Results 61 to 70 of about 20,447 (254)

A theory of allelic and isotypic exclusion for immunoglobulin genes. [PDF]

Proceedings of the National Academy of Sciences, 1982
Heavy (H) chain binding protein (BiP), which binds to free immunoglobulin H chain of the mu and gamma classes, can be demonstrated in pre-B-cells. It is proposed that the displacement of BiP from H chain by light (L) chain terminates the activity of the enzyme system, L-generase, which catalyzes DNA rearrangement at the L chain loci, generating the ...
Wabl, M., Steinberg, C.
openaire   +3 more sources

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Isotype specific ELISAs to detect antibodies against swine vesicular disease virus and their use in epidemiology

, 2002
Isotype specific ELISAs to detect antibodies against swine vesicular disease, which may help to estimate the moment of infection, were developed and validated on sera from pigs experimentally infected with four different isolates of swine vesicular ...
Dekker, A., Hemert-Kluitenberg, F., van, Terpstra, C., Baars-Lorist, C.A., van Hemert-Kluitenberg, F.   +4 more
core   +1 more source

Reviving lost binding sites: Exploring calcium‐binding site transitions between human and murine CD23

FEBS Open Bio, 2021
Immunoglobulin E (IgE) is a central regulatory and triggering molecule of allergic immune responses. IgE’s interaction with CD23 modulates both IgE production and functional activities.CD23 is a noncanonical immunoglobulin receptor, unrelated to ...
Veronica F. Ilkow, Anna M. Davies, Balvinder Dhaliwal, Andrew J. Beavil, Brian J. Sutton, James M. McDonnell   +5 more
doaj   +1 more source

The Characterization of Disease Severity Associated IgG Subclasses Response in COVID-19 Patients

Frontiers in Immunology, 2021
Increasing evidence suggests that dysregulated immune responses are associated with the clinical outcome of coronavirus disease 2019 (COVID-19). Nucleocapsid protein (NP)-, spike (S)-, receptor binding domain (RBD)- specific immunoglobulin (Ig) isotypes,
Huanle Luo, Huanle Luo, Tingting Jia, Jiamin Chen, Shike Zeng, Zengzhao Qiu, Shu Wu, Xu Li, Yuxuan Lei, Xin Wang, Weihua Wu, Renli Zhang, Xuan Zou, Tiejian Feng, Ruxia Ding, Yue Zhang, Yao-Qing Chen, Yao-Qing Chen, Caijun Sun, Caijun Sun, Tian Wang, Tian Wang, Tian Wang, Shisong Fang, Yuelong Shu, Yuelong Shu   +25 more
doaj   +1 more source

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

Levels of immunoglobulin (Ig) isotypes recognizing HIV-1 envelope proteins gp120 and gp41 in the cervicovaginal lavages (CVLs) of HESN and HIV-1 infected CSW women.

, 2019
Levels of immunoglobulin isotypes recognizing gp120 of HIV-1 (A) IgG1, IgG2 and IgG3, (C) IgA1, IgA2 and IgM, and immunoglobulin isotypes recognizing gp41 of HIV-1 (B) IgG1, IgG2 and IgG3, and (D) IgA1, IgA2 and IgM.
Victoire Perraud (6812498), Catherine Sabourin-Poirier (6812495), Marie-Claude Faucher (2940057), Michel Roger (152025), Michel Alary (180020), Lyvia Fourcade (6812492), Josiane Chagnon-Choquet (594672), Johanne Poudrier (152016), Fernand Guédou (6812501), Annie-Claude Labbé (69266)   +9 more
core   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Analysis of antibody isotypes.

, 2016
Anti-Pvs48/45 sera showing positive reactivity to Pfs48/45 in ELISA and Western blotting (4 out of 5 from CFA group and 2 out of 5 from Montanide ISA-51 group) were individually tested to compare immunoglobulin isotypes. ELISA plates coated with Pvs48/45
Yi Cao (229829), Geetha P. Bansal (3149496), Kristen Merino (3149499), Nirbhay Kumar (113311)   +3 more
core   +1 more source