Results 21 to 30 of about 402,007 (287)

Design and Synthesis of Newly Synthesized Acrylamide Derivatives as Potential Chemotherapeutic Agents against MCF-7 Breast Cancer Cell Line Lodged on PEGylated Bilosomal Nano-Vesicles for Improving Cytotoxic Activity

Pharmaceuticals, 2021
Cancer is a multifaceted disease. With the development of multi drug resistance, the need for the arousal of novel targets in order to avoid these drawbacks increased. A new series of acrylamide derivatives was synthesized from starting material 4-(furan-
Islam Zaki, Reham A. I. Abou-Elkhair, Ali H. Abu Almaaty, Ola A. Abu Ali, Eman Fayad, Ahmed Gaafar Ahmed Gaafar, Mohamed Y. Zakaria   +6 more
doaj   +1 more source

Surface topography of microtubule walls decorated with monomeric and dimeric kinesin constructs [PDF]

, 2000
The surface topography of opened-up microtubule walls (sheets) decorated with monomeric and dimeric kinesin motor domains was investigated by freeze-drying and unidirectional metal shadowing.
Doerhoefer, Monika, Gross, Heinz, Hoenger, Andreas, Mandelkow, Eckhard, Song, Young Hwa, Tittmann, Peter, Woehlke, Guenther   +6 more
core   +2 more sources

Identification of Inhibitors of Tubulin Polymerization Using a CRISPR-Edited Cell Line with Endogenous Fluorescent Tagging of β-Tubulin and Histone H1

Biomolecules, 2023
Tubulin is a protein that plays a critical role in maintaining cellular structure and facilitating cell division. Inhibiting tubulin polymerization has been shown to be an effective strategy for inhibiting the proliferation of cancer cells.
Harutyun Khachatryan, Bartlomiej Olszowy, Carlos A. Barrero, John Gordon, Oscar Perez-Leal   +4 more
doaj   +1 more source

Recent Advances of Tubulin Inhibitors Targeting the Colchicine Binding Site for Cancer Therapy

Biomolecules, 2022
Cancer accounts for numerous deaths each year, and it is one of the most common causes of death worldwide, despite many breakthroughs in the discovery of novel anticancer candidates.
Mohammed Hawash
doaj   +1 more source

Tubulin bond energies and microtubule biomechanics determined from nanoindentation in silico [PDF]

, 2015
Microtubules, the primary components of the chromosome segregation machinery, are stabilized by longitudinal and lateral non-covalent bonds between the tubulin subunits.
Ataullakhanov, Fazly I., Barsegov, Valeri, Dima, Ruxandra I., Grishchuk, Ekaterina L., Kholodov, Yaroslav, Kononova, Olga, Marx, Kenneth A., Theisen, Kelly E.   +7 more
core   +1 more source

Pharmacokinetic Profile Evaluation of Novel Combretastatin Derivative, LASSBio-1920, as a Promising Colorectal Anticancer Agent

Pharmaceutics, 2023
LASSBio-1920 was synthesized due to the poor solubility of its natural precursor, combretastatin A4 (CA4). The cytotoxic potential of the compound against human colorectal cancer cells (HCT-116) and non-small cell lung cancer cells (PC-9) was evaluated ...
Celina de Jesus Guimarães, Teiliane Rodrigues Carneiro, Marisa Jadna Silva Frederico, Guilherme G. C. de Carvalho, Matthew Little, Valder N. Freire, Victor L. B. França, Daniel Nascimento do Amaral, Jéssica de Siqueira Guedes, Eliezer J. Barreiro, Lídia Moreira Lima, Francisco W. A. Barros-Nepomuceno, Claudia Pessoa   +12 more
doaj   +1 more source

Vimentin Plays a Crucial Role in Fibroblast Ageing by Regulating Biophysical Properties and Cell Migration

Cells, 2019
Ageing is the result of changes in biochemical and biophysical processes at the cellular level that lead to progressive organ decline. Here we focus on the biophysical changes that impair cellular function of human dermal fibroblasts using donors of ...
Kristina Sliogeryte, Núria Gavara
doaj   +1 more source

Design, Synthesis and In Vitro Biological Activity of Novel C-7 Methylene Congeners of Furanoallocolchicinoids

Pharmaceutics, 2023
A series of novel heterocyclic colchicine derivatives bearing a C-7 methylene fragment were synthesized via Wittig, Horner–Wadsworth–Emmons and Nenajdenko–Shastin olefination approaches.
Iuliia A. Gracheva, Elena V. Svirshchevskaya, Ekaterina S. Shchegravina, Yulia B. Malysheva, Alsu R. Sitdikova, Alexey Yu. Fedorov   +5 more
doaj   +1 more source

Structural state recognition facilitates tip tracking of EB1 at growing microtubule ends

eLife, 2019
The microtubule binding protein EB1 specifically targets the growing ends of microtubules in cells, where EB1 facilitates the interactions of cellular proteins with microtubule plus-ends.
Taylor A Reid, Courtney Coombes, Soumya Mukherjee, Rebecca R Goldblum, Kyle White, Sneha Parmar, Mark McClellan, Marija Zanic, Naomi Courtemanche, Melissa K Gardner   +9 more
doaj   +1 more source

Role of Nuclear Lamin A/C in the Regulation of Nav1.5 Channel and Microtubules: Lesson From the Pathogenic Lamin A/C Variant Q517X

Frontiers in Cell and Developmental Biology, 2022
In this work, we studied an lmna nonsense mutation encoding for the C-terminally truncated Lamin A/C (LMNA) variant Q517X, which was described in patients affected by a severe arrhythmogenic cardiomyopathy with history of sudden death. We found that LMNA
Roberta De Zio, Giusy Pietrafesa, Serena Milano, Giuseppe Procino, Manuela Bramerio, Martino Pepe, Cinzia Forleo, Stefano Favale, Maria Svelto, Andrea Gerbino, Monica Carmosino   +10 more
doaj   +1 more source