Results 71 to 80 of about 290,382 (301)

Resistance to microtubule-stabilising agents following point mutation of human βI-tubulin [PDF]

, 2015
Marine environments represent a rich source of bioactive secondary metabolites that may be harnessed for use in a therapeutic context. Two novel compounds, peloruside A and laulimalide, isolated from the marine sponges Mycale hentsheli and Cacospongia ...
Rowe, Matthew R., Rowe, Matthew R. (11703470)   +1 more
core   +1 more source

Design, synthesis and evaluation of dihydro-1H-indene derivatives as novel tubulin polymerisation inhibitors with anti-angiogenic and antitumor potency

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Angiogenesis plays an important role in tumour generation and progression, which is used to supply nutrients and metastasis. Herein, a series of novel dihydro-1H-indene derivatives were designed and evaluated as tubulin polymerisation inhibitors by ...
Shengtao Xu, Yijun Sun, Peng Wang, Yuchen Tan, Lei Shi, Jian Chen   +5 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Effect of Tubulin Self-Association on GTP Hydrolysis and Nucleotide Exchange Reactions [PDF]

, 2022
Tubulin nucleation, microtubule (MT) assembly, stability, and dynamics depend on GTP hydrolysis and nucleotide exchange reactions. We investigated how the self-association of isolated tubulin dimers affects the rate of GTP hydrolysis and the equilibrium
Raviv, Dharan, Hiba, Ghareeb, Israel, Ringel, Uri, Raviv, Asaf, Shemesh Sadeh, Norman, Metanis   +5 more
core   +1 more source

Tubulin-VDAC Interaction: Molecular Basis for Mitochondrial Dysfunction in Chemotherapy-Induced Peripheral Neuropathy

Frontiers in Physiology, 2019
Tubulin is a well-established target of microtubule-targeting agents (MTAs), a widely used class of chemotherapeutic drugs. Yet, aside from their powerful anti-cancer efficiency, MTAs induce a dose-limiting and debilitating peripheral neurotoxicity ...
Amandine Rovini
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin [PDF]

, 2019
Background: Resveratrol and its natural stilbene-containing derivatives have been extensively investigated as potential chemotherapeutic agents. The synthetic manipulation of the stilbene scaffold has led to the generation of new analogues with improved
Zulema Percario (6574118), Francesca Degrassi (231524), Veronica Morea, Gianandrea Traversi, Zulema Percario, Veronica Morea (1495819), David Sasah Staid, Mario Fiore, Roberto Antonioletti (201575), Renata Cozzi, Daniela Trisciuoglio, Francesca Degrassi, Roberto Antonioletti, Daniela Trisciuoglio (132747), Renata Cozzi (651264), Gianandrea Traversi (6574112), David Staid (6574115), Mario Fiore (231517)   +17 more
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

MAPping out distribution routes for kinesin couriers [PDF]

, 2013
In the crowded environment of eukaryotic cells, diffusion is an inefficient distribution mechanism for cellular components. Long-distance active transport is required and is performed by molecular motors including kinesins.
Moores, Carolyn A., Houdusse, A., Atherton, Joseph, Joseph Atherton, Carolyn Moores, Anne Houdusse   +5 more
core   +1 more source

SPY Interacts With Tubulin and Regulates Abscisic Acid‐Induced Stomatal Closure in Arabidopsis

Plant Direct
Sugars are important both as an energy source and a signaling cue. In Arabidopsis thaliana, SPINDLY (SPY) is the bona fide O‐fucosylation transferase that links sugar with various plant growth and development processes.
Tongtong Liu, Pan Wang, Zixuan Wang, Weipeng Dun, Jing Li, Rong Yu   +5 more
doaj   +1 more source