Results 11 to 20 of about 290,382 (301)
Dose-dependent induction by FQI1 of extra α-tubulin- and γ-tubulin-positive structures. [PDF]
, 2022 (A) Top: Schematic of treatments of synchronized RPE cells in quiescence by serum starvation. Bottom: Representative images of cells stained for γ-tubulin, α-tubulin and DNA from a total of at least 60 cells over three independent biological experiments ...
Jagesh V. Shah (116400) +12 more
core +1 more source
Autopalmitoylation of tubulin [PDF]
Protein Science, 2000 AbstractPure rat brain tubulin is readily palmitoylated in vitro using [3H]palmitoyl CoA but no added enzymes. A maximum of approximately six palmitic acids are added per dimer in 2–3 h at 36–37 °C under native conditions. Both α and β tubulin are labeled, and 63–73% of the label was hydroxylamine‐labile, presumed thioesters.
J, Wolff +3 more
openaire +2 more sources
Cell Cycle, 2007 Microtubules create diverse arrays with specific cellular functions such as the mitotic spindle, cilia and bundles inside neurons. How microtubules are regulated to enable specific functions is not well understood. Recent work has shown that posttranslational modifications of the tubulin building blocks mark subpopulations of microtubules and ...
Kristen J, Verhey, Jacek, Gaertig
openaire +2 more sources
Structural intermediates in the assembly of taxoid-induced microtubules and GDP-tubulin double rings: time-resolved X-ray scattering [PDF]
, 1996 We have studied the self-association reactions of purified GDP-liganded tubulin into double rings and taxoid-induced microtubules, employing synchrotron time-resolved x-ray solution scattering.
Diaz, J.F. +6 more
core +1 more source
γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis.
PLoS ONE, 2012 γ-Tubulin is the key protein for microtubule nucleation. Duplication of the γ-tubulin gene occurred several times during evolution, and in mammals γ-tubulin genes encode proteins which share ∼97% sequence identity.
Stanislav Vinopal +7 more
doaj +1 more source
An essential role for α4A-tubulin in platelet biogenesis
Life Science Alliance, 2019 Alpha4A-tubulin is the predominant α-tubulin isotype in platelets. Mutations in α4A-tubulin cause abnormal platelet biogenesis and marginal band formation in mice and in a patient, establishing an essential role of this tubulin isotype.
Catherine Strassel +22 more
doaj +1 more source
Promiscuous expression of α-tubulin II in maturing male and female Plasmodium falciparum gametocytes. [PDF]
, 2010 BACKGROUND: Antimalarial interventions designed to impact on the transmissible sexual stages of Plasmodium falciparum are evaluated by measurement of peripheral gametocyte carriage in vivo and infectivity to mosquitoes.
Sutherland, Colin J +10 more
core +1 more source
eLife, 2015 Microtubule dynamics and polarity stem from the polymerization of αβ-tubulin heterodimers. Five conserved tubulin cofactors/chaperones and the Arl2 GTPase regulate α- and β-tubulin assembly into heterodimers and maintain the soluble tubulin pool in the ...
Stanley Nithianantham +7 more
doaj +1 more source
Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds [PDF]
, 2008 Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp.
Henriquez, Fiona L. +4 more
core +1 more source
Molecules, 2022 A group of novel trimethoxyphenyl (TMP)-based analogues were synthesized by varying the azalactone ring of 2-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxybenzylidene)oxazolone 1 and characterized using NMR spectral data as well as elemental microanalyses ...
Tarfah Al-Warhi +10 more
doaj +1 more source