Results 21 to 30 of about 290,382 (301)
Correlation of serum anti-tubulin-α-1c antibody level and disease activity index in BD patients. [PDF]
, 2018 (a) anti-tubulin-α-1c antibody level positively correlated with ESR; (b) anti-tubulin-α-1c antibody level positively correlated with CRP; (c) anti-tubulin-α-1c antibody level positively correlated with BVAS. BVAS, Birmingham vasculitis activity score.
Cibo Huang (444680) +9 more
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Pharmaceuticals, 2021 Cancer is a multifaceted disease. With the development of multi drug resistance, the need for the arousal of novel targets in order to avoid these drawbacks increased. A new series of acrylamide derivatives was synthesized from starting material 4-(furan-
Islam Zaki +6 more
doaj +1 more source
Tubulin fehérje fragmens és pontmutánsának kölcsönhatása átmenetifém-ionokkal [PDF]
, 2023 Diplomamunkámban a tubulin α doménjének természetes fragmensét (Tub α 1A (195-203)) tanulmányoztam átmenetifém-ionokkal. Ezen fehérjerészlet ciszteint és hisztidint is egyaránt tartalmaz, ezenfelül az -SXC- motívum is fellelhető benne. Célul tűztük ki az
Szondi, Fruzsina Kíra
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Biomolecules, 2023 Tubulin is a protein that plays a critical role in maintaining cellular structure and facilitating cell division. Inhibiting tubulin polymerization has been shown to be an effective strategy for inhibiting the proliferation of cancer cells.
Harutyun Khachatryan +4 more
doaj +1 more source
MOESM5 of A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin [PDF]
, 2019 Additional file 5: Figure S5. Comparison of colchicine binding to γ/γ- and α/β-tubulin dimer. β- and γ-tubulin are shown as ribbon and coloured dark green and cyan, respectively.
Zulema Percario (6574118) +8 more
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Recent Advances of Tubulin Inhibitors Targeting the Colchicine Binding Site for Cancer Therapy
Biomolecules, 2022 Cancer accounts for numerous deaths each year, and it is one of the most common causes of death worldwide, despite many breakthroughs in the discovery of novel anticancer candidates.
Mohammed Hawash
doaj +1 more source
European Journal of Biochemistry, 2000 The 20 cysteine residues of tubulin are heterogeneously distributed throughout its three‐dimensional structure. In the present work, we have used the reactivity of these cysteine residues with 5,5′‐dithiobis(2‐nitrobenzoic acid) (DTNB) as a probe to detect the global conformational changes of tubulin under different experimental conditions.
M, Roychowdhury +7 more
openaire +2 more sources
Investigation of the marine compound spongistatin 1 links the inhibition of PKCα translocation to nonmitotic effects of tubulin antagonism in angiogenesis [PDF]
, 2009 The aims of the study were to meet the demand of new tubulin antagonists with fewer side effects by characterizing the antiangiogenic properties of the experimental compound spongistatin 1, and to elucidate nonmitotic mechanisms by which tubulin ...
Rothmeier, Andrea S. +7 more
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Pharmaceutics, 2023 LASSBio-1920 was synthesized due to the poor solubility of its natural precursor, combretastatin A4 (CA4). The cytotoxic potential of the compound against human colorectal cancer cells (HCT-116) and non-small cell lung cancer cells (PC-9) was evaluated ...
Celina de Jesus Guimarães +12 more
doaj +1 more source
Reduced tubulin tyrosination as an early marker of mercury toxicity in differentiating N2a cells [PDF]
, 2007 The aims of this work were to compare the effects of methyl mercury chloride and Thimerosal on neurite/process outgrowth and microtubule proteins in differentiating mouse N2a neuroblastoma and rat C6 glioma cells.
Lawton, M +4 more
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