Results 161 to 170 of about 197,507 (284)

Preclinical development of ABL206, a novel bispecific antibody-drug conjugate targeting B7-H3 and ROR1. [PDF]

MAbs
Kwon JA, Lee S, Kim J, Yoo BM, Park HJ, Ryu I, Kim J, Eom J, Son YG, Yeom D, Sung B, Yoo M, Seo A, Yoo J, Park JY, Jung J, Ahn J, You WK, Lee SH, Ko MJ.   +19 more
europepmc   +1 more source

isotype control

Citation: 'isotype control' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13348 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Plasma Membrane Lipid Asymmetry Dynamically Regulates Passive Diffusion

Advanced Science, EarlyView.
Passive diffusion enables hydrophobic molecules to cross the plasma membrane and exert their biological functions. This study demonstrates that plasma membrane lipid asymmetry, dynamically regulated by lipid scrambling, determines membrane permeability to lipophilic molecules and thereby modulates their cellular activities.
Jieming Ping, Wenliang Wang, Jinnuo Xu, Mengyun Yang, Ning Wu   +4 more
wiley   +1 more source

Preclinical evaluation of SLC35D3-targeted CAR-T cells for tumor-selective immunotherapy. [PDF]

Biochem Biophys Rep
Someya S, Ming M, Tomisato W, Fukuchi K, Ohtsuka T, Kawaida R.   +5 more
europepmc   +1 more source

Rational Surface Engineering Reduces Advanced Glycation End‐Product Adsorption and Improves Implant Integration

Advanced Science, EarlyView.
Targeted surface chemical modification prevents the accumulation of advanced glycation end products (AGEs) on implant surfaces, attenuates inflammation and fibrosis, effectively restores angiogenic activity, and improves osseointegration under diabetic conditions.
Thien Ngoc Le, Wenhao Chen, Tengxiao Huang, Tien Thanh Nguyen, Markos Negash Alemie, Xuan Duy Do, Giles Best, Jordan Li, Jitraporn Vongsvivut, Vi‐Khanh Truong, Weiwei Li, Yunpeng Zhao, Richard Bright, Krasimir Vasilev   +13 more
wiley   +1 more source

Early HHV-6 IgG and IgA responses during acute SARS-CoV-2 infection in relation to long COVID: a multicohort observational study. [PDF]

EBioMedicine
Choudhury A, Burry MJ, Kwon WJ, Yin X, Rallistan A, Presti S, Ndakwah GS, Cheng EQ, Kalaycioglu M, Harris M, Frankovich J, Karlson EW, Bollyky J, Utz PJ, Prestwood TR.   +14 more
europepmc   +1 more source

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

FOLR1-targeted actinium-225-based alpha-particle therapy eliminates ovarian cancer. [PDF]

Sci Adv
Singh N, Need E, Berndt A, Goff M, Wilson LJ, Mourtada F, Guo F, Mastren T, Al-Hilal T, Sood AK, Maity A, Miller SC, Minoshima S, Goel S, Shi S.   +14 more
europepmc   +1 more source

Optimizing Electrode Design for Functional Activation of Human Pluripotent Stem Cell‐Derived Cardiomyocytes

Advanced NanoBiomed Research, EarlyView.
Electrical stimulation of human pluripotent stem cell‐derived cardiomyocytes is systematically investigated as a function of electrode material and configuration. Stimulation efficiency is found to be governed predominantly by electrode geometry, with increased electrode area and proximity to cells enabling more effective pacing.
Gustavo Ramirez‐Calderon, Abdulelah Saleh, Tania Cecilia Hidalgo Castillo, Anil Koklu, Adel Hama, Gabriel Herrera‐Lopez, Veronica Astro, Yazmin Hernández Mustafá, Plácido D. Jorge Collet, Lamia Bin Thuwaini, Pierre J. Magistretti, Antonio Adamo, Sahika Inal   +12 more
wiley   +1 more source

CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source