Results 51 to 60 of about 50,722 (204)

Tubulin-VDAC Interaction: Molecular Basis for Mitochondrial Dysfunction in Chemotherapy-Induced Peripheral Neuropathy

Frontiers in Physiology, 2019
Tubulin is a well-established target of microtubule-targeting agents (MTAs), a widely used class of chemotherapeutic drugs. Yet, aside from their powerful anti-cancer efficiency, MTAs induce a dose-limiting and debilitating peripheral neurotoxicity ...
Amandine Rovini
doaj   +1 more source

Hierarchical Assembly Pathways of Spermine Induced Tubulin Conical-Spiral Architectures [PDF]

, 2020
Tubulin, an essential cytoskeletal protein, assembles into various morphologies by interacting with cellular factors. Spermine, an endogenous polyamine, promotes and stabilizes tubulin assemblies.
Raviv, Dharan, Israel, Ringel, Uri, Raviv, Yael, Levi-Kalisman, Asaf, Shemesh, Abigail, Millgram   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

SPY Interacts With Tubulin and Regulates Abscisic Acid‐Induced Stomatal Closure in Arabidopsis

Plant Direct
Sugars are important both as an energy source and a signaling cue. In Arabidopsis thaliana, SPINDLY (SPY) is the bona fide O‐fucosylation transferase that links sugar with various plant growth and development processes.
Tongtong Liu, Pan Wang, Zixuan Wang, Weipeng Dun, Jing Li, Rong Yu   +5 more
doaj   +1 more source

Tubulin fehérje fragmens és pontmutánsának kölcsönhatása átmenetifém-ionokkal

, 2023
Diplomamunkámban a tubulin α doménjének természetes fragmensét (Tub α 1A (195-203)) tanulmányoztam átmenetifém-ionokkal. Ezen fehérjerészlet ciszteint és hisztidint is egyaránt tartalmaz, ezenfelül az -SXC- motívum is fellelhető benne. Célul tűztük ki az
Szondi, Fruzsina Kíra
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Template-free 13-protofilament microtubule–MAP assembly visualized at 8 A resolution [PDF]

, 2010
Microtubule-associated proteins (MAPs) are essential for regulating and organizing cellular microtubules (MTs). However, our mechanistic understanding of MAP function is limited by a lack of detailed structural information. Using cryo-electron microscopy
Houdusse, A., Amigues, Beatrice, Clare, Daniel K., Thomas, Geraint, Perderiset, Mylene, Franck J. Fourniol, Fiona Francis, Moores, Carolyn A., Carolyn A. Moores, Daniel K. Clare, Thomas, G., Sindelar, C.V., Fourniol, Franck, Amigues, B., Houdusse, Anne, Franck Fourniol, Charles V. Sindelar, Fourniol, Franck J., Anne Houdusse, Geraint Thomas, Francis, F., Sindelar, Charles V., Francis, Fiona, Perderiset, M., Beatrice Amigues, Mylene Perderiset   +25 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

The novel microtubule-associated CAP-glycine protein Cgp1 governs growth, differentiation, and virulence of Cryptococcus neoformans

Virulence, 2018
Microtubules are involved in mechanical support, cytoplasmic organization, and several cellular processes by interacting with diverse microtubule-associated proteins such as plus-end tracking proteins, motor proteins, and tubulin-folding cofactors.
Li Li Wang, Kyung-Tae Lee, Kwang-Woo Jung, Dong-Gi Lee, Yong-Sun Bahn   +4 more
doaj   +1 more source