Results 71 to 80 of about 478,815 (317)

Levels of immunoglobulin (Ig) isotypes recognizing HIV-1 envelope proteins gp120 and gp41 in the cervicovaginal lavages (CVLs) of HESN and HIV-1 infected CSW women.

, 2019
Levels of immunoglobulin isotypes recognizing gp120 of HIV-1 (A) IgG1, IgG2 and IgG3, (C) IgA1, IgA2 and IgM, and immunoglobulin isotypes recognizing gp41 of HIV-1 (B) IgG1, IgG2 and IgG3, and (D) IgA1, IgA2 and IgM.
Victoire Perraud (6812498), Catherine Sabourin-Poirier (6812495), Marie-Claude Faucher (2940057), Michel Roger (152025), Michel Alary (180020), Lyvia Fourcade (6812492), Josiane Chagnon-Choquet (594672), Johanne Poudrier (152016), Fernand Guédou (6812501), Annie-Claude Labbé (69266)   +9 more
core   +1 more source

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

Immunoglobulin isotypes in multiple myeloma: laboratory correlates and prognostic implications in total therapy protocols

British Journal of Haematology, 2008
According to Mayo Clinic data concerning the immunoglobulin (Ig) isotype distribution in patients with multiple myeloma (MM), IgG accounts for 52%, IgA for 21% and only light chain secretion for 16%; IgD and IgM phenotypes are rare (2% and 0·5 ...
B. Nair, S. Waheed, J. Szymonifka, J. Shaughnessy, J. Crowley, B. Barlogie   +5 more
semanticscholar   +1 more source

Analysis of antibody isotypes.

, 2016
Anti-Pvs48/45 sera showing positive reactivity to Pfs48/45 in ELISA and Western blotting (4 out of 5 from CFA group and 2 out of 5 from Montanide ISA-51 group) were individually tested to compare immunoglobulin isotypes. ELISA plates coated with Pvs48/45
Yi Cao (229829), Geetha P. Bansal (3149496), Kristen Merino (3149499), Nirbhay Kumar (113311)   +3 more
core   +1 more source

SLC25A4high Hepatocytes Enhance Lifestyle Intervention Response in MASLD by Recruiting Eating Macrophages

Advanced Science, EarlyView.
SLC25A4high hepatocytes drive metabolic‐associated steatotic liver disease (MASLD) remission by recruiting lipid‐eating macrophages. The hepatocyte Slc25a4/PANX1/ATP/P2ry12 axis mediates find‐me signaling that triggers macrophage recruitment and efferocytosis, while recruited macrophages secrete GDF15 to activate hepatocyte PPARα and promote fatty acid
Yiting Qian, Linying Lai, Yu Zhang, Yan Meng, Ziping Song, Baoyuan Huang, Guisheng Song, Bo Sun, Wenzhuo Yang   +8 more
wiley   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Serum immunoglobulins and lymphocyte subset levels and relation to treatment response in children with acute immune thrombocytopenia

Trends in Pediatrics
Objective: In this study, we investigated the initial serum immunoglobulin and lymphocyte subset levels of children with immune thrombocytopenia (ITP), and their association with treatment response.
Mehmet Cemal Dönmez, Mehmet Fatih Orhan, Öner Özdemir, Mustafa Büyükavcı   +3 more
doaj   +1 more source

Number of mutations found in the classified immunoglobulin IgE and IgG isotype data.

, 2015
For both the isotypes IgE and IgG the total number of mutations and number of unique sequences identified with PaSWAS is given.Number of mutations found in the classified immunoglobulin IgE and IgG isotype data.
Feyruz Yalcin (36058), Jan Peter Nap (57047), Sven Warris (715695), Katherine J. L. Jackson (527252)   +3 more
core   +1 more source

Antibody-coated microbiota in nasopharynx of healthy individuals and hypogammaglobulinemia patients.

, 2020
We show that nasopharyngeal microbiota are coated by different immunoglobulin isotypes in healthy individuals and with IgG in X-linked agammaglobulinemia (XLA) patients treated with immunoglobulin replacement ...
Charbit, Bruno, Duffy, Darragh, Di Santo, James, Goncalves, Pedro, Fischer, Alain, Lenoir, Christelle   +5 more
core   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source