Evolution of the Immunoglobulin Isotypes—Variations of Biophysical Properties among Animal Classes [PDF]
Biomolecules, 2023 The adaptive immune system arose around 500 million years ago in jawed fish, and, since then, it has mediated the immune defense against pathogens in all vertebrates.
Klaus R. Liedl +2 more
exaly +6 more sources
Immunoglobulin isotypes in Atlantic salmon, Salmo salar. [PDF]
Biomolecules, 2015 There are three major immunoglobulin (Ig) isotypes in salmonid fish: IgM, IgD and IgT, defined by the heavy chains μ, δ and τ, respectively. As a result of whole genome duplication in the ancestor of the salmonid fish family, Atlantic salmon (Salmo salar)
Hordvik I.
europepmc +10 more sources
B cells defined by immunoglobulin isotypes. [PDF]
Clin Exp Immunol, 2022 Summary The ability of B cells to generate antibodies and provide long-lived protective immunity is the cornerstone of vaccination and has contributed to the success of modern medicine.
James LK.
europepmc +5 more sources
Intratumoral immunoglobulin isotypes predict survival in lung adenocarcinoma subtypes. [PDF]
J Immunother Cancer, 2019 Background The role of tumor-infiltrating B-cells (TIBs) and intratumorally-produced antibodies in cancer-immunity interactions essentially remains terra incognita.
Isaeva OI +6 more
europepmc +3 more sources
Detection of immunoglobulin isotypes from dried blood spots [PDF]
Journal of Immunological Methods, 2014 The study was designed to determine the sensitivity and reproducibility of recovering immunoglobulin (Ig) isotypes (IgG subclasses, IgA, IgE and IgM classes) from dried blood spots (DBS), a methodologic subcomponent of the Upstate KIDS Study.
Germaine M Buck Louis +2 more
exaly +3 more sources
Development of quantitative suspension array assays for six immunoglobulin isotypes and subclasses to multiple Plasmodium falciparum antigens. [PDF]
J Immunol Methods, 2018 Background Quantitative suspension arrays are powerful immunoassays to measure antibodies against multiple antigens in large numbers of samples in a short time and using few microliters.
Vidal M, Aguilar R, Campo JJ, Dobaño C.
europepmc +2 more sources
Utility of immunoglobulin isotypes against LID-1 and NDO-LID for, particularly IgG1, confirming the diagnosis of multibacillary leprosy. [PDF]
Mem Inst Oswaldo Cruz, 2018 BACKGROUND Leprosy remains a health problem in many countries, with difficulties in diagnosis resulting in delayed treatment and more severe disabilities.
Marçal PHF +8 more
europepmc +2 more sources
Viruses, 2023 Females often exhibit superior immune responses compared to males toward vaccines and pathogens such as influenza viruses and SARS-CoV-2. To help explain these differences, we first studied serum immunoglobulin isotype patterns in C57BL/6 male and female
Rhiannon R Penkert +2 more
exaly +3 more sources
Frontiers in Immunology, 2017 Binding of the complement component C1q to the CH2 domain of antigen-bound immunoglobulin gamma (IgG) activates the classical complement pathway and depends on its close proximity to Fc fragments of neighboring antibodies. IgG subclasses contain a highly
Benjamin Peschke +6 more
doaj +2 more sources
Kappa free light chain index in CSF diagnostics: the impact of different immunoglobulin isotypes. [PDF]
Front ImmunolBackgroundThe kappa free light chain (κ-FLC) index is a sensitive marker of intrathecal immunoglobulin (Ig) synthesis and is increasingly used in cerebrospinal fluid (CSF) analysis of patients with suspected multiple sclerosis (MS).
Schmidauer M +9 more
europepmc +2 more sources