Results 91 to 100 of about 20,447 (254)

DNA (cytosine‐5)‐methyltransferase 3A (Dnmt3a) mutations limit normal and autoreactive CD4+ T follicular helper responses and attenuate T cell‐driven joint inflammation

Arthritis &Rheumatology, Accepted Article.
Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased inflammatory markers. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen, Sanjaykumar Boddul, Zhaojun Li, Zsolt Kasza, Marlene Schülein, Bruno Raposo, Karine Chemin, Per‐Johan Jakobsson, Alexander Espinosa, Lars Klareskog, Fredrik Wermeling   +10 more
wiley   +1 more source

Mutation analysis of IGH associated with different isotypes

, 2014
Immunoglobulin heavy chain rearrangements were sequences from PBMCs of 8 individuals using IGHC primers for all isotypes bar IgE and IgD. Sequencing was carried out on the 454 pyrosequencing platform and rearranged immunoglobulin heavy chain sequences ...
Andrew Collins (543154), Katherine Jackson (511731), Yan Wang (513243)   +2 more
core   +1 more source

[Investigation of immunoglobulin isotypes in patients with fasciolosis].

Mikrobiyoloji bulteni, 2009
The relation between the duration of human fasciolosis and development of humoral immune response has not yet been clarified. This study was conducted to investigate the relation between different immunoglobulin isotypes and the period of disease in fasciolosis patients and also to evaluate the diagnostic value of immunoglobulin isotypes.
Demirci, Mustafa, Tanyel, Tutku Taskinoglu, Kaya, Selcuk   +2 more
openaire   +2 more sources

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Different genomic organization and expression of immunoglobulin light-chain isotypes in the rainbow trout

, 2000
cDNA studies have distinguished two isotypes of the rainbow trout (Oncorhynchus mykiss) immunoglobulin (Ig) light chain (designated L1 and L2). This study characterized genomic clones of these isotypes.
Partula, S, Timmusk, S,, Pilstrom, L
core  

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Tissue transglutaminase immunoglobulin isotypes in children with untreated and treated celiac disease

, 2003
Objectives: Tissue transglutaminase (tTG) autoantibodies are serologic markers for celiac disease (CD). The aim was to determine the diagnostic sensitivity and specificity of different immunoglobulin isotypes against tTG.
Borulf, Stefan, Åke Lernmark, Agardh, Daniel, Daniel Agardh, Sten A. Ivarsson, Lernmark, Åke, Stefan Borulf, Ivarsson, Sten   +7 more
core   +1 more source

Marsupial Ig genomics revisited and the potential role of retroelements in the limited number of heavy chain isotypes

BMC Biology
Background Marsupials have limited germline antibody heavy chain variable (VH) gene diversity and more complex light chain variable gene diversity. They also appear to have a limited repertoire of immunoglobulin heavy chain (IgH) isotypes.
Jordan M. Sampson, Kieran J. Mikolajova, Kourtney M. Zimmerly, Robert D. Miller   +3 more
doaj   +1 more source

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source

Number of mutations found in the classified immunoglobulin IgE and IgG isotype data.

, 2015
For both the isotypes IgE and IgG the total number of mutations and number of unique sequences identified with PaSWAS is given.Number of mutations found in the classified immunoglobulin IgE and IgG isotype data.
Feyruz Yalcin (36058), Jan Peter Nap (57047), Sven Warris (715695), Katherine J. L. Jackson (527252)   +3 more
core   +1 more source