Results 1 to 10 of about 50,722 (204)

Tubulin-G protein interaction: The dynamic role of tubulin in the regulation of the neuronal adenylyl cyclase.

, 1990
Tubulin-G protein interaction: The dynamic role of tubulin in the regulation of the neuronal adenylyl ...
Nan. Wang (7984148)
core   +6 more sources

The Game of Tubulins

Cells, 2021
Members of the tubulin superfamily are GTPases; the activities of GTPases are necessary for life. The members of the tubulin superfamily are the constituents of the microtubules and the γ-tubulin meshwork.
Maria Alvarado Kristensson
doaj   +1 more source

Reconstituting Microtubules: A Decades-Long Effort From Building Block Identification to the Generation of Recombinant α/β-Tubulin

Frontiers in Cell and Developmental Biology, 2022
Microtubules are cytoskeletal filaments underlying the morphology and functions of all eukaryotic cells. In higher eukaryotes, the basic building blocks of these non-covalent polymers, ɑ- and β-tubulins, are encoded by expanded tubulin family genes (i.e.,
Shih-Chieh Ti
doaj   +1 more source

SRC Kinase-Mediated Tyrosine Phosphorylation of TUBB3 Regulates Its Stability and Mitotic Spindle Dynamics in Prostate Cancer Cells

Pharmaceutics, 2022
Tubulin is an integral part of the cytoskeleton and plays a pivotal role in cellular signaling, maintenance, and division. β-tubulin is also the molecular target for taxane compounds such as docetaxel (DTX) and cabazitaxel (CTX), both first-line ...
Alan Alfano, Jin Xu, Xi Yang, Dhanraj Deshmukh, Yun Qiu   +4 more
doaj   +1 more source

Design, Synthesis and Cytotoxic Activity Evaluation of Newly Synthesized Amides-Based TMP Moiety as Potential Anticancer Agents over HepG2 Cells

Molecules, 2022
A novel series of amides based TMP moiety was designed, synthesized and evaluated for their antiproliferative as well as enzyme inhibition activity. Compounds 6a and 6b showed remarkable cytotoxic activity against HepG2 cells with IC50 values 0.65 and 0 ...
Tarfah Al-Warhi, Adil Aldhahrani, Fayez Althobaiti, Eman Fayad, Ola A. Abu Ali, Sarah Albogami, Ali H. Abu Almaaty, Amgad I. M. Khedr, Syed Nasir Abbas Bukhari, Islam Zaki   +9 more
doaj   +1 more source

Reformulation of an extant ATPase active site to mimic ancestral GTPase activity reveals a nucleotide base requirement for function

eLife, 2021
Hydrolysis of nucleoside triphosphates releases similar amounts of energy. However, ATP hydrolysis is typically used for energy-intensive reactions, whereas GTP hydrolysis typically functions as a switch.
Taylor B Updegrove, Jailynn Harke, Vivek Anantharaman, Jin Yang, Nikhil Gopalan, Di Wu, Grzegorz Piszczek, David M Stevenson, Daniel Amador-Noguez, Jue D Wang, L Aravind, Kumaran S Ramamurthi   +11 more
doaj   +1 more source

Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds [PDF]

, 2008
Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp.
Henriquez, Fiona L., Rice, David W., Muench, Stephen P., Ingram, Paul R., Roberts, Craig W.   +4 more
core   +4 more sources

Actin and Microtubules Differently Contribute to Vacuolar Targeting Specificity during the Export from the ER

Membranes, 2021
Plants rely on both actin and microtubule cytoskeletons to fine-tune sorting and spatial targeting of membranes during cell growth and stress adaptation.
Monica De Caroli, Fabrizio Barozzi, Luciana Renna, Gabriella Piro, Gian-Pietro Di Sansebastiano   +4 more
doaj   +1 more source

Organization of the Cytoskeleton in Ectopic Foci of the Endometrium with Rare Localization

Biomedicines, 2021
(1) Background: Endometriosis is a common pathology of the female reproductive system, often accompanied by pain and decreased fertility. However, its pathogenesis has not been sufficiently studied regarding the role of the cytoskeleton.
Konstantin A. Toniyan, Victoria V. Povorova, Elena Yu. Gorbacheva, Valery V. Boyarintsev, Irina V. Ogneva   +4 more
doaj   +1 more source

Housekeeping Proteins in Meat Quality Research: Are They Reliable Markers for Internal Controls in Western Blot? A Mini Review

Meat and Muscle Biology, 2022
Advancements in technology and analytical methods enable researchers to explore the biochemical events that cause variation in meat quality. Among those, western blot techniques have been successfully used in identifying and quantifying the key proteins ...
Chaoyu Zhai, Elisabeth J. Huff-Lonergan, Mahesh N. Nair, Steven M. Lonergan   +3 more
doaj   +2 more sources