and temporal complexity presents challenges for investigating metabolism; creating a need for improved methods ...
Doug K Allen +2 more
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ISOTOPICS – ISOTOPIC LABELING FOR DRUG INNOVATION – H2020 [PDF]
Impact, 2017 ISOTOPICS (H2020 - Marie Sklodowska-Curie Actions - Innovative Training Network; grant number 675071) combines researchers and industry in an innovative effort to de-risk drug development, create new tools for medicine and train first-class radiochemists with dual academic-industrial expertise.
Dugave, Christophe, Hinsinger, Karen
openaire +2 more sources
Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis
eLife, 2020 Brown adipose tissue (BAT) is composed of thermogenic cells that convert chemical energy into heat to maintain a constant body temperature and counteract metabolic disease.
Vanja Panic +15 more
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Partial (13)C isotopic enrichment of nucleoside monophosphates: useful reporters for NMR structural studies [PDF]
, 2005 Analysis of the (13)C isotopic labeling patterns of nucleoside monophosphates (NMPs) extracted from Escherichia coli grown in a mixture of C-1 and C-2 glucose is presented. By comparing our results to previous observations on amino acids grown in similar
Kishore, Anita I. +2 more
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Bacillimidazoles A−F, Imidazolium-Containing Compounds Isolated from a Marine Bacillus
Marine Drugs, 2022 Chemical investigations of a marine sponge-associated Bacillus revealed six new imidazolium-containing compounds, bacillimidazoles A–F (1–6). Previous reports of related imidazolium-containing natural products are rare.
Jia-Xuan Yan +10 more
doaj +1 more source
BMC Bioinformatics, 2019 Background The investigation of intracellular metabolism is the mainstay in the biotechnology and physiology settings. Intracellular metabolic rates are commonly evaluated using labeling pattern of the identified metabolites obtained from stable isotope ...
Di Du +7 more
doaj +1 more source