Results 31 to 40 of about 402,007 (287)
Targeting the Achilles Heel of FtsZ: The Interdomain Cleft
Frontiers in Microbiology, 2021 Widespread antimicrobial resistance among bacterial pathogens is a serious threat to public health. Thus, identification of new targets and development of new antibacterial agents are urgently needed. Although cell division is a major driver of bacterial
Pinkilata Pradhan +3 more
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A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells. [PDF]
, 2014 Dynamic instability, polarity, and spatiotemporal organization are hallmarks of the microtubule cytoskeleton that allow formation of complex structures such as the eukaryotic spindle. No similar structure has been identified in prokaryotes.
Agard, David A +6 more
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NEURONIC SYSTEM INSIDE NEURONS: MOLECULAR BIOLOGY AND BIOPHYSICS OF NEURONAL MICROTUBULES [PDF]
, 2004 Neurons are highly specialized cells that input, process, store and output information. Interneuronal communication is achieved in four basic ways: (i) Ca2+ evoked exocytosis with chemical neurotransmission, (ii) gap junction electrotonic coupling, (iii)
Georgiev, Danko +2 more
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Turgor Pressure and Possible Constriction Mechanisms in Bacterial Division
Frontiers in Microbiology, 2018 Bacterial cytokinesis begins with the assembly of FtsZ into a Z ring at the center of the cell. The Z-ring constriction in Gram-negative bacteria may occur in an environment where the periplasm and the cytoplasm are isoosmotic, but in Gram-positive ...
Masaki Osawa, Harold P. Erickson
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Frontiers in Immunology, 2022 Vaccination is an effective method to prevent Cryptocaryon irritans infection. Although some vaccines have been developed, large-scale production of these vaccines is costly.
Zequan Mo +9 more
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Conformational Dynamics and Thermal Cones of C-terminal Tubulin Tails in Neuronal Microtubules [PDF]
, 2007 In this paper we present a model for estimation of the C-terminal tubulin tail (CTT) dynamics in cytoskeletal microtubules of nerve cells. We show that the screened Coulomb interaction between a target CTT and the negatively charged microtubule surface ...
Georgiev, Danko, Glazebrook, James
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Anticancer Activity of Chamaejasmine: Effect on Tubulin Protein
Molecules, 2011 In this work, the anticancer activity of chamaejasmine was studied by evaluating its in vitro cytotoxicity against several human cancer cell lines (MCF-7, A549, SGC-7901, HCT-8, HO-4980, Hela, HepG2, PC-3, LNCap, Vero and MDCK) using the MTT assay ...
Yingkun Nie, Wenlong Fang, Songtao Liu
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GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease
Cells, 2021 Glycogen synthase kinase 3 (GSK3) was initially isolated as a critical protein in energy metabolism. However, subsequent studies indicate that GSK-3 is a multi-tasking kinase that links numerous signaling pathways in a cell and plays a vital role in the ...
Daria Hajka +5 more
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The Dam1 ring binds to the E-hook of tubulin and diffuses along the microtubule. [PDF]
, 2011 There has been much effort in recent years aimed at understanding the molecular mechanism by which the Dam1 kinetochore complex is able to couple microtubule depolymerization to poleward movement. Both a biased diffusion and a forced walk model have been
Barnes, Georjana +7 more
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Formation and Function of the Rbl2p-beta-Tubulin Complex [PDF]
, 1998 The yeast protein Rbl2p suppresses the deleterious effects of excess beta-tubulin as efficiently as does alpha-tubulin. Both in vivo and in vitro, Rbl2p forms a complex with beta-tubulin that does not contain alpha-tubulin, thus defining a second pool of
Archer, Julie E. +3 more
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