Results 11 to 20 of about 289,598 (269)
γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis.
PLoS ONE, 2012 γ-Tubulin is the key protein for microtubule nucleation. Duplication of the γ-tubulin gene occurred several times during evolution, and in mammals γ-tubulin genes encode proteins which share ∼97% sequence identity.
Stanislav Vinopal +7 more
doaj +1 more source
An essential role for α4A-tubulin in platelet biogenesis
Life Science Alliance, 2019 Alpha4A-tubulin is the predominant α-tubulin isotype in platelets. Mutations in α4A-tubulin cause abnormal platelet biogenesis and marginal band formation in mice and in a patient, establishing an essential role of this tubulin isotype.
Catherine Strassel +22 more
doaj +1 more source
Promiscuous expression of α-tubulin II in maturing male and female Plasmodium falciparum gametocytes. [PDF]
, 2010 BACKGROUND: Antimalarial interventions designed to impact on the transmissible sexual stages of Plasmodium falciparum are evaluated by measurement of peripheral gametocyte carriage in vivo and infectivity to mosquitoes.
Sutherland, Colin J +10 more
core +1 more source
eLife, 2015 Microtubule dynamics and polarity stem from the polymerization of αβ-tubulin heterodimers. Five conserved tubulin cofactors/chaperones and the Arl2 GTPase regulate α- and β-tubulin assembly into heterodimers and maintain the soluble tubulin pool in the ...
Stanley Nithianantham +7 more
doaj +1 more source
Molecules, 2022 A group of novel trimethoxyphenyl (TMP)-based analogues were synthesized by varying the azalactone ring of 2-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxybenzylidene)oxazolone 1 and characterized using NMR spectral data as well as elemental microanalyses ...
Tarfah Al-Warhi +10 more
doaj +1 more source
Pharmaceuticals, 2021 Cancer is a multifaceted disease. With the development of multi drug resistance, the need for the arousal of novel targets in order to avoid these drawbacks increased. A new series of acrylamide derivatives was synthesized from starting material 4-(furan-
Islam Zaki +6 more
doaj +1 more source
Biomolecules, 2023 Tubulin is a protein that plays a critical role in maintaining cellular structure and facilitating cell division. Inhibiting tubulin polymerization has been shown to be an effective strategy for inhibiting the proliferation of cancer cells.
Harutyun Khachatryan +4 more
doaj +1 more source
Recent Advances of Tubulin Inhibitors Targeting the Colchicine Binding Site for Cancer Therapy
Biomolecules, 2022 Cancer accounts for numerous deaths each year, and it is one of the most common causes of death worldwide, despite many breakthroughs in the discovery of novel anticancer candidates.
Mohammed Hawash
doaj +1 more source
Investigation of the marine compound spongistatin 1 links the inhibition of PKCα translocation to nonmitotic effects of tubulin antagonism in angiogenesis [PDF]
, 2009 The aims of the study were to meet the demand of new tubulin antagonists with fewer side effects by characterizing the antiangiogenic properties of the experimental compound spongistatin 1, and to elucidate nonmitotic mechanisms by which tubulin ...
Rothmeier, Andrea S. +7 more
core +1 more source
Pharmaceutics, 2023 LASSBio-1920 was synthesized due to the poor solubility of its natural precursor, combretastatin A4 (CA4). The cytotoxic potential of the compound against human colorectal cancer cells (HCT-116) and non-small cell lung cancer cells (PC-9) was evaluated ...
Celina de Jesus Guimarães +12 more
doaj +1 more source