Results 81 to 90 of about 478,815 (317)

Most B cells that have switched surface immunoglobulin isotypes generate clones of cells that do not secrete IgM.

Journal of Immunology, 1981
The order of genes coding for the constant regions of immunoglobulin heavy chains is 5'-C mu, C delta, C gamma 3, C gamma 1, C gamma 2b, C gamma 2a, C epsilon, C alpha-3'.
P. Gearhart, J. Cebra
semanticscholar   +1 more source

Checkpoint‐Directed Glycoengineering Reprograms the Vascular Lumen for Siglec‐Mediated Immune Regulation

Advanced Science, EarlyView.
Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Md Mohosin Rana, Javairia F. Rahim, Aaron P. Bernstein, Peyman Malek Mohammadi Nouri, Lyann Sim, Winnie Enns, Jenice M. Dumlao, Haiming D. Luo, Irina Chafeeva, Hong‐Ming Chen, Aizhou Wang, Jiao‐Jing Wang, Edward N. Schmidt, Zheng Jenny Zhang, Marcelo Cypel, Christopher Nguan, Matthew S. Macauley, Stephen G. Withers, Jonathan C. Choy, Jayachandran N. Kizhakkedathu   +19 more
wiley   +1 more source

Distribution of immunoglobulin isotypes and subisotypes in equine guttural pouch (auditory tube diverticulum).

Journal of Veterinary Medical Science, 2000
To clarify the functions of the equine guttural pouch, the distribution of various immunoglobulin isotypes and subisotypes in the guttural pouch mucosa were examined in healthy horses.
Dugarjaviin Manglai, R. Wada, M. Kurohmaru, T. Sugiura, T. Yoshihara, Masa-aki Oikawa, Yoshihiro Hayashi   +6 more
semanticscholar   +1 more source

Targeting Nupr1‐Mediated p53 Mitochondrial Sequestration Alleviates Aortic Dissection by Restoring the Gadd45b‐Dependent Survival Program

Advanced Science, EarlyView.
This study identifies Nupr1 as a crucial stress‐responsive orchestrator driving AD. Under severe stress, Nupr1 massively accumulates within mitochondria to sequester p53, triggering apoptosis and concurrently repressing the Gadd45b‐mediated survival program.
Xi Yang, Ke‐Yuan Chen, Yue Tian, Zong‐Sheng Jiang, Jian Lei, Xing‐Hui Zhuang, Jiang‐Bin Wu, Le‐Le Tang, Hao‐Yu Li, Xiao‐Hui Chen, Yue Wang, Yu‐Mei Li, Zhi‐Huang Qiu, Zi‐Wen Cai, Liang‐Wan Chen   +14 more
wiley   +1 more source

Fabrication of Microarrays for the Analysis of Serological Antibody Isotypes against Food Antigens

Sensors, 2019
Food intolerance is delayed adverse food reactions which follow consumption of specific foods. The underlying mechanisms are not well understood, but food intolerance is often considered as a type 2 hypersensitivity reaction mediated by immunoglobulin G (
Jeahee Ryu, Soyoun Kim, Jaeseung Song, Daeun Kim, Narae Keum, Wonhee Jang, Hyosang Bae, Youngeun Kwon   +7 more
doaj   +1 more source

Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation

Advanced Science, EarlyView.
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He   +10 more
wiley   +1 more source

Total immunoglobulin (Ig) isotypes concentrations in cervicovaginal lavage (CVL) supernatants of HIV-1 uninfected non-CSW, HESN and HIV-1 infected CSW women.

, 2019
Immunoglobulin (A) M, A, G1 and (B) G2, G3, G4 isotypes concentrations (ng/ml) in CVLs were compared with Mann Whitney U test for pair-wise comparisons between HESNs and the two other groups. Data are presented as mean ± SD. Significance levels are shown
Victoire Perraud (6812498), Catherine Sabourin-Poirier (6812495), Marie-Claude Faucher (2940057), Michel Roger (152025), Michel Alary (180020), Lyvia Fourcade (6812492), Josiane Chagnon-Choquet (594672), Johanne Poudrier (152016), Fernand Guédou (6812501), Annie-Claude Labbé (69266)   +9 more
core   +1 more source

Development of specific immunoglobulin Ga (IgGa) and IgGb antibodies correlates with control of parasitemia in Babesia equi Infection [PDF]

, 2006
In this study, the kinetics of specific immunoglobulin G (IgG) isotypes were characterized in Babesia equi (Theileria equi)-infected horses. IgGa and IgGb developed during acute infection, whereas IgG(T) was detected only after resolution of acute ...
Kappmeyer, Lowell S, Dellagostin, Odir A, Cunha, Cristina W, Knowles, Donald P, Lopez, A Marianela, McGuire, Travis C, Hines, Stephen A   +6 more
core   +1 more source

HECTD1 Directs HIF‐1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis

Advanced Science, EarlyView.
HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu, Qiaoqiao Han, Feixiang Wang, Yuerong Zhang, Haoran Feng, Kun Liu, Fang Xiu Luo, Fei Yuan, Xuesong Zhao, Xiaoyan Yu, Haiyan Huang, Qiang Zou, Ren Zhao   +12 more
wiley   +1 more source

Different genomic organization and expression of immunoglobulin light-chain isotypes in the rainbow trout

, 2000
cDNA studies have distinguished two isotypes of the rainbow trout (Oncorhynchus mykiss) immunoglobulin (Ig) light chain (designated L1 and L2). This study characterized genomic clones of these isotypes.
Partula, S, Timmusk, S,, Pilstrom, L
core