Results 1 to 10 of about 49,108 (308)
Interaction of microtubule depolymerizing agent indanocine with different human αβ tubulin isotypes. [PDF]
PLoS ONE, 2018 Tubulin isotypes are known to regulate the stability and dynamics of microtubules, and are also involved in the development of resistance against microtubule-targeted cancer drugs.
Bajarang Vasant Kumbhar +2 more
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Molecules, 2023 Tubulin isotypes are known to regulate microtubule stability and dynamics, as well as to play a role in the development of resistance to microtubule-targeted cancer drugs. Griseofulvin is known to disrupt cell microtubule dynamics and cause cell death in
Parisa Aris +4 more
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Regulation of Tubulin Gene Expression: From Isotype Identity to Functional Specialization
Frontiers in Cell and Developmental Biology, 2022 Genomes of higher eukaryotes encode a large tubulin gene superfamily consisting of at least six α and six β-tubulin isotypes. While some α and β-tubulin isotypes are ubiquitously expressed, others are cell-type specific.
Ivana Gasic
exaly +3 more sources
Antibody dynamics in children with first or repeat Plasmodium falciparum infections
Frontiers in Medicine, 2022 Immunoglobulin (Ig) production during and after infection with Plasmodium parasites is one of the greatest adaptive immune defenses the human host has against this parasite. Infection with P.
Eric Rogier +10 more
doaj +1 more source
The Significance of Anti-Beta-2-Glycoprotein I Antibodies in Antiphospholipid Syndrome
Antibodies, 2016 Antiphospholipid syndrome (APS) is a thrombophilic disorder that classically presents with vascular thrombosis and/or obstetric complications. APS is associated with antiphospholipid antibodies: a heterogeneous group of autoantibodies that are directed ...
Anna Brusch
doaj +1 more source
Clinical & Translational Immunology, 2020 Objectives There is an incomplete understanding of the host humoral immune response to severe acute respiratory syndrome (SARS)‐coronavirus (CoV)‐2, which underlies COVID‐19, during acute infection.
Nancy R Graham +15 more
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Memorias do Instituto Oswaldo Cruz, 2003 In the present report we analyzed the levels of IgG1, IgG2a, IgG2b and IgG3 isotypes from Balb/c mice immunized with cytoplasmic repetitive antigen (CRA), and flagelar repetitive antigen (FRA) of Trypanosoma cruzi.
Valéria RA Pereira +7 more
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Tubulin Isotypes: Emerging Roles in Defining Cancer Stem Cell Niche
Frontiers in Immunology, 2022 Although the role of microtubule dynamics in cancer progression is well-established, the roles of tubulin isotypes, their cargos and their specific function in the induction and sustenance of cancer stem cells (CSCs) were poorly explored.
Tessy Thomas Maliekal +6 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 1996 Immunoglobulin (Ig) isotype (IgG, IgG1, IgG2, IgG3, IgG4, IgM, IgD and IgE) levels were investigated, both pre- and post-treatment with praziquantel (PZQ), in 43 adults and children chronically infected with Schistosoma mansoni , by means of a two-site ...
Romelia M Ramírez +4 more
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Exploring the Origin of Differential Binding Affinities of Human Tubulin Isotypes αβII, αβIII and αβIV for DAMA-Colchicine Using Homology Modelling, Molecular Docking and Molecular Dynamics Simulations. [PDF]
PLoS ONE, 2016 Tubulin isotypes are found to play an important role in regulating microtubule dynamics. The isotype composition is also thought to contribute in the development of drug resistance as tubulin isotypes show differential binding affinities for various anti-
Bajarang Vasant Kumbhar +3 more
doaj +1 more source