Results 61 to 70 of about 478,815 (317)
Advanced Science, EarlyView.Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke +10 more
wiley +1 more source
FEBS Open Bio, 2021 Immunoglobulin E (IgE) is a central regulatory and triggering molecule of allergic immune responses. IgE’s interaction with CD23 modulates both IgE production and functional activities.CD23 is a noncanonical immunoglobulin receptor, unrelated to ...
Veronica F. Ilkow +5 more
doaj +1 more source
MOESM1 of Intratumoral immunoglobulin isotypes predict survival in lung adenocarcinoma subtypes
, 2019 Additional file 1: Figure S1. Non-silent mutation burden correlates with IGHG1/IGH proportion in LUAD subgroups. Figure S2. IgG1 clonality. Figure S3. Exploring IGH motifs linked to IgG1-mediated survival in KRASmut LUAD. Figure S4.
G. Sharonov (7587482) +6 more
core +1 more source
Acquisition of antibody isotypes against Plasmodium falciparum blood stage antigens in a birth cohort. [PDF]
, 2010 Information on the period during which infants lose their maternally derived antibodies to malaria and begin to acquire naturally their own immune responses against parasite antigens is crucial for understanding when malaria vaccines may be best ...
Duah, NO +7 more
core +1 more source
Advanced Science, EarlyView.Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin +7 more
wiley +1 more source
A theory of allelic and isotypic exclusion for immunoglobulin genes. [PDF]
Proceedings of the National Academy of Sciences, 1982 Heavy (H) chain binding protein (BiP), which binds to free immunoglobulin H chain of the mu and gamma classes, can be demonstrated in pre-B-cells. It is proposed that the displacement of BiP from H chain by light (L) chain terminates the activity of the enzyme system, L-generase, which catalyzes DNA rearrangement at the L chain loci, generating the ...
Wabl, M., Steinberg, C.
openaire +3 more sources
Immunoglobulin isotypes and IgG subclasses in recurrent infections
The Turkish Journal of Pediatrics, 1997 The frequency of major immunoglobulin isotype and IgG subclass deficiencies among 74 children aged six months to 14 years with recurrent infections was studied.
Y Coşkun, Z Bayraktaroğlu
doaj
The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy
Advanced Science, EarlyView.Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi +11 more
wiley +1 more source
Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer
Advanced Science, EarlyView.Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.
Meng Qian +11 more
wiley +1 more source
Variant B cell receptor isotype functions differ in hairy cell leukemia with mutated BRAF and IGHV genes. [PDF]
PLoS ONE, 2014 A functional B-cell receptor (BCR) is critical for survival of normal B-cells, but whether it plays a comparable role in B-cell malignancy is as yet not fully delineated.
Nicola J Weston-Bell +3 more
doaj +1 more source