Results 11 to 20 of about 50,722 (204)
Dose-dependent induction by FQI1 of extra α-tubulin- and γ-tubulin-positive structures.
, 2022 (A) Top: Schematic of treatments of synchronized RPE cells in quiescence by serum starvation. Bottom: Representative images of cells stained for γ-tubulin, α-tubulin and DNA from a total of at least 60 cells over three independent biological experiments ...
Jagesh V. Shah (116400) +12 more
core +1 more source
Evolutionary Divergence of Enzymatic Mechanisms for Tubulin Detyrosination
Cell Reports, 2019 Summary: The two related members of the vasohibin family, VASH1 and VASH2, encode human tubulin detyrosinases. Here we demonstrate that, in contrast to VASH1, which requires binding of small vasohibin binding protein (SVBP), VASH2 has autonomous tubulin ...
Siem van der Laan +13 more
doaj +1 more source
Structural intermediates in the assembly of taxoid-induced microtubules and GDP-tubulin double rings: time-resolved X-ray scattering [PDF]
, 1996 We have studied the self-association reactions of purified GDP-liganded tubulin into double rings and taxoid-induced microtubules, employing synchrotron time-resolved x-ray solution scattering.
Diaz, J.F. +6 more
core +1 more source
γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis.
PLoS ONE, 2012 γ-Tubulin is the key protein for microtubule nucleation. Duplication of the γ-tubulin gene occurred several times during evolution, and in mammals γ-tubulin genes encode proteins which share ∼97% sequence identity.
Stanislav Vinopal +7 more
doaj +1 more source
Promiscuous expression of α-tubulin II in maturing male and female Plasmodium falciparum gametocytes. [PDF]
, 2010 BACKGROUND: Antimalarial interventions designed to impact on the transmissible sexual stages of Plasmodium falciparum are evaluated by measurement of peripheral gametocyte carriage in vivo and infectivity to mosquitoes.
Sutherland, Colin J +10 more
core +2 more sources
An essential role for α4A-tubulin in platelet biogenesis
Life Science Alliance, 2019 Alpha4A-tubulin is the predominant α-tubulin isotype in platelets. Mutations in α4A-tubulin cause abnormal platelet biogenesis and marginal band formation in mice and in a patient, establishing an essential role of this tubulin isotype.
Catherine Strassel +22 more
doaj +1 more source
Molecules, 2022 A group of novel trimethoxyphenyl (TMP)-based analogues were synthesized by varying the azalactone ring of 2-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxybenzylidene)oxazolone 1 and characterized using NMR spectral data as well as elemental microanalyses ...
Tarfah Al-Warhi +10 more
doaj +1 more source
Pharmaceuticals, 2021 Cancer is a multifaceted disease. With the development of multi drug resistance, the need for the arousal of novel targets in order to avoid these drawbacks increased. A new series of acrylamide derivatives was synthesized from starting material 4-(furan-
Islam Zaki +6 more
doaj +1 more source
Biomolecules, 2023 Tubulin is a protein that plays a critical role in maintaining cellular structure and facilitating cell division. Inhibiting tubulin polymerization has been shown to be an effective strategy for inhibiting the proliferation of cancer cells.
Harutyun Khachatryan +4 more
doaj +1 more source
Recent Advances of Tubulin Inhibitors Targeting the Colchicine Binding Site for Cancer Therapy
Biomolecules, 2022 Cancer accounts for numerous deaths each year, and it is one of the most common causes of death worldwide, despite many breakthroughs in the discovery of novel anticancer candidates.
Mohammed Hawash
doaj +1 more source