Results 71 to 80 of about 50,722 (204)
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Frontiers in Oncology, 2017 The voltage-dependent anion channel (VDAC) is well known as the pathway for passive diffusion of anionic hydrophilic mitochondrial metabolites across the outer membrane, but a more complex functionality of the three isoforms of VDAC has emerged, as ...
John J. Lemasters, John J. Lemasters
doaj +1 more source
, 2019 Additional file 3: Figure S3. Localization of different spindle pole proteins in 3,4,4′-TMS treated cells. HCT116 cells were exposed to 40 μM 3,4,4′-TMS and then immunostained with anti-Aurora A and anti-α-tubulin antibodies, anti-TPX2 and anti-α-tubulin
Zulema Percario (6574118) +8 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini +12 more
wiley +1 more source
Anti-tubulin-α-1cantibody levels in patients and healthy controls.
, 2018 The sensitivity and specificity of tubulin-α-1c antibody in the diagnosis of BD were 61.36% and 88.4% respectively. (BD 44, SLE 51, RAU 32, HC 59, AASV 25, TA 13).
Cibo Huang (444680) +9 more
core +1 more source
A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin [PDF]
, 2019 Background: Resveratrol and its natural stilbene-containing derivatives have been extensively investigated as potential chemotherapeutic agents. The synthetic manipulation of the stilbene scaffold has led to the generation of new analogues with improved
Zulema Percario (6574118) +17 more
core +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Tubulin Role in Cancer Development and Treatment [PDF]
, 2019 This review work is done to show a significance of tubulin in cancer development. Within last decades there are a lot of studies have performed in this area.
Dolhyi, V +3 more
core +2 more sources
Correlation of serum anti-tubulin-α-1cantibodies with clinical features of RA patients.
, 2018 Correlation of serum anti-tubulin-α-1cantibodies with clinical features of RA patients.
Cibo Huang (444680) +9 more
core +1 more source
Engineered Nanotopography to Modulate Growth and Signaling of Neuronal Networks
Advanced Functional Materials, EarlyView.This study examines the interaction between neurons and nanoscale topographies on engineered substrates. Neurons cultured on nanowires, nanopillars and nanoneedles exhibit enhanced neurite outgrowth, form more organized neuronal circuits, and display improved synaptic connectivity, compared to flat substrates.
Hao Nguyen Tran +8 more
wiley +1 more source