Results 41 to 50 of about 478,815 (317)

Supplementary Table S1: Properties of Antibody Isotypes from Targeting PD-1 or PD-L1 in Metastatic Kidney Cancer: Combination Therapy in the First-Line Setting

, 2020
Immunoglobulin Isotypes and Relative Biologic ...
David H. Aggen (15027077), Brian I. Rini (9081440), Charles G. Drake (7549529)   +2 more
core   +1 more source

Immunopathology of rabies infection in mice selected for high or low acute inflammatory reaction

Journal of Venomous Animals and Toxins including Tropical Diseases, 2007
Rabies is a severe and lethal disease that produces a slight inflammatory response during the infection process. We analyzed the immunopathological mechanisms that occur in the central nervous system (CNS) using mice genetically selected for maximal or ...
S. M. Achkar, I. L. Sinhorini, O. G. Ribeiro, M. L. Carrieri, R. S. Ceretta, C. A. Consales   +5 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Functions of IgM fc receptor (FcµR) related to autoimmunity

Autoimmunity
Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as evidenced by concomitant production of autoantibodies of ...
Hiromi Kubagawa, Pedram Mahmoudi Aliabadi, Khlowd Al-Qaisi, Peter K. Jani, Kazuhito Honjo, Shozo Izui, Andreas Radbruch, Fritz Melchers   +7 more
doaj   +1 more source

Immunoglobulin D multiple myeloma, plasma cell leukemia and chronic myelogenous leukemia in a single patient treated simultaneously with lenalidomide, bortezomib, dexamethasone and imatinib

Hematology Reports, 2016
Multiple myeloma (MM) is a neoplastic lymphoproliferative disorder characterized by uncontrolled monoclonal plasma cell proliferation. Among different isotypes of MM, immunoglobulin D (IgD) MM is very rare, representing only 1 to 2% of all isotypes ...
Naveed Ali, Peter V. Pickens, Herbert E. Auerbach   +2 more
doaj   +1 more source

Immunoglobulin profile and B‐cell frequencies are altered with changes in the cellular microenvironment independent of the stimulation conditions

Immunity, Inflammation and Disease, 2020
Introduction B‐cells are essential in the defense against Mycobacterium tuberculosis. Studies on isolated cells may not accurately reflect the responses that occur in vivo due to the presence of other cells.
Dannielle K. Moore, Gina R. Leisching, Candice I. Snyders, Andrea Gutschmidt, Ilana C. vanRensburg, Andre G. Loxton   +5 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Features of Isotypic Structure of Virus-Specific Systemic Humoral Immune Response in Adult Volunteers Immunized with Inactivated Monovalent Subunit Vaccines against Pandemic Influenza A(H1N1)pdm09

Эпидемиология и вакцинопрофилактика, 2016
An isotypic structure of system antibody response to influenza A(H1N1)pdm09 was analyzed in adult volunteers vaccinated with two inactivated monovalent subunit vaccines against pandemic influenza.
A. A. Vasileva, V. Z. Krivitskaya, E. M. Vojcekhovskaya, V. S. Vakin, E. V. Kuznecova, E. R. Petrova, A. A. Go, N. I. Lvov, A. A. Sominina   +8 more
doaj   +1 more source

Analysis of serum immunoglobulin isotypes.

, 2016
Serum from Ly-6A/Sca-1-/- and wild-type (WT) female mice was analyzed via Cytometric Bead Array that specifically detect immunoglobulin heavy and light (κ & λ) chains by flow cytometer.
Vimvara Vacharathit (2847590), Sean DeWolf (2847593), Morgan A. Jones (2847581), Anil K. Bamezai (2847584), Michelle Yim (2847587), Stacey Spencer (2847578)   +5 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source