Results 41 to 50 of about 20,447 (254)

Analysis of serum immunoglobulin isotypes.

, 2016
Serum from Ly-6A/Sca-1-/- and wild-type (WT) female mice was analyzed via Cytometric Bead Array that specifically detect immunoglobulin heavy and light (κ & λ) chains by flow cytometer.
Vimvara Vacharathit (2847590), Sean DeWolf (2847593), Morgan A. Jones (2847581), Anil K. Bamezai (2847584), Michelle Yim (2847587), Stacey Spencer (2847578)   +5 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Interactions between Gold Nanoparticles and Immunoglobulin Isotypes

, 2021
Gold Nanoparticles have piqued interest for use in a wide range of diagnostic and therapeutic applications including biosensors, assays, vaccine development, drug delivery, and photothermal therapy.
Hassan, Rick
core  

Functions of IgM fc receptor (FcµR) related to autoimmunity

Autoimmunity
Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as evidenced by concomitant production of autoantibodies of ...
Hiromi Kubagawa, Pedram Mahmoudi Aliabadi, Khlowd Al-Qaisi, Peter K. Jani, Kazuhito Honjo, Shozo Izui, Andreas Radbruch, Fritz Melchers   +7 more
doaj   +1 more source

Immunoglobulin D multiple myeloma, plasma cell leukemia and chronic myelogenous leukemia in a single patient treated simultaneously with lenalidomide, bortezomib, dexamethasone and imatinib

Hematology Reports, 2016
Multiple myeloma (MM) is a neoplastic lymphoproliferative disorder characterized by uncontrolled monoclonal plasma cell proliferation. Among different isotypes of MM, immunoglobulin D (IgD) MM is very rare, representing only 1 to 2% of all isotypes ...
Naveed Ali, Peter V. Pickens, Herbert E. Auerbach   +2 more
doaj   +1 more source

Immunoglobulin profile and B‐cell frequencies are altered with changes in the cellular microenvironment independent of the stimulation conditions

Immunity, Inflammation and Disease, 2020
Introduction B‐cells are essential in the defense against Mycobacterium tuberculosis. Studies on isolated cells may not accurately reflect the responses that occur in vivo due to the presence of other cells.
Dannielle K. Moore, Gina R. Leisching, Candice I. Snyders, Andrea Gutschmidt, Ilana C. vanRensburg, Andre G. Loxton   +5 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Features of Isotypic Structure of Virus-Specific Systemic Humoral Immune Response in Adult Volunteers Immunized with Inactivated Monovalent Subunit Vaccines against Pandemic Influenza A(H1N1)pdm09

Эпидемиология и вакцинопрофилактика, 2016
An isotypic structure of system antibody response to influenza A(H1N1)pdm09 was analyzed in adult volunteers vaccinated with two inactivated monovalent subunit vaccines against pandemic influenza.
A. A. Vasileva, V. Z. Krivitskaya, E. M. Vojcekhovskaya, V. S. Vakin, E. V. Kuznecova, E. R. Petrova, A. A. Go, N. I. Lvov, A. A. Sominina   +8 more
doaj   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Local hepatic immune response in rats during primary infection with Fasciola hepatica

Parasite, 2000
The distribution of lymphocyte subpopulations (TCD4+ , TCD8+, TCD43+ and Ig+ cells), macrophages and eosinophils were analysed in the inflammatory infiltrates associated with hepatic lesions and in hepatic lymph nodes (HLN) from rats experimentally ...
Tliba O., Sibille P., Boulard C., Chauvin A.   +3 more
doaj   +1 more source